Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing DOI Open Access
Yu Pan, Nan Hong,

Genwang Wang

et al.

CytoJournal, Journal Year: 2025, Volume and Issue: 22, P. 46 - 46

Published: April 25, 2025

Objective Burns refers to a severe form of trauma that often leads localized and systemic inflammatory responses, oxidative stress, immune dysfunction. Patients with burns are highly susceptible the development postburn sepsis, condition influenced by multiple factors, such as bacterial infection burn wound, alterations in status, excessive release mediators. This study aimed investigate mechanisms which hydrogen gas treatment exerts its effects on focus influence wound healing. Material Methods work employed vitro assays Sprague–Dawley (SD) rat skin fibroblasts (RSFs) assess serum cell proliferation through methylthiazolyldiphenyltetrazolium bromide apoptosis flow cytometry Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, an enzyme-linked immunosorbent assay was performed quantify cytokines stress markers treated serum. Western blotting (WB) analysis conducted signaling pathway modulation. The sepsis models SD rats were segregated into three experimental groups: healthy normal control group, + (2%) group. Wound healing monitored, contraction rates recorded histological assessments using hematoxylin eosin Masson’s trichrome staining evaluate tissue repair collagen deposition. Results showed reduced fibroblast increased ( P < 0.01), mitigated rescuing viability reducing 0.01). Enzyme-linked revealed serum-induced increases levels markers, decreases antioxidant enzymes reversed 0.05). WB suggested gas’s anti-inflammatory proliferative modulating pathways vivo , considerably improved healing, accelerated enhanced Plasma analyses indicated local from gas. Conclusion Hydrogen demonstrates potential therapeutic efficacy management promoting These findings provide scientific evidence supporting adjunctive strategy for sepsis.

Language: Английский

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy DOI Creative Commons
Jiatong Liu, Xiaoyue Han,

Tingyue Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 30, 2023

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses associated with most human diseases. Reactive oxygen species (ROS) are class chemicals that generated after incomplete reduction molecular oxygen. At moderate levels, ROS function as critical signaling molecules in modulation various physiological functions, including responses. However, at excessive exert toxic effects and directly oxidize biological macromolecules, such proteins, nucleic acids lipids, further exacerbating development causing Therefore, designing manufacturing biomaterials scavenge has emerged an important approach for restoring homeostasis, limiting protecting host against damage. This review systematically outlines dynamic balance production clearance under conditions. We focus on mechanisms by which regulate cell proteins how these affect inflammation. Furthermore, we discuss use potential currently available-biomaterials ROS, agents were engineered reduce levels blocking generation, chemically reacting or catalytically accelerating clearance, treatment Finally, evaluate challenges prospects controlled material design scavenging biomaterials.

Language: Английский

Citations

194
Issues and opportunities facing hydrolytic hydrogen production materials DOI
Min Liu, Zhendong Yao, Jing Gu

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 461, P. 141918 - 141918

Published: Feb. 15, 2023

Language: Английский

Citations

106
Combating Oxidative Stress and Inflammation in COVID‐19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives DOI Creative Commons
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four deaths. It caused by an infection the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects alveolar type II pneumocytes. The induces pathological responses including increased inflammation, oxidative stress, apoptosis. This situation results in impaired gas exchange, hypoxia, other sequelae that lead to multisystem organ failure death. As summarized this article, many interventions therapeutics have been proposed investigated combat viral infection-induced inflammation stress contributes etiology pathogenesis of COVID-19. However, these methods not significantly improved treatment outcomes. may partly be attributable their inability at restoring redox inflammatory homeostasis, for molecular hydrogen (H

Language: Английский

Citations

104
Exploring hydrogen energy systems: A comprehensive review of technologies, applications, prevailing trends, and associated challenges DOI
Muhammad Kamran, Marek Turzyński

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 96, P. 112601 - 112601

Published: June 28, 2024

Language: Английский

Citations

42
Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases DOI Open Access

Md. Habibur Rahman,

Johny Bajgai, Ailyn Fadriquela

et al.

Processes, Journal Year: 2021, Volume and Issue: 9(2), P. 308 - 308

Published: Feb. 6, 2021

Oxidative stress (OS) and neuroinflammatory affect many neurological disorders. Despite the clinical significance of oxidative damage in disorders, still, no effective safe treatment methods for neuro diseases are available. With this, molecular hydrogen (H2) has been recently reported as an antioxidant anti-inflammatory agent to treat several stress-related diseases. In animal human trials, routes H2 administration mainly categorized into three types: gas inhalation, water dissolving, H2-dissolved saline injection. This review explores some significant progress research on use neurodegenerative (NDs), including Alzheimer’s disease, Parkinson’s neonatal disorders brain, other NDs (retinal ischemia traumatic brain injury). Even though most problems not currently curable, these studies have shown therapeutic potential prevention, treatment, mitigation administration. Several possible H2-effectors, cell signaling molecules hormones, which prevent OS inflammation, will also be addressed. However, more related required evaluate direct target molecule.

Language: Английский

Citations

46
Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases DOI Creative Commons
Zhiling Fu, Jin Zhang, Yan Zhang

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 17

Published: March 18, 2022

Ageing is a physiological process of progressive decline in the organism function over time. It affects every organ body and significant risk for chronic diseases. Molecular hydrogen has therapeutic preventive effects on various organs. antioxidative properties as it directly neutralizes hydroxyl radicals reduces peroxynitrite level. also activates Nrf2 HO-1, which regulate many antioxidant enzymes proteasomes. Through its effect, maintains genomic stability, mitigates cellular senescence, takes part histone modification, telomere maintenance, proteostasis. In addition, may prevent inflammation nutrient-sensing mTOR system, autophagy, apoptosis, mitochondria, are all factors related to ageing. Hydrogen can be used prevention treatment ageing-related diseases, such neurodegenerative disorders, cardiovascular disease, pulmonary diabetes, cancer. This paper reviews basic research recent application order support use medicine ageing disease therapy.

