The combination of artificial intelligence and systems biology for intelligent vaccine design DOI Open Access
Giulia Russo, Pedro A. Reche, Marzio Pennisi

et al.

Expert Opinion on Drug Discovery, Journal Year: 2020, Volume and Issue: 15(11), P. 1267 - 1281

Published: July 14, 2020

A new body of evidence depicts the applications artificial intelligence and systems biology in vaccine design development. The combination both approaches shall revolutionize healthcare, accelerating clinical trial processes reducing costs time involved drug research development.This review explores basics development pipeline. topics include a detailed description epitope prediction tools for designing epitope-based vaccines agent-based models immune system response prediction, along with focus on their potentiality to facilitate phases.Artificial offer opportunity avoid inefficiencies failures that arise classical One promising solution is methodologies multiscale perspective through an accurate We are entering 'in silico era' which scientific partnerships, including more increasing creation 'ecosystem' collaboration multidisciplinary approach, relevant addressing long risky road discovery In this context, regulatory guidance should be developed qualify trials as intelligent

Language: Английский

Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery DOI
Clemente Capasso, Claudiu T. Supuran

Expert Opinion on Therapeutic Patents, Journal Year: 2024, Volume and Issue: 34(6), P. 465 - 474

Published: March 20, 2024

Introduction Carbonic anhydrases (CAs, EC 4.2.1.1) play a pivotal role in the regulation of carbon dioxide , bicarbonate, and hydrogen ions within bacterial cells, ensuring pH homeostasis facilitating energy production. We conducted systematic literature search (PubMed, Web Science, Google Scholar) to examine intricate interplay between CAs metabolism, revealing potential CA inhibitors (CAIs) as innovative therapeutic agents against pathogenic bacteria.

Language: Английский

Citations

17
Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections DOI Creative Commons
Arturo Sánchez, Susana P. Mejía, Jahir Orozco

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(16), P. 3760 - 3760

Published: Aug. 18, 2020

Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative treat intracellular infections. They outstanding performance in delivering antimicrobials intracellularly reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions degradation before reaching the target cell of tissue thus decreasing development resistance microorganisms. The use has potential reduce adverse side effects, providing better efficiency effectiveness regimens, especially drugs having high toxicity, low solubility physiological environment bioavailability. This review provides overview nanoparticles made different polymeric precursors main methodologies nanofabricate platforms tuned physicochemical morphological properties surface chemistry controlled release target. It highlights versatility these nanosystems challenges deliver antimicrobial infections mentions nanotoxicology aspects future outlooks.

Language: Английский

Citations

104
The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases DOI Creative Commons
Xinyu Yang, Di Lu,

Jianyong Zhuo

et al.

International Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 16(13), P. 2357 - 2366

Published: Jan. 1, 2020

The gut microbiota consists of a dynamic multispecies community bacteria, fungi, archaea, and protozoans, playing fundamental role in the induction, training, function host immune system.The liver is anatomically physiologically linked to via enterohepatic circulation, specifically receiving intestine-derived blood through portal vein.The crucial for maintaining homeostasis gut-liver axis.A shift composition can result activation mucosal response causing imbalance.This imbalance results translocation bacteria migration cells liver, which related inflammation-mediated injury tumor progression.In this review, we outline modulating immunity summarize novel findings recent advances immune-based therapeutics associated with axis.Moving forward, deep understanding microbiome-immune-liver axis will provide insight into basic mechanisms dysbiosis affecting diseases.

Language: Английский

Citations

79
T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion DOI Open Access

Freya R Shepherd,

James E. McLaren

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(17), P. 6144 - 6144

Published: Aug. 26, 2020

The human body frequently encounters harmful bacterial pathogens and employs immune defense mechanisms designed to counteract such pathogenic assault. In the adaptive system, major histocompatibility complex (MHC)-restricted αβ T cells, along with unconventional or γδ respond antigens orchestrate persisting protective responses generate immunological memory. Research in past ten years accelerated our knowledge of how cells recognize many species have evolved evade host antimicrobial responses. Such escape act corrupt crosstalk between innate immunity, potentially tipping balance toward pathological rather than protective. This review examines latest developments cell immunity responds evaluates some that bacteria use immunosurveillance, promote virulence survival host.

