The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 5152 - 5152

Published: Dec. 3, 2022

Lycopene is a nutraceutical with health-promoting and anti-cancer activities, but due to lack of evidence, there are no recommendations regarding its use dosage. This review aimed evaluate the benefits lycopene supplementation in cancer prevention treatment based on results vivo studies. We identified 72 human animal studies that were then analysed for endpoints such as incidence, improvement outcomes, mechanisms action. concluded most reviewed confirmed activities lycopene. Most concerned prostate cancer, reflecting number vitro The reported action included regulation oxidative inflammatory processes, induction apoptosis, inhibition cell division, angiogenesis, metastasis formation. predominance particular seemed depend tumour organ localisation local storage capacity Finally, need look predictive factors identify population may benefit from supplementation. potential candidates appear be race, single nucleotide polymorphisms carotene-cleaving enzymes, some genetic abbreviations, insulin-like growth factor-dependent diseases.

Language: Английский

---

Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(9), P. 1043 - 1043

Published: Aug. 24, 2022

Owing to the disseminating resistance among pathogenic bacteria, especially Klebsiella pneumoniae, there is a high need for alternate compounds with antibacterial activity. Herein, lycopene was isolated from Lycopersicon esculentum L. Molecular docking approach employed explore binding affinity selected vital proteins of K. pneumoniae mechanisms being investigated. This proposed promising activity lycopene. However, pharmacological use hampered by its poor solubility and limited oral bioavailability. Accordingly, bilosomes were fabricated delivery. The computed entrapment efficiency, mean vesicular size, zeta potential values optimized formulation 93.2 ± 0.6%, 485.8 35.3 nm, -38.3 4, respectively. In vitro drug release studies revealed controlled constructed bilosomes, liberation based on Higuchi kinetics model. Transmission electron microscopic evaluation spherical nanovesicles free aggregates. Moreover, in vivo formulations against multidrug-resistant isolates explored. exhibited lowest minimum inhibitory concentrations ranging 8 32 µg/mL. addition, scanning microscopy remarkable deformation lysis bilosomes-treated bacterial cells. Regarding investigation, lung infection model mice employed. tested reduced inflammation congestion treated mice's tissues, resulting normal-sized bronchioles alveoli very few congested vessels. it resulted significant reduction pulmonary fibrosis. conclusion, this study investigated naturally controlling infections triggered isolates. Furthermore, introduced as biocompatible nanocarrier modulation delivery antimicrobial

Language: Английский

---

Protective effects of lycopene on TiO₂ nanoparticle‐induced damage in the liver of mice

Journal of Applied Toxicology, Journal Year: 2023, Volume and Issue: 43(6), P. 913 - 928

Published: Jan. 12, 2023

Titanium dioxide nanoparticles (nano-TiO2 ) is one of the most widely used and produced nanomaterials. Studies have demonstrated that nano-TiO2 could induce hepatotoxicity through oxidative stress, lycopene has strong antioxidant capacity. The present study aimed to explore if protects liver mice from damage. Ninety-six ICR were randomly divided into eight groups. They control group, -treated group (50 mg/kg BW), lycopene-treated groups (5, 20, 40 50 BW - lycopene-co-treated + 5 lycopene, 20 lycopene). After treated by gavage for 30 days, histopathology was observed. Liver function evaluated using changes in serum biochemical indicators (AST, ALT, ALP); level ROS indirectly reflected SOD, GSH-Px, MDA, GSH, T-AOC. TUNEL assay performed examine apoptosis hepatocytes. Proteins p53, cleaved-caspase 9, 3, Bcl-2, Bax as well p38 detected. Results showed alleviated pathological damage reduced injury induced , decreased -induced ROS. Meanwhile, mitigated resulting accompanied reversed expression apoptosis-related proteins. Furthermore, significantly upregulation p-p38 . In conclusion, this resulted hepatocyte ROS/ROS-p38 MAPK pathway led injury. Lycopene protected against property.

Language: Английский

---

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3821 - 3821

Published: Aug. 31, 2023

Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect lycopene the result its pleiotropic effect. ability to neutralize free radicals via one foundations pro-health effect, including inhibit development many civilization diseases. Therefore, this study focuses on importance in inhibiting diseases such as cardiovascular diseases, within nervous system, diabetes, liver and ulcerative colitis. According research mentioned, supplementation has significant promise for treatment illnesses marked by chronic inflammation oxidative stress. However, majority supporting data lycopene′s health benefits comes from experimental research, whereas evidence clinical studies both scarcer less certain any benefits. Research humans still required establish effectiveness.

Language: Английский

---

The protective effects of flavonoids and carotenoids against diabetic complications—A review of in vivo evidence

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 24, 2023

Diabetes mellitus is a chronic metabolic disorder caused either by inadequate insulin secretion, impaired function, or both. Uncontrolled diabetes characterized hyperglycemia which over time leads to fatal damage both macro-and microvascular systems, causing complications such as cardiovascular diseases, retinopathy and nephropathy. management conventionally delivered through modifications of diet lifestyle pharmacological treatment, using antidiabetic drugs, ultimately injections. However, the side effects financial cost medications often reduce patient compliance negatively affecting their health outcomes. Natural phytochemicals from edible plants fruits vegetables (F&V) medicinal herbs have drawn growing interest potential therapeutic agents for treating preventing onset progression diabetic complications. Flavonoids, most abundant polyphenols in human diet, shown numerous vitro preclinical studies. The underlying mechanisms been linked antioxidant, anti-inflammatory immunomodulatory activities. Carotenoids, another major group dietary phytochemicals, also recent vivo experimental models, possibly mechanism action similar that flavonoids. scientific evidence on efficacy these its clinical settings scarce, delays translation animal study applications limits knowledge modes actions management. This review aimed highlight roles flavonoids carotenoids ameliorating diabetes-related based evidence, i.e., an array studies intervention trials. current general consensus exerted groups key. other are considered. In total, 50 were selected after comprehensive database search via PubMed ScienceDirect January 2002 August 2022. key words used analysis type-2 (T2DM), complications, flavonoids, carotenoids, anti-inflammatory, prevention amelioration, interventions.

