The Bulletin of Contemporary Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
17(2), P. 79 - 84
Published: April 1, 2024
Introduction.
Systemic
sclerosis
(scleroderma)
is
an
autoimmune
disease
that
often
causes
inflammatory
fibrosing
lesions
of
the
pulmonary
interstitial
tissue,
referred
to
as
lung
disease.
It
associated
with
a
significant
reduction
in
survival
and
leading
immediate
cause
systemic
scleroderma
patients’
death.
Progression
rate
varies
greatly.
Since
specific
immunosuppressive
antifibrotic
treatment
only
justified
case
progressive
lesions,
predicting
progression
great
practical
importance.
Aim:
To
develop
approaches
patients.
Materials
Methods.
Our
analysis
included
data
patients
observed
Registry
Myositis,
Scleroderma
Mixed
Diseases
(REMISSiZ).
Inclusion
criteria:
Age
18+
years,
proven
scleroderma,
eligibility
for
ACR/EULAR
(2013),
repeated
high-resolution
computed
tomography
lungs
interval
at
least
1
year.
All
underwent
6-minute
walking
tests.
Results
Discussion.
The
study
44
(43
women)
aged
62.9
±
11.5
years
average.
average
follow-up
duration
was
530
231
days.
Radiological
younger
age,
p=0.03,
severity
Raynaud’s
phenomenon,
p=0.032,
shorter
duration,
p=0.038,
distance
covered
walk
test,
p=0.05.
functional
impairment,
determined
by
dynamics
decrease
blood
oxygen
saturation
rest
(p=0.003),
breath
shortness
according
Borg
scale
(p=0.006),
initial
test
(p
<0.001),
presence
topoisomerase
I
antibodies
(anti-Scl-70,
p=0.034),
complaints
(p=0.043)
dysphagia
(p=0.034).
As
result
reverse
stepwise
selection
variables,
three
independent
predictors
were
selected
from
above
indicators:
Dysphagia,
anti-Scl-70,
test.
Based
on
these
indicators,
regression
formula
presented
impairment
Conclusions.
X-ray-detected
age
phenomenon
severity.
predict
decline
functionality,
it
advisable
consider
(anti-Scl-70).
The Bulletin of Contemporary Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
17(2), P. 91 - 97
Published: April 1, 2024
Introduction.
HIV
infection,
despite
the
measures
taken,
continues
to
spread
throughout
world.
Unfavorable
course
of
diseases
is
often
determined
by
some
concomitant
pathologies.
Among
HIV-infected
patients,
tuberculosis
most
common
disease
forming
comorbid
condition
named
“TB/HIV”
that
reaches
more
than
a
half
all
cases
newly
diagnosed
in
regions
Russia.
In
recent
years,
due
increase
HIV-
infected
patients’
life
expectancy
based
on
antiretroviral
therapy,
cardiovascular
diseases,
such
as
primarily
infectious
pericarditis,
are
gradually
beginning
hold
significant
place.
Aim:
To
select
and
analyze
publications
dealing
with
tuberculosis-associated
pericarditis.
Materials
Methods.
A
systematic
search
was
conducted
for
examined
possible
associations
between
pericardial
damage,
infection
tuberculosis.
carried
out
electronic
databases
PubMed,
www.pubmed.gov;
MEDLINE,
www.ncbi.
nlm.nih.gov;
Russian
scientific
database
eLibrary,
https://www.elibrary.ru.
Preference
given
meta-analyses
or
reviews,
studies
duplicate
materials
were
excluded
from
analysis.
Results
Discussion.
Publications
epidemiology
pericarditis
associated
world
Russia
presented
authors
different
countries;
both
human
immunodeficiency
virus
mycobacterium
important
development
Tuberculous
being
rare
manifestation
tuberculosis,
usually
reflects
severity
an
unfavorable
prognosis.
unexplained
effusion,
it
advisable
include
testing
differential
diagnosis
plan.
Conclusions.
Diagnosis
requires
multidisciplinary
approach;
late
has
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
152, P. 113199 - 113199
Published: May 30, 2022
Sepsis-induced
cardiac
dysfunction
is
a
leading
cause
of
mortality
in
intensive
care
units.
However,
the
molecular
mechanisms
underlying
septic
cardiomyopathy
remain
elusive.
Irisin
cleaved
product
fibronectin
type
III
domain-containing
protein
5
(FNDC5)
that
protects
heart
from
ischemia/reperfusion
injury
through
upregulation
mitochondrial
ubiquitin
ligase
(MITOL).
Gasdermin
D
(GSDMD)-dependent
pyroptosis
plays
pivotal
role
by
regulating
homeostasis.
whether
irisin
can
regulate
MITOL
to
inhibit
GSDMD-dependent
yet
be
investigated.
