Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: April 27, 2018

In a state of oxidative stress, there is an increase reactive species, which induce altered intracellular signaling, leading to dysregulation the inflammatory response. The inability antioxidant defense systems modulate proinflammatory response key onset and progression neurodegenerative diseases. aim this work review effect stress on loss regulation microglia astrocytes, induction different CD4+T cell populations in neuroinflammation, as well its role some For purpose, intentional search original articles, short communications, reviews, was carried out following databases: PubMed, Scopus, Google Scholar. articles reviewed included period from 1997 2017. With evidence obtained, we conclude that redox balance induces alterations differentiation number subpopulations, Th1 Th17 This contributes development neuroinflammation diseases such Alzheimer's (AD), Parkinson's (PD), Multiple Sclerosis (MS). contrast, regulatory T cells (Tregs) Th2 cells, microglia, astrocytes. respect, it has been found mobilization with anti-inflammatory characteristics toward damaged regions CNS can provide neuroprotection become therapeutic strategy control processes neurodegeneration.

Language: Английский

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Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders

Oxidative Medicine and Cellular Longevity, Journal Year: 2018, Volume and Issue: 2018(1)

Published: Jan. 1, 2018

A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s Huntington’s and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, inflammation. Intervention strategies using plant‐derived bioactive compounds have been offered a form treatment for these debilitating conditions, there are currently no remedies to prevent, reverse, or halt the progression loss. Rutin, glycoside flavonoid quercetin, is found in many plants fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, oranges. Pharmacological studies reported beneficial effects rutin disease its therapeutic potential several models NDs has created considerable excitement. Here, we summarized current knowledge on neuroprotective various experimental NDs. The action reviewed this article include reduction proinflammatory cytokines, improved antioxidant enzyme activities, activation mitogen‐activated protein kinase cascade, downregulation mRNA expression PD‐linked proapoptotic genes, upregulation ion transport antiapoptotic restoration activities complex enzymes. Taken together, findings suggest that may be promising compound

Language: Английский

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Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

Nutrients, Journal Year: 2019, Volume and Issue: 11(3), P. 648 - 648

Published: March 17, 2019

Glial activation and neuroinflammation play significant roles in apoptosis as well the development of cognitive memory deficits. Neuroinflammation is also a critical feature pathogenesis neurodegenerative disorders such Alzheimer Parkinson's diseases. Previously, hesperetin has been shown to be an effective antioxidant anti-inflammatory agent. In present study, vivo vitro analyses were performed evaluate neuroprotective effects lipopolysaccharide (LPS)-induced neuroinflammation, oxidative stress, neuronal impairments. Based on our findings, LPS treatment resulted microglial astrocytosis elevated expression inflammatory mediators phosphorylated-Nuclear factor-κB (p-NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) cortical hippocampal regions BV2 cells. However, cotreatment markedly reduced cytokines by ameliorating Toll-like receptor-4 (TLR4)-mediated ionized calcium-binding adapter molecule 1/glial fibrillary acidic protein (Iba-1/GFAP) expression. Similarly, attenuated LPS-induced generation reactive oxygen species/lipid per oxidation (ROS/LPO) improved level nuclear factor erythroid 2-related 2 (Nrf2) Haem-oxygenase (HO-1) mouse brain. Additionally, ameliorated cytotoxicity ROS/LPO induced HT-22 Moreover, rescued reducing phosphorylated-c-Jun N-terminal kinases (p-JNK), B-cell lymphoma (Bcl-2)-associated X (Bax), Caspase-3 promoting Bcl-2 level. Furthermore, enhanced synaptic integrity, cognition, processes enhancing phosphorylated-cAMP response element binding (p-CREB), postsynaptic density protein-95 (PSD-95), Syntaxin. Overall, preclinical study suggests that conferred neuroprotection regulating TLR4/NF-κB signaling pathway against detrimental LPS.

Language: Английский

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Role of resveratrol in regulation of cellular defense systems against oxidative stress

BioFactors, Journal Year: 2017, Volume and Issue: 44(1), P. 36 - 49

Published: Nov. 28, 2017

Abstract Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit variety health‐promoting effects including prevention and/or treatment cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, cancer. Cellular defensive properties resveratrol can be explained through its ability either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression cellular genes. As direct antioxidant agent, scavenges diverse ROS/RNS well secondary organic radicals with mechanisms hydrogen atom transfer sequential proton loss electron transfer, thereby protecting biomolecules from oxidative damage. Resveratrol also enhances enzymes heme oxygenase 1, catalase, glutathione peroxidase, superoxide dismutase induction level responsible for maintaining redox balance. Such defenses could achieved by regulating signaling pathways sirtuin nuclear factor‐erythroid 2‐related factor 2 κB. This review provides current understanding information on role defense system against stress. © 2017 BioFactors, 44(1):36–49, 2018

Language: Английский

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Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Cells, Journal Year: 2019, Volume and Issue: 8(8), P. 793 - 793

Published: July 30, 2019

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products detrimental oxidative stress, they have upgraded since, and now ROS are also known to be essential for regulation physiological cellular functions through redox signaling. In majority cases, metabolic demands, along with other stimuli, vital formation their actions. this review, we focus on role in regulating cell functioning communication among themselves. relevance therapy concepts is addressed here.

