Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle

Molecules, Journal Year: 2022, Volume and Issue: 27(8), P. 2494 - 2494

Published: April 12, 2022

Quercetin, an essential plant flavonoid, possesses a variety of pharmacological activities. Extensive literature investigates its antimicrobial activity and possible mechanism action. Quercetin has been shown to inhibit the growth different Gram-positive Gram-negative bacteria as well fungi viruses. The action includes cell membrane damage, change permeability, inhibition synthesis nucleic acids proteins, reduction expression virulence factors, mitochondrial dysfunction, preventing biofilm formation. also various drug-resistant microorganisms, thereby suggesting use potent agent against strains. Furthermore, certain structural modifications quercetin have sometimes enhance compared that parent molecule. In this review, we summarized with special focus on mechanistic principle. Therefore, review will provide further insights into scientific understanding quercetin’s action, implications for clinically relevant agent.

Language: Английский

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Health Benefits of Quercetin in Age-Related Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(8), P. 2498 - 2498

Published: April 13, 2022

Polyphenols are the known group of phytochemicals that essentially consists phenolic rings. These plant product present in varied fruits and vegetables. secondary metabolites perform a protective function plants from environmental biological stress. When consumed as human diet these also to prevent various age-associated diseases. possess antioxidant properties protect against oxidative The literature survey was carried out using databases such PubMed, Science direct Springer. research articles last 10-12 years were selected for this review based on its relevancy with topic. mainly focused quercetin health benefits. highlights main functions flavonoid, quercetin. Quercetin is among widely occurring polyphenol, found abundantly nature. It commonly different products. Onion have highest quantity This compound possessed considered aging. be both free conjugated forms. has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, anti-viral properties. molecule lipophilic can easily cross BBB (Blood-Brain Barrier) hence protects neurodegenerative Various vivo vitro studies demonstrated role here detailed curative agent neurodegeneration, diabetes, cancer, inflammation been out. Studies proved plays crucial prevention age-related disorders. potent which currently being used pharmaceuticals. Properties further explored other Nanoformulations liposomal formulations made treat age associated

Language: Английский

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Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21

Published: Sept. 6, 2022

Plant preparations have been used to treat various diseases and discussed for centuries. Research has advanced discover identify the plant components with beneficial effects reveal their underlying mechanisms. Flavonoids are phytoconstituents anti-inflammatory, antimutagenic, anticarcinogenic, antimicrobial properties. Herein, we listed contextualized aspects of protective flavonols quercetin, isoquercetin, kaempferol, myricetin flavones luteolin, apigenin, 3',4'-dihydroxyflavone, baicalein, scutellarein, lucenin-2, vicenin-2, diosmetin, nobiletin, tangeretin, 5-O-methyl-scutellarein. We presented structural characteristics subclasses, importance, occurrence, food sources. The bioactive compounds present in our diet, such as fruits vegetables, may affect health disease state. Therefore, role these inflammation, oxidative mechanisms, bacterial metabolism; moreover, synergism antibiotics better outcomes. Indiscriminate use allows emergence multidrug-resistant strains; thus, be adjuvant treatment infectious caused by resistant opportunistic bacteria via direct indirect also focused on reported mechanisms intracellular targets flavones, which support therapeutic inflammatory diseases.

Language: Английский

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Potential Implications of Quercetin in Autoimmune Diseases

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 23, 2021

Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and characterized by breakdown dysregulation the immune system. Although their etiology pathogenesis remain unclear, application dietary supplements is gradually increasing in patients autoimmune diseases, mainly due to positive effects, relatively safety, low cost. Quercetin natural flavonoid that widely present fruits, herbs, vegetables. It has been shown have wide range beneficial effects biological activities, including anti-inflammation, anti-oxidation, neuroprotection. In several recent studies quercetin reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus humans or animal models. This review summarizes evidence for pharmacological which supports view may be useful prevention treatment.

Language: Английский

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Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6545 - 6545

Published: Oct. 3, 2022

Quercetin, as a flavonol compound found in plants, has variety of biological activities. It is widely present nature and the human diet, with powerful oxidative properties In this review, antioxidant mechanism broad-spectrum antibacterial quercetin are revealed; intervention effects on pesticide poisoning pathway action investigated; toxic main mycotoxins collection detoxification process summarized; whether it able to reduce toxicity proved; harmful heavy metal collection, prevention, control evaluated. This review expected enrich understanding promote its better application clinical practice.

Language: Английский

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Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113945 - 113945

Published: Oct. 31, 2022

Chronic inflammation plays an imperative role in the onset and progression of chronic diseases including diabetes, hypertension, cancer, allergies, asthma. Diet can modulate different stages since it is a rich source antioxidants bioactive compounds. Flavonoids are compounds abundantly found various food groups such as vegetables, fruits, nuts, cereals, beverages. Recent work on flavonoids has unveiled their potential to regulate or inhibit inflammation. This attributed anti-inflammatory, anti-oxidative, immune-modulatory properties, making invaluable component nutraceutical, pharmaceutical, medicinal applications. However, information related anti-inflammatory mechanism still not well understood. The current review attempt elaborate chemical structure, dietary sources, properties against allergic diseases.

