Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(5), P. 593 - 608

Published: Feb. 8, 2023

Centella asiatica is an ethnomedicinal herbaceous species that grows abundantly in tropical and sub-tropical regions of China, India, South-Eastern Asia Africa. It a popular nutraceutical employed various forms clinical cosmetic treatments. C. extracts are reported widely Ayurvedic Chinese traditional medicine to boost memory, prevent cognitive deficits improve brain functions. The major bioactive constituents the pentacyclic triterpenoid glycosides, asiaticoside madecassoside, their corresponding aglycones, asiatic acid madecassic acid. Asiaticoside madecassoside have been identified as marker compounds Pharmacopoeia these triterpene offer wide range pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti-inflammatory, anti-oxidant, anti-allergic, anti-depressant, anxiolytic, antifibrotic, antibacterial, anti-arthritic, anti-tumour immunomodulatory activities. also used extensively treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis scleroderma. Besides medicinal applications, phytocompounds considered cosmetically beneficial for role anti-ageing, hydration, collagen synthesis, UV protection curing scars. Existing reports experimental studies on between 2005 2022 selectively reviewed this article provide comprehensive overview numerous therapeutic advantages potential roles medical future.

Language: Английский

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Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1381 - 1399

Published: Jan. 12, 2024

Abstract Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several attempts have been made identify new potential chemicals combat these neurological abnormalities. At present, complete abolishment diseases is not attainable except for symptomatic relief. However, dietary recommendations help brain development or improvement increased over years. In recent times, cruciferous vegetables their phytochemicals identified from preclinical clinical investigations as neuroprotective The present review highlights beneficial effects molecular mechanisms such indole‐3‐carbinol, diindolylmethane, sulforaphane, kaempferol, selenium, lutein, zeaxanthin, vitamins against including Parkinson's disease, Alzheimer's stroke, Huntington's autism spectra disorders, anxiety, depression, pain. Most protect by eliciting antioxidant, anti‐inflammatory, antiapoptotic properties. Regular intake may benefit prevention treatment diseases. suggests that there a lacuna in identifying efficacy phytochemicals. Therefore, high‐quality future studies should firmly establish above‐mentioned settings.

Language: Английский

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Glucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 912 - 912

Published: March 7, 2025

Glucosinolates (GSLs) are sulfur-containing compounds predominantly found in cruciferous vegetables such as broccoli, kale, and Brussels sprouts, recognized for their health-promoting properties. Upon consumption, GSLs undergo hydrolysis by the enzyme myrosinase, resulting bioactive like isothiocyanates specific indole glucosinolate degradation products, indole-3-carbinol (I3C) 3,3′-diindolylmethane (DIM), which contribute to a range of health benefits, including anti-cancer, anti-inflammatory, cardioprotective effects. This review explores structure, metabolism, bioavailability GSLs. Recent evidence supports protective role chronic diseases, with mechanisms modulation oxidative stress, inflammation, detoxification pathways. Furthermore, innovative strategies enhance GSL bioactivity, biofortification, genetic introgression, optimized food processing methods, have been examined. These approaches seek increase content edible plants, thereby maximizing benefits. comprehensive provides insights into dietary recommendations, impact preparation, recent advances enhancement, highlighting significant potential these promoting human preventing diseases.

Language: Английский

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ß-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance

Phytomedicine, Journal Year: 2022, Volume and Issue: 108, P. 154502 - 154502

Published: Oct. 13, 2022

Language: Английский

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Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida spp.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1531 - 1531

Published: Oct. 30, 2023

Bacterial and fungal biofilm has increased antibiotic resistance plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat reduce the efficacy of medical devices. This global problem prompted extensive research find alternative strategies fight microbial infections. Plant bioactive metabolites with antibiofilm activity known be potential resources alleviate this problem. The phytochemical screening some medicinal plants showed different active groups, such as stilbenes, tannins, alkaloids, terpenes, polyphenolics, flavonoids, lignans, quinones, coumarins. Synergistic effects can observed interaction between plant compounds conventional drugs. review analyses summarises current knowledge on synergistic combination antimicrobials against biofilms Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans. synergism modify inhibit mechanisms acquired resistance, undesirable effects, obtain appropriate therapeutic effect at lower doses. A deeper these combinations their possible targets is needed develop next-generation novel and/or improve drug-resistant attributed biofilm.