Language: Английский

---

Applications and Prospects of CRISPR/Cas9-Mediated Base Editing in Plant Breeding

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(2), P. 918 - 935

Published: Jan. 19, 2023

The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 system (Cas9) has been used at length to optimize multiple aspects of germplasm resources. However, large-scale genomic research indicated that novel variations in crop plants are attributed single-nucleotide polymorphisms (SNPs). Therefore, substituting single bases into a plant genome may produce desirable traits. Gene editing by CRISPR/Cas9 techniques frequently results insertions-deletions (indels). Base allows precise changes the absence double-strand breaks (DSBs) and donor repair templates (DRTs). BEs have provided new way thinking about editing, base currently being utilized edit genomes many different organisms. As traditional breeding modern molecular technologies complement each other, various emerged. How realize greater potential BE applications is question we need consider. Here, explain editings such as CBEs, ABEs, CGBEs. In addition, latest agriculture summarized, including yield, quality, disease, herbicide resistance. Finally, challenges future prospects presented. aim provide comprehensive overview application further improve make most its value.

Language: Английский

---

Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-κB/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 23, 2023

Lycopene (LY) belongs to carotenoids and is abundant in red fruits vegetables. Several previous studies suggested that LY beneficial for ameliorating non-alcoholic fatty liver disease (NAFLD), while the potential mechanisms are unclear. The present study aimed clarify of preventing NAFLD via exploring hepatic NF-κB/NLRP3 inflammasome pathway intestinal microbiota composition high-fat high-fructose diet (HFFD)-fed mice. Fifty eight-week-old male C57BL/6J mice were randomly assigned into 5 groups: Normal control group (NC); HFFD group; with low dose lycopene (LLY, 20 mg/kg/d); high (HLY, 60 mg/kg/d) resveratrol (RSV, 50 mg/kg/d, positive control). After 8 weeks, feces collected 12 h fasted sacrificed acquire tissues blood parameters measurement. results showed LLY, HLY RSV groups had significantly lower body weight gain, white adipose tissue, serum levels density lipoprotein-cholesterol (HDL-C), (LDL-C), lipopolysaccharide (LPS), alanine aminotransferase (ALT), concentrations triglyceride (TG) interleukin-6 (IL-6) than (p < 0.05). also displayed TG, total cholesterol (TC) tumor necrosis factor-α (TNF-α) Liver protein expressions NLRP3, Pro-Caspase-1, Caspase-1 NF-κB those -treated higher relative SCFAs producing bacteria Allobaculum destructive bacteria, including Firmicutes, Lachnospiraceae_NK4A136_group, Desulfovibrio, Alistipes over fecal In conclusion, might prevent by suppressing attenuating gut dysbiosis.

Language: Английский

---

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Language: Английский

---

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 524 - 524

Published: April 10, 2024

The skin is the largest organ of body, and it acts as a protective barrier against external factors. Chronic wounds affect millions people worldwide are associated with significant morbidity reduced quality life. One main factors involved in delayed wound healing oxidative injury, which triggered by overproduction reactive oxygen species. Oxidative stress has been implicated pathogenesis chronic wounds, where known to impair causing damage cellular components, delaying inflammatory phase healing, inhibiting formation new blood vessels. Thereby, treatment requires multidisciplinary approach that addresses underlying causes wound, provides optimal care, promotes healing. Among promising approaches taking care antioxidants gaining interest since they offer multiple benefits related health. Therefore, this review, we will highlight latest advances use natural polymers generate tissue regeneration microenvironments for

Language: Английский

---

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103105 - 103105

Published: March 4, 2024

Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment Alzheimer's disease (AD). These disorders have few treatment options due to side effects limited efficacy. New approaches slow decline are urgently needed. Dietary interventions (nutraceuticals) received considerable attention because they exhibit strong neuroprotective properties may help prevent or minimize AD symptoms. Biological is driven by a series of interrelated mechanisms, including oxidative stress, neuroinflammation, neuronal apoptosis, autophagy, which function through various signaling pathways. Recent clinical preclinical studies shown that dietary small molecules derived from natural sources, flavonoids, carotenoids, polyphenolic acids, modulate damage, impairments, mitochondrial dysfunction, autophagy dysregulation, gut microbiota dysbiosis. This paper reviews research on different their bioactive constituents the AD. Additionally, chemical structure, effective dose, specific molecular mechanisms action comprehensively explored. also discusses advantages using nanotechnology-based drug delivery, significantly enhances oral bioavailability, safety, therapeutic effect, lowers risk adverse effects. agents potential novel safe combat

Language: Английский

---