Language: Английский

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Neuropharmacological Effects of Quercetin: A Literature-Based Review

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: June 17, 2021

Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have demonstrated vitro studies, as well vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals also can prevent evolution development of neuronal injury neurodegeneration. The present work aimed to summarize literature about effect using known database sources. Besides, this review focuses on assessment potential utilization complementary or alternative medicine preventing treating neurodegenerative diseases. An up-to-date search was conducted PubMed, Science Direct Google Scholar published dealing with injury, treatment Findings suggest possess neuropharmacological protective brain disorders such Alzheimer’s disease, Amyloid β peptide, Parkinson’s Huntington's multiple sclerosis, amyotrophic lateral sclerosis. In summary, emphasizes advantages being used prevention o different

Language: Английский

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New insights into quercetin nanoformulations for topical delivery

Phytomedicine Plus, Journal Year: 2022, Volume and Issue: 2(2), P. 100257 - 100257

Published: March 14, 2022

Quercetin is one of the most critical endogenous anti-oxidants used widely in cosmetics, nutraceuticals, and pharmaceuticals products for skincare therapeutics due to its protective character against oxidants inflammation. Although low hydrophilicity poor percutaneous absorption quercetin make it an untrustworthy entrant topical delivery, numerous new perspectives have been developed proposed overwhelm these problems. Amongst multiple outlooks, nanoparticles-based drug delivery system has gained highlighted attention showed various advantages delivering a hydrophobic like quercetin. The relevant literature was collected from exhaustive search on databases PubMed, ScienceDirect, Google Scholar, others using keywords, including “quercetin nanoformulations,” “dermal nanoformulations quercetin,” formulations,” many others. Publications English language accessed till July 2021 were chosen, whereas non-English papers, dissertations, unpublished data, non-original papers excluded study. present review comprises last decade Until recently, nanocarriers systems, nanovesicles, nanospheres, nanocapsules, nanogels, nanofibres, nanoemulsions, micelles, gold nanoparticles, silica solid lipid nanoparticles (SLNs), nanostructured carriers (NLCs), skin that not only improves solubility permeability but also augments physicochemical stability provides sustain control release. Nanostructured particles herbal drugs offer several over other conventional systems. Advanced formulations help solving hitches such as solubility, bioavailability quercetin, also, case overcome formidable barrier skin. Indeed, application nanomedicine nano-drug certainly trend. However, clinical utilization formulations, their investigation humans needs be explored. Such exploration along with depth analysis dose optimization can pave way commercial success advanced carrier systems application.

Language: Английский

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Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3813 - 3813

Published: Feb. 14, 2023

It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, have chemical structures, and the most representative flavonoids, phenolic acids, stilbenes. should be noted of closely related to their bioavailability bioaccessibility, as many them rapidly metabolized after administration. Polyphenols—with a protective effect gastrointestinal tract—promote maintenance eubiosis intestinal microbiota against gastric colon cancers. Thus, benefits obtained from dietary supplementation would seem mediated by gut microbiota. Taken at certain concentrations, been shown positively modulate bacterial component, increasing Lactiplantibacillus spp. Bifidobacterium involved in protection barrier decreasing Clostridium Fusobacterium, which negatively associated well-being. Based diet–microbiota–health axis, this review aims describe latest knowledge action health through activity discusses micro-encapsulation strategy improve

Language: Английский

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Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Drug Design Development and Therapy, Journal Year: 2022, Volume and Issue: Volume 16, P. 23 - 66

Published: Jan. 1, 2022

Abstract: The skin is the largest organ in human body, composed of epidermis and dermis. It provides protection acts as a barrier against external menaces like allergens, chemicals, systemic toxicity, infectious organisms. Skin disorders cancer, dermatitis, psoriasis, wounds, aging, acne, infection occur frequently can impact life. According to growing body evidence, several studies have reported that natural products potential for treating disorders. Building on this information, review brief information about action most important vitro vivo research use ten selected inflammatory, neoplastic, their mechanisms been date. related articles were searched from databases, including PubMed, Google, Google Scholar, ScienceDirect. Ten widely reviewed study, with showing anti-inflammatory, antioxidant, anti-microbial, anti-cancer effects main therapeutic actions. Overall, reduce suppress inflammatory markers, tumor necrosis factor-alpha (TNF-α), scavenge reactive oxygen species (ROS), induce cancer cell death through apoptosis, prevent bacteria, fungal, virus infections indicating potentials. This also highlighted challenges opportunities transdermal/topical delivery systems safety considerations Our findings indicated might be low-cost, well-tolerated, safe treatment diseases. However, larger number clinical trials are required validate these findings. Natural combination modern drugs, well development novel mechanisms, represent very promising area future drug discovery leads Keywords: products, disorder,

Language: Английский

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