Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
64(16), P. 5491 - 5514
Published: Dec. 16, 2022
Neurodegenerative
diseases
are
common
chronic
related
to
progressive
damage
the
nervous
system.
Current
neurodegenerative
present
difficulties
and
despite
extensive
research
efforts
develop
new
disease-modifying
therapies,
there
is
still
no
effective
treatment
for
halting
process.
Polyphenols
biologically
active
organic
compounds
abundantly
found
in
various
plants.
It
has
been
reported
that
plant-derived
dietary
polyphenols
may
improve
some
disease
states
promote
health.
Emerging
pieces
of
evidence
indicate
associated
with
diseases.
This
review
aims
overview
potential
neuroprotective
roles
most
disorders,
including
Alzheimer's
disease,
Parkinson's
epilepsy,
ischemic
stroke.
Journal of Clinical Medicine,
Journal Year:
2020,
Volume and Issue:
9(4), P. 1061 - 1061
Published: April 8, 2020
Among
the
major
neurodegenerative
disorders
(NDDs),
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD),
are
a
huge
socioeconomic
burden.
Over
many
centuries,
people
have
sought
cure
for
NDDs
from
natural
herbals.
Many
medicinal
plants
their
secondary
metabolites
reported
with
ability
to
alleviate
symptoms
of
NDDs.
The
mechanisms
identified,
through
which
phytochemicals
exert
neuroprotective
effects
potential
maintenance
neurological
health
in
ageing,
include
antioxidant,
anti-inflammatory,
antithrombotic,
antiapoptotic,
acetylcholinesterase
monoamine
oxidase
inhibition
neurotrophic
activities.
This
article
reviews
action
some
herbal
products
treatment
according
molecular
targets,
as
well
regional
sources
(Asia,
America
Africa).
A
number
studies
demonstrated
beneficial
properties
plant
extracts
or
bioactive
compounds
against
Herbal
may
potentially
offer
new
options
patients
NDDs,
is
cheaper
culturally
suitable
alternative
conventional
therapies
millions
world
age-related
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
143, P. 112175 - 112175
Published: Sept. 27, 2021
Withania
somnifera
(L.)
Dunal
(Solanaceae)
has
been
used
as
a
traditional
Rasayana
herb
for
long
time.
Traditional
uses
of
this
plant
indicate
its
ameliorative
properties
against
plethora
human
medical
conditions,
viz.
hypertension,
stress,
diabetes,
asthma,
cancer
etc.
This
review
presents
comprehensive
summary
the
geographical
distribution,
use,
phytochemistry,
and
pharmacological
activities
W.
active
constituents.
In
addition,
it
detailed
account
presence
an
constituent
in
many
commercial
preparations
with
curative
health
benefits.
Clinical
studies
toxicological
considerations
extracts
constituents
are
also
elucidated.
Comparative
analysis
relevant
in-vitro,
in-vivo,
clinical
investigations
indicated
potent
bioactivity
phytochemicals
anti-cancer,
anti-inflammatory,
apoptotic,
immunomodulatory,
antimicrobial,
anti-diabetic,
hepatoprotective,
hypoglycaemic,
hypolipidemic,
cardio-protective
spermatogenic
agents.
was
found
to
be
especially
neurological
psychological
conditions
like
Parkinson's
disease,
Alzheimer's
Huntington's
ischemic
stroke,
sleep
deprivation,
amyotrophic
lateral
sclerosis,
attention
deficit
hyperactivity
disorder,
bipolar
anxiety,
depression,
schizophrenia
obsessive-compulsive
disorder.
The
probable
mechanism
action
that
imparts
potential
explored.
However,
in-depth
needed
on
use
diseases.
Besides,
is
performed
safe
efficacious
preclinical
health-promoting
herb.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(2), P. 410 - 410
Published: Jan. 15, 2024
Cannabis,
renowned
for
its
historical
medicinal
use,
harbours
various
bioactive
compounds—cannabinoids,
terpenes,
and
flavonoids.
While
major
cannabinoids
like
delta-9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD)
have
received
extensive
scrutiny
their
pharmacological
properties,
emerging
evidence
underscores
the
collaborative
interactions
among
these
constituents,
suggesting
a
collective
therapeutic
potential.
This
comprehensive
review
explores
intricate
relationships
synergies
between
cannabinoids,
flavonoids
in
cannabis.
Cannabinoids,
pivotal
cannabis’s
bioactivity,
exhibit
well-documented
analgesic,
anti-inflammatory,
neuroprotective
effects.
Terpenes,
aromatic
compounds
imbuing
distinct
flavours,
not
only
contribute
to
sensory
profile
but
also
modulate
cannabinoid
effects
through
diverse
molecular
mechanisms.
Flavonoids,
another
cannabis
component,
demonstrate
antioxidant,
particularly
relevant
neuroinflammation.
The
entourage
hypothesis
posits
that
combined
cannabinoid,
terpene,
flavonoid
action
yields
synergistic
or
additive
effects,
surpassing
individual
compound
efficacy.
