Detoxification of Selenium Yeast on Mycotoxins and Heavy Metals: a Review

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 201(11), P. 5441 - 5454

Published: Jan. 20, 2023

Language: Английский

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Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1500 - 1500

Published: May 22, 2023

Mitochondria are the main site of intracellular synthesis ATP, which provides energy for various physiological activities cell. Cardiomyocytes have a high density mitochondria and mitochondrial damage is present in variety cardiovascular diseases. In this paper, we describe cardiomyopathy, congenital heart disease, coronary myocardial ischemia-reperfusion injury, failure, drug-induced cardiotoxicity, context key roles cardiac development homeostasis. Finally, discuss current therapeutic strategies aimed at alleviating impairment-related dysfunction, including pharmacological strategies, gene therapy, replacement transplantation. It hoped that will provide new ideas treatment

Language: Английский

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Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1712 - 1712

Published: Sept. 2, 2023

Gastric cancer (GC) is the fifth most common worldwide and makes up a significant component of global burden. Helicobacter pylori (H. pylori) influential risk factor for GC, with International Agency Research on Cancer classifying it as Class I carcinogen GC. H. has been shown to persist in stomach acid decades, causing damage stomach’s mucosal lining, altering gastric hormone release patterns, potentially function. Epidemiological studies have that eliminating reduces metachronous cancer. Evidence shows various molecular alterations are present precancerous lesions associated an infection. However, although can cause oxidative stress-induced cancer, antioxidants being treatment exact mechanism underlying GC etiology not fully understood. This review provides overview recent research exploring pathophysiology pylori-induced stress antioxidant supplements reduce or even eliminate occurrence.

Language: Английский

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The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 193 - 193

Published: Dec. 22, 2023

Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the one-carbon cycle. This essential for metabolism of methionine, folate, and RNA, as well production proteins, DNA, RNA. MTHFR catalyses irreversible conversion 5,10-methylenetetrahydrofolate to its active form, 5-methyltetrahydrofolate, co-substrate homocysteine remethylation methionine. Numerous variants gene have been recognised, among which C677T variant most extensively studied. The polymorphism, results valine alanine at codon 222, associated with reduced activity an increased thermolability enzyme. Impaired efficiency levels homocysteine, can contribute reactive oxygen species development oxidative stress. Homocysteine acknowledged independent risk factor cardiovascular disease, while chronic inflammation serves common underlying these issues. Many studies conducted determine whether there association between polymorphism hypertension, diabetes, overweight/obesity. There substantial evidence supporting this association, although several concluded that cannot be reliably used prediction. review examines latest research on polymorphisms their correlation obesity, epigenetic regulation.

Language: Английский

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Current state of knowledge of triclosan (TCS)-dependent reactive oxygen species (ROS) production

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118532 - 118532

Published: Feb. 22, 2024

Language: Английский

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