Language: Английский

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The Valorization of Wastes and Byproducts from Cruciferous Vegetables: A Review on the Potential Utilization of Cabbage, Cauliflower, and Broccoli Byproducts

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1163 - 1163

Published: April 11, 2024

The management of vegetable waste and byproducts is a global challenge in the agricultural industry. As commonly consumed crop, cruciferous vegetables marked higher amounts wastage during their supply chain processes, with significant contribution from cabbage, cauliflower, broccoli. Therefore, sustainable resource-efficient utilization discarded materials crucial. This review explores potential applications byproducts, spotlighting broccoli food, medicinal, other industries. Their significance being utilized value-added addressed, emphasizing important biomolecules, technologies involved valorization process, future aspects practical applications. Cabbage, generate low-processing including leaves, stems, stalks, rot. Most them contain high-value bioactive proteins phytochemicals, glucosinolates, flavonoids, anthocyanins, carotenoids, tocopherols. Interestingly, isothiocyanates, derived exhibit strong anti-inflammatory anticancer activity through various interactions cellular molecules modulation key signaling pathways cells. these cruciferous-based residues can be valorized efficiently innovative extraction biotransformation techniques, as well employing different biorefinery approaches. not only minimizes environmental impact but also contributes to development high-value-added products for related

Language: Английский

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Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity

Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2295 - 2295

Published: Aug. 18, 2024

In recent years, the supercritical CO

Language: Английский

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Health Benefits of Kimchi, Sauerkraut, and Other Fermented Foods of the Genus Brassica

Applied Microbiology, Journal Year: 2024, Volume and Issue: 4(3), P. 1165 - 1176

Published: July 28, 2024

Fermented foods made through microbial growth and enzymatic conversions have been integral to human diets for at least 10,000 years. Recent interest in fermented has surged due their functional properties health benefits. Cruciferous vegetables of the genus Brassica, such as cabbage, broccoli, cauliflower, are commonly used produce like sauerkraut, kimchi, pao cai, turnips, others. These rich lactic acid bacteria (LAB) bioactive compounds, which contribute potential health-promoting properties. We examined 12 clinical trials investigating Brassica. studies, mainly assessed benefits kimchi or sauerkraut consumption, found that regular intake can alleviate symptoms irritable bowel syndrome (IBS), aid weight loss, enhance metabolic health. Seven observational studies also observed when consuming Six seven on linked reduced obesity risk other An study cabbage consumption breast cancer risk. Despite these findings, exact roles various microorganisms compounds within effects require further investigation. This review underscores cruciferous foods, advocates more mechanistic understand optimize

Language: Английский

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Health Benefits, Applications, and Analytical Methods of Freshly Produced Allyl Isothiocyanate

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 579 - 579

Published: Feb. 10, 2025

Allyl isothiocyanate (AITC) is a low-molecular-weight natural chemical predominantly obtained from the autolysis of sinigrin, glucosinolate found in cruciferous vegetables like mustard, horseradish, and wasabi. AITC has sparked widespread interest due to its various biological actions, which include strong antioxidant, anti-inflammatory, antibacterial, anticancer capabilities. This compound offers promising potential several fields, particularly food preservation, medicine, enhancing quality through means. AITC's effectiveness against broad spectrum microorganisms, including foodborne pathogens spoilage agents, makes it an attractive alternative synthetic preservatives. The extend shelf life perishable foods important tool for production, meeting rising customer demand additives. In addition antimicrobial effects, demonstrates significant anti-inflammatory activity, reducing levels pro-inflammatory cytokines modulating key signaling pathways, could make valuable managing chronic inflammatory conditions. Furthermore, emerging research highlights cancer prevention treatment, as been demonstrated induce apoptosis inhibit cell increase lines, offering approach chemoprevention. review delves into structure, metabolism, bioavailability freshly produced AITC, providing comprehensive overview beneficial properties. Challenges related volatility, dosage optimization, regulatory considerations are also discussed, alongside future directions enhance stability efficacy AITC-based formulations. findings underscore role versatile bioactive with known support human health sustainable industry.

Language: Английский

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Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Indole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism treat obesity in mice. The experimental analyses focused on changes lipid distribution, inflammatory cytokines, glucose tolerance, microbiota composition, serum metabolomics of 60 C57BL/6N results demonstrated that reduced body weight, hepatic steatosis, systemic inflammation improved insulin resistance mice high-fat diet (HFD). Furthermore, remarkably enhanced enrichment probiotics Akkermansia Ligilactobacillus as well SCFA-producing bacteria (Eubacterium, Lactococcus, Coprococcus), while reducing abundance Eisenbergiella Rikenellaceae_RC9_gut_group. Also, notably up-regulated levels Claudin4, Occludin, ZO-1 proteins modulated argininosuccinic acid galactose. aforementioned findings suggest exerts significant anti-obesity effect by regulating abnormal microbiome, enhancing improving metabolic disorders.

Language: Английский

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