Language: Английский

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Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: June 9, 2020

Central nervous system (CNS) disorders especially neurodegenerative are the major challenge for public health and demand great attention of researchers to protect people against them. In past few decades, different treatment strategies have been adopted, but their therapeutic efficacy insufficient only shown partial mitigation symptoms further associated with severe adverse effects. Blood-brain barrier (BBB) blood-cerebrospinal fluid (BSCFB) guard CNS from harmful substances pose as challenges in delivering drugs into complications such Alzheimer’s disease, Parkinson’s Huntington’s stroke, epilepsy, brain tumors, multiple sclerosis, encephalitis, many more. Nanotechnology has come out an exciting promising new platform treating neurological potential overcome problems related conventional approaches. Molecules can be nanoengineered carry specific functions cross blood-brain barrier, target cell or signaling pathway, respond endogenous stimuli, act a vehicle gene delivery, support nerve regeneration survival. present review, role nanocarrier systems liposomes, micelles, solid lipid nanoparticles, dendrimers, nanoemulsions delivery various neurotherapeutic agents discussed, besides this, mechanism action, nanoformulation neuroprotective like curcumin, edaravone, growth factors Alzheimer’s, Parkinsonism, stroke tumors reviewed.

Language: Английский

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Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(13), P. 7273 - 7273

Published: June 30, 2022

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of high bioavailability reactive oxygen species (ROS) oxidative stress, chronic/persistent inflammation, glycation, mitochondrial abnormalities. Excessive ROS production results in nucleic acid protein destruction, thereby altering cellular structure functional outcome. To stabilise increased modulate human body produces antioxidants, “free radical scavengers”, that inhibit or delay cell damage. Reinforcing antioxidant defence system and/or counteracting deleterious repercussions immoderate nitrogen (RONS) is critical may curb progression ageing syndromes. Various therapeutic methods for stress reduction have been developed. However, scientific investigations are required to assess their efficacy. In this review, we summarise interconnected mechanism inflammation contributes pathologies, including neurodegenerative diseases, such as Alzheimer’s disease (AD) Parkinson’s (PD), cardiovascular diseases CVD, diabetes mellitus (DM), kidney (CKD). We also highlight potential counteractive measures combat diseases.

Language: Английский

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A review on heme oxygenase-1 induction: is it a necessary evil

Inflammation Research, Journal Year: 2018, Volume and Issue: 67(7), P. 579 - 588

Published: April 24, 2018

Language: Английский

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Bioactivity of Olive Oil Phenols in Neuroprotection

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(11), P. 2230 - 2230

Published: Oct. 25, 2017

Neurological disorders such as stroke, Alzheimer’s and Parkinson’s diseases are associated with high morbidity mortality, few or no effective options available for their treatment. These share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, inflammation apoptosis. A large body evidence supports beneficial effects Mediterranean diet in preventing neurodegeneration. As is characterized by a consumption extra-virgin olive oil it has been hypothesized that oil, particular its phenols, could be responsible effect diet. This review provides an updated vision properties phenols preventing/counteracting both acute chronic neurodegenerative diseases.

Language: Английский

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Antioxidant Functionalized Nanoparticles: A Combat against Oxidative Stress

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(7), P. 1334 - 1334

Published: July 8, 2020

Numerous abiotic stresses trigger the overproduction of reactive oxygen species (ROS) that are highly toxic and reactive. These ROS known to cause damage carbohydrates, DNA, lipids proteins, build oxidative stress results in induction various diseases. To resolve this issue, antioxidants molecules have gained significant attention scavenge these free radicals ROS. However, poor absorption ability, difficulty crossing cell membranes degradation during delivery few challenges associated with both natural synthetic limit their bioavailability. Moreover, use nanoparticles as an antioxidant is overlooked, limited a nanomaterials. address issues, functionalized derived from biological origin emerged important alternative, because properties like biocompatibility, high stability targeted delivery. Algae, bacteria, fungi, lichens plants producers diverse secondary metabolites phenolic compounds extraordinary properties. Hence, could be used amalgamation biogenic (NPs) for better potential. This review intends increase our knowledge about mechanism by which empower combat stress.

Language: Английский

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