Thus,
this
study
was
designed
explore
and
its
mechanisms.
Our
results
demonstrate
improves
function
against
sepsis-induced
reducing
inflammation
myocardial
pyroptosis.
Using
siRNA
vitro,
revealed
protective
lipopolysaccharide
(LPS)-induced
cell
mediated
activation
resulting
inhibition
Moreover,
alleviated
LPS-induced
H9c2
suppressing
IL-1β
expression
serum
LDH
CK-MB
concentrations
MITOL/GSDMD-dependent
manner.
Collectively,
our
data
suggest
treatment
ameliorates
activating
inhibiting
These
findings
highlight
clinical
relevance
therapeutic
potential
for
management
dysfunction.
Foods,
Journal Year:
2022,
Volume and Issue:
11(16), P. 2439 - 2439
Published: Aug. 13, 2022
Accumulating
evidence
shows
that
oxidative
stress
and
inflammation
contribute
to
the
development
of
cardiovascular
disease.
It
has
been
suggested
propolis
possesses
antioxidant
anti-inflammatory
activities.
In
this
study,
effects
main
flavonoids
(chrysin,
pinocembrin,
galangin,
pinobanksin)
extract
were
researched.
The
results
showed
cellular
ROS
(Reactive
oxygen
species)
levels,
enzymes,
Nrf2
(Nuclear
factor
erythroid
2-related
2)
nuclear
translocation,
expression
NQO1
(NAD(P)H:quinone
oxidoreductase
1)
HO-1
(heme
oxygenase
regulated
by
different
concentrations
individual
extract,
which
good
pro-oxidant
effects.
For
example,
levels
decreased;
SOD
CAT
activities
increased;
protein
was
increased
chrysin.
demonstrated
NO
(Nitric
Oxide),
NOS
Oxide
Synthase),
activation
NF-κB
signaling
pathway
inhibited
in
a
dose-dependent
manner
extract.
Moreover,
revealed
phytochemicals
presented
at
lower
but
stronger
higher
concentrations.
To
maintain
balance
effects,
it
is
possible
activate
kappa
B)
pathway.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116007 - 116007
Published: Jan. 3, 2024
Diabetic
cardiomyopathy
(DCM)
is
a
common
complication
of
diabetes
mellitus
(DM).
However,
the
mechanisms
underlying
DCM-induced
cardiac
injury
remain
unclear.
Recently,
role
cyclic
GMP-AMP
synthase/stimulator
interferon
gene
(cGAS/STING)
signaling
and
pyroptosis
in
DCM
has
been
investigated.
Based
on
our
previous
results,
this
study
was
designed
to
examine
impact
irisin,
mitochondrial
ubiquitin
ligase
(MITOL/MARCH5),
cGAS/STING
dysfunction
effect
gasdermin
D
(GSDMD)-dependent
pyroptosis.
High-fat
diet-induced
mice
H9c2
cells
were
used
for
geometry
function
or
pyroptosis-related
biomarker
assessment
at
end
experiments.
Here,
we
show
that
impairs
by
increasing
fibrosis
GSDMD-dependent
pyroptosis,
including
activation
MITOL
signaling.
Our
results
confirmed
protective
irisin
partially
offset
We
also
demonstrated
plays
pivotal
pathological
process
pathogenesis.
indicate
treatment
protects
against
injury,
homeostasis,
through
upregulation.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Dec. 16, 2021
Mitochondrial
autophagy
(or
mitophagy)
regulates
the
mitochondrial
network
and
function
to
contribute
multiple
cellular
processes.
The
protective
effect
of
homeostatic
mitophagy
in
cardiovascular
diseases
(CVDs)
has
attracted
increasing
attention.
FUN14
domain
containing
1
(FUNDC1),
an
identified
receptor,
plays
essential
role
CVDs.
Different
expression
levels
FUNDC1
its
phosphorylated
state
at
different
sites
alleviate
or
exacerbate
hypoxia
ischemia/reperfusion
injury,
cardiac
hypertrophy,
metabolic
damage
through
promotion
inhibition
mitophagy.
In
addition,
can
be
enriched
contact
between
mitochondria
endoplasmic
reticulum
(ER),
determining
formation
mitochondria-associated
membranes
(MAMs)
that
regulate
calcium
(Ca2+)
homeostasis
dynamics
prevent
heart
dysfunction.
Moreover,
also
been
involved
inflammatory
such
as
septic
cardiomyopathy.
this
review,
we
collect
summarize
evidence
on
roles
exclusively
various
CVDs,
describing
interactions
with
organelles,
involvement
processes,
associated
signaling
pathways.
may
become
a
promising
therapeutic
target
for
prevention
management