Recognizing
nuanced
is
crucial
unravelling
complete
Tailoring
treatments
based
on
holistic
composition
of
strains
allows
optimization
outcomes
while
minimizing
potential
side
imperative
delve
into
roles
flavonoids,
offering
promising
prospects
innovative
interventions
advocating
continued
research
unlock
full
within
realm
natural
plant-based
medicine.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: March 1, 2024
Abstract
Kaempferol,
a
flavonoid
compound
found
in
various
fruits,
vegetables,
and
medicinal
plants,
has
garnered
increasing
attention
due
to
its
potential
neuroprotective
effects
neurological
diseases.
This
research
examines
the
existing
literature
concerning
involvement
of
kaempferol
diseases,
including
stroke,
Parkinson's
disease,
Alzheimer's
neuroblastoma/glioblastoma,
spinal
cord
injury,
neuropathic
pain,
epilepsy.
Numerous
vitro
vivo
investigations
have
illustrated
that
possesses
antioxidant,
anti‐inflammatory,
antiapoptotic
properties,
contributing
effects.
Kaempferol
been
shown
modulate
key
signaling
pathways
involved
neurodegeneration
neuroinflammation,
such
as
PI3K/Akt,
MAPK/ERK,
NF‐κB
pathways.
Moreover,
exhibits
therapeutic
benefits
by
enhancing
neuronal
survival,
attenuating
oxidative
stress,
mitochondrial
calcium
channel
activity,
reducing
promoting
neurogenesis,
improving
cognitive
function.
The
evidence
suggests
holds
promise
natural
for
prevention
treatment
Further
is
warranted
elucidate
underlying
mechanisms
action,
optimize
dosage
regimens,
evaluate
safety
efficacy
this
intervention
human
clinical
trials,
thereby
advancement
scientific
knowledge
field.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2019,
Volume and Issue:
2019, P. 1 - 18
Published: May 16, 2019
Ursolic
acid
(UA)
is
a
pentacyclic
triterpene
which
found
in
common
herbs
and
medicinal
plants
that
are
reputed
for
variety
of
pharmacological
effects.
Both
as
an
active
principle
these
nutraceutical
ingredient,
the
pharmacology
UA
CNS
other
organs
systems
has
been
extensively
reported
recent
years.
In
this
communication,
antioxidant
anti-inflammatory
axis
UA’s
appraised
its
therapeutic
potential
some
disorders.
Classic
examples
include
traumatic
brain
injury
(TBI),
cerebral
ischemia,
cognition
deficit,
anxiety,
depression.
The
efficacy
demonstrated
through
onedrug→multitargets→one/many
disease(s).
specific
enzymes
receptor
targets
along
with
diverse
effects
associated
oxidative
stress
inflammatory
signalling
scrutinised.
Molecules,
Journal Year:
2019,
Volume and Issue:
24(8), P. 1519 - 1519
Published: April 17, 2019
Despite
extensive
progress
in
understanding
the
pathology
of
Alzheimer’s
disease
(AD)
over
last
50
years,
clinical
trials
based
on
amyloid–beta
(Aβ)
hypothesis
have
kept
failing
late
stage
human
trials.
As
a
result,
just
four
old
drugs
limited
outcomes
and
numerous
side
effects
are
currently
used
for
AD
therapy.
This
article
assesses
common
pharmacological
targets
therapeutic
principles
current
future
drugs.
It
also
underlines
merits
natural
products
acting
through
polytherapeutic
approach
monotherapy
option
Multi-targeting
approaches
general
antioxidant
anti-inflammatory
mechanisms
coupled
with
specific
receptor
and/or
enzyme-mediated
neuroprotection,
neuroregeneration,
other
rational
perspectives
novel
drug
discovery
emphasized.
International Journal of Molecular Sciences,
Journal Year:
2018,
Volume and Issue:
19(2), P. 458 - 458
Published: Feb. 3, 2018
Both
caffeic
acid
and
3,4-dihydroxyphenyllactic
(danshensu)
are
synthesized
through
two
distinct
routs
of
the
shikimic
biosynthesis
pathway.
In
many
plants,
especially
rosemary
sage
family
Lamiaceae,
these
compounds
joined
an
ester
linkage
to
form
rosmarinic
(RA).
A
further
structural
diversity
RA
derivatives
in
some
plants
such
as
Salvia
miltiorrhiza
Bunge
is
a
dimer,
salvianolic
acid-B
(SA-B),
that
give
rise
diverse
derivatives.
This
review
provides
comprehensive
perspective
on
chemistry
pharmacology
related
their
potential
therapeutic
applications
dementia.
The
common
causes
dementia,
Alzheimer’s
disease
(AD)
stroke,
employed
scrutinize
effects
vitro
animal
models
Key
pharmacological
mechanisms
beyond
antioxidant
anti-inflammatory
polyphenols
highlighted
with
emphasis
given
amyloid
beta
(Aβ)
pathologies
among
others
neuronal
regeneration
from
stem
cells.