Language: Английский

Citations

73
Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections DOI
Santhni Subramaniam, Paul Joyce, Nicky Thomas

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 177, P. 113948 - 113948

Published: Aug. 28, 2021

Language: Английский

Citations

70
Essential immune functions of fibroblasts in innate host defense DOI Creative Commons
Kellen Cavagnero, Richard L. Gallo

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 15, 2022

The term fibroblast has been used generally to describe spindle-shaped stromal cells of mesenchymal origin that produce extracellular matrix, establish tissue structure, and form scar. Current evidence found with this morphology are highly heterogeneous some fibroblastic actively participating in both innate adaptive immune defense. Detailed analysis barrier tissues such as skin, gut, lung now show fibroblasts directly sense pathogens other danger signals elicit host defense functions including antimicrobial activity, leukocyte recruitment, production cytokines lipid mediators relevant inflammation immunosuppression. This review will synthesize current literature focused on the performed by at highlight previously unappreciated importance these immunity.

Language: Английский

Citations

43
The Complex Mechanism of the Salmonella typhi Biofilm Formation That Facilitates Pathogenicity: A Review DOI Open Access

Fahmida Jahan,

Suresh V. Chinni, Sumitha Samuggam

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6462 - 6462

Published: June 9, 2022

serovar Typhi (

Language: Английский

Citations

42
Using artificial intelligence technology to fight COVID-19: a review DOI Open Access
Yong Peng, Enbin Liu, Shanbi Peng

et al.

Artificial Intelligence Review, Journal Year: 2022, Volume and Issue: 55(6), P. 4941 - 4977

Published: Jan. 3, 2022

Language: Английский

Citations

39
The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis DOI Creative Commons
Farzaneh Fakharian, Behnoush Asgari, Ali Nabavi-Rad

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Aug. 15, 2022

The human gut microbiota are critical for preserving the health status because they required digestion and nutrient acquisition, development of immune system, energy metabolism. microbial composition is greatly influenced by colonization recalcitrant pathogen Helicobacter pylori ( H. ) conventional antibiotic regimens that follow. considered to be main microorganism in gastric carcinogenesis, it appears early stages process. However, a non- profile also suggested, primarily later tumorigenesis. On other hand, specific groups microbes may produce beneficial byproducts such as short-chain fatty acids (acetate, butyrate, propionate) can modulate inflammation tumorigenesis pathways. In this review, we aim present how influences population modify host immunity trigger carcinogenesis. We will highlight effect on immunotherapeutic approaches checkpoint blockade cancer treatment perspective further innovative therapeutic paradigms prevent progression -induced stomach cancer.

Language: Английский

Citations

38
Intracellular bacteria in cancer—prospects and debates DOI Creative Commons
Lena Schorr, Marius Mathies, Eran Elinav

et al.

npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)

Published: Oct. 9, 2023

Abstract Recent evidence suggests that some human cancers may harbor low-biomass microbial ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in this context, are suggested by these studies to localize within cancer cells, immune cells other tumor microenvironment cell types, where they postulated impact multiple cancer-related functions. Herein, we provide an overview of intratumoral while focusing on intracellular their molecular activities, communication networks, host invasion evasion strategies, long-term colonization capacity. We highlight how integration sequencing-based spatial techniques enable recognition bacterial niches. discuss pitfalls, debates challenges decisively proving existence function microbes, reaching a mechanistic elucidation impacts behavior treatment responses. Together, causative understanding possible roles played bacteria future utilization diagnosis, patient stratification, treatment.

Language: Английский

Citations

38