Language: Английский

Citations

30
Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View DOI Creative Commons
Masaaki Nakayama,

Shigeru Kabayama,

Mariko Miyazaki

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 90 - 90

Published: Jan. 11, 2024

Chronic kidney disease (CKD), which is globally on the rise, has become an urgent challenge from perspective of public health, given its risk factors such as end-stage renal failure, cardiovascular diseases, and infections. The pathophysiology CKD, including dialysis patients, deeply associated with enhanced oxidative stress in both kidneys entire body. Therefore, introduction a safe widely applicable antioxidant therapy expected measure against CKD. Electrolyzed hydrogen water (EHW) generated through electrolysis been confirmed to possess chemical capabilities. In Japan, devices producing this have popular for household drinking water. CKD model experiments conducted date, EHW shown suppress progression damage related hypertension. Furthermore, clinical studies reported that systemic patients undergoing treatment using suppressed, leading reduction incidence complications. future, considering one comprehensive measures holds significant importance. medical utility believed be substantial, further investigation warranted.

Language: Английский

Citations

8
Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders DOI Creative Commons

Lian Wang,

Xin Xie, Bowen Ke

et al.

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 38, P. 261 - 274

Published: Sept. 1, 2021

Endogenous gasotransmitters are small gaseous mediators that can be generated endogenously by mammalian organisms. The dysregulation of the gasotransmitter system is associated with numerous disorders ranging from inflammatory diseases to cancers. However, relevance these endogenous gasotransmitters, prodrug donors and inhibitors in dermatological has not yet been thoroughly reviewed discussed.This review discusses recent progress will provide perspectives on context disorders.Endogenous nitric oxide (NO), carbon monoxide (CO) hydrogen sulfide (H2S) signaling molecules regulate several physiological pathological processes. In addition, sulfur dioxide (SO₂), methane (CH4), gas (H2), ammonia (NH3), (CO2) also may take part These inflammation, vasodilation, oxidative stress, offering therapeutic potential attracting interest field including psoriasis, atopic dermatitis, acne, rosacea, chronic skin ulcers. development effective a promising alternative treat controllable precise delivery future.

Language: Английский

Citations

34
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy DOI Creative Commons
John Sieh Dumbuya,

Siqi Li,

Li‐Li Liang

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 26, 2022

Sepsis-associated encephalopathy (SAE) is one of the most common types sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It associated with higher mortality, low quality life, and long-term neurological sequelae in suspected patients. At present there no specific treatment for SAE rather than supportive therapy judicious use antibiotics, which are sometimes adverse effects. Molecular hydrogen (H2) has been reported to play crucial role regulating inflammatory responses, neuronal injury, apoptosis mitochondrial adult models SAE. Here we report protective effect hydrogen-rich saline juvenile rat model its possible underling mechanism(s).Rats were challenged lipopolysaccharide (LPS) at a dose 8 mg/kg injected intraperitoneally induce sepsis (HRS) administered 1 h following LPS induction 5 ml/kg. Rats divided into: sham, sham + HRS, HRS. 48 h, rats sacrificed Nissl staining TUNEL assay apoptotic cells detection, immunohistochemistry, ELISA protocol cytokines determination, parameters, electron microscopy western blot analysis studied examine HRS LPS-induced septic rats.Rats treated improved improvement rats' survival rate. showed decreased TNF-α IL-1β increased IL-10 expression levels HRS-treated group. Apoptotic after administration rats. The numbers GFAP IBA-1positive attenuated group when compared Subsequently, IBA-1 immunoreactivity treatment. Mitochondrial membrane potential detected by JC-1 dye ATP content rats, treatment, while release ROS was reverted ameliorating dysfunction. Further transmission number mitochondria synapses, disrupted ultrastructure group, synapses number.These data demonstrated that can improve rate, attenuate neuroinflammation, astrocyte microglial activation, injury model, making it therapeutic candidate treating paediatric

Language: Английский

Citations

25
Effects of Coenzyme Q10 on the Biomarkers (Hydrogen, Methane, SCFA and TMA) and Composition of the Gut Microbiome in Rats DOI Creative Commons

Anastasiia Yu. Ivanova,

Ivan V. Shirokov,

Stepan V. Toshchakov

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 686 - 686

Published: May 2, 2023

The predominant route of administration drugs with coenzyme Q10 (CoQ10) is per os. bioavailability CoQ10 about 2-3%. Prolonged use to achieve pharmacological effects contributes the creation elevated concentrations in intestinal lumen. can have an effect on gut microbiota and levels biomarkers it produces. at a dose 30 mg/kg/day was administered os Wistar rats for 21 days. (hydrogen, methane, short-chain fatty acids (SCFA), trimethylamine (TMA)) taxonomic composition were measured twice: before end experiment. Hydrogen methane using fasting lactulose breath test, fecal blood SCFA TMA determined by NMR, 16S sequencing used analyze composition. Administration days resulted 1.83-fold (p = 0.02) increase hydrogen concentration total air sample (exhaled + flatus), 63% (acetate, propionate, butyrate) feces, 126% butyrate 0.04), 6.56-fold 0.03) decrease levels, 2.4-fold relative abundance Ruminococcus Lachnospiraceae AC 2044 group 7.5 times 2.8-fold representation Helicobacter. mechanism antioxidant orally include modification increased generation molecular hydrogen, which itself. evoked level butyric acid be followed protection barrier function.

Language: Английский

Citations

14