Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106366 - 106366
Published: Nov. 1, 2024
Language: Английский
Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 746 - 746
Published: Aug. 9, 2024
Antibiotic resistance emerged shortly after the discovery of first antibiotic and has remained a critical public health issue ever since. Managing in clinical settings continues to be challenging, particularly with rise superbugs, or bacteria resistant multiple antibiotics, known as multidrug-resistant (MDR) bacteria. This rapid development compelled researchers continuously seek new antimicrobial agents curb resistance, despite shrinking pipeline drugs. Recently, focus shifted plants, fungi, lichens, endophytes, various marine sources, such seaweeds, corals, other microorganisms, due their promising properties. For this review, an extensive search was conducted across scientific databases, including PubMed, Elsevier, ResearchGate, Scopus, Google Scholar, encompassing publications from 1929 2024. review provides concise overview mechanisms employed by develop followed in-depth exploration plant secondary metabolites potential solution MDR pathogens. In recent years, interest plant-based medicines surged, driven advantageous However, additional research is essential fully understand action verify safety phytochemicals. Future prospects for enhancing use combating antibiotic-resistant pathogens will also discussed.
Language: Английский
Citations
29
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 7, 2025
Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2455 - 2455
Published: March 10, 2025
The increasing emergence and dissemination of multidrug-resistant (MDR) bacterial pathogens have intensified the need for new antibiotics alternative therapeutic strategies. Flavonoids, a diverse group bioactive natural compounds found in plants, shown significant promise as antibacterial agents. Flavonoids inhibit growth through various mechanisms, including disruption cell wall synthesis, prevention biofilm formation, membrane integrity, inhibition efflux pumps. These actions not only reduce viability but also enhance efficacy conventional antibiotics, offering potential solution to antibiotic resistance. However, challenges such poor bioavailability limit their clinical application. Recent advances nanotechnology-based drug delivery systems, chemical modifications, formulation techniques improving flavonoid efficacy. This review evaluates mechanisms flavonoids, explores synergistic effects with highlights strategies overcome issues. Our findings underscore importance continued research on flavonoids promising candidates innovative therapies aimed at combating MDR infections.
Language: Английский
Citations
2
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101224 - 101224
Published: Feb. 1, 2025
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 6, 2024
, a Gram-positive bacterium, is predominant pathogen associated with various infections. The rapid emergence of antibiotic resistance has intensified the challenge managing fracture-related infections in severe osteoporotic patients. Rifampicin, potent antimicrobial agent employed against fracture and implant-related infections, necessitates combination therapies due to its susceptibility resistance. In this study, we explored potential baicalein, bioactive flavonoid from
Language: Английский
Citations
7
Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4534 - 4534
Published: Sept. 24, 2024
Quorum sensing (QS) is a bacterial cell-to-cell communication mechanism that plays an essential role in pathogenesis. QS governs behavior and controls biofilm formation, which turn contributes to antibiotic resistance. Therefore, identifying synthesizing novel compounds overcome inhibit formation are essential. Coumarins important plant-derived natural products with wide-ranging bioactivities extensive applications, including antibacterial, antifungal, anticoagulant, antioxidant, anticancer, anti-inflammatory properties. Additionally, coumarins capable of rewiring inhibition, leading higher susceptibility antimicrobial agents less this review, we aim provide overview formation. This review also discusses the synthesized controlling QS, inhibiting inducing synergy antibiotic–coumarin combinations. Hence, emphasizes potential coumarin act as antibacterial demonstrates their ability alleviate
Language: Английский
Citations
7
Published: Jan. 16, 2024
Ocular pathologies present significant challenges in achieving effective therapeutic re-sults due to various anatomical and physiological barriers. Natural products, such as flavonoids, alone or association with allopathic drugs, many therapeutical actions, including anti-cancer, anti-inflammatory, antibacterial action. However, their clinical employment is chal-lenging for scientists low water solubility. In this study, we designed a liquid formu-lation based on rutin/sulfobutylether-β-cyclodextrin (RTN/SBE-β-CD) inclusion complex treating ocular infections. The correct stoichiometry the accurate binding constant were de-termined by employing SupraFit software Uv-vis titration experiment. A deep physical-chemical characterization of RTN/SBE-β-CD was also performed; it con-firmed predominant formation stable (Kc, 9660 M−1) 1:1 molar ratio, high solubility 20 times (2.5 mg/mL) higher than free molecule (0.125 mg/mL), per-mitting dissolution solid within 30 min. NMR studies revealed involve-ment bicyclic flavonoid moiety complexation, which confirmed molecu-lar modeling studies. vitro, antibiofilm activity formulation assayed against Staphylococcus aureus Pseudomonas aeruginosa strains demonstrating sig-nificant components.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 5051 - 5051
Published: May 6, 2024
New antimicrobial molecules effective against Pseudomonas aeruginosa, known as an antibiotic-resistant "high-priority pathogen", are urgently required because of its ability to develop biofilms related healthcare-acquired infections. In this study, for the first time, anti-biofilm and anti-virulence activities a polyphenolic extract extra-virgin olive oil well purified oleocanthal oleacein, toward P. aeruginosa clinical isolates were investigated. The main result our study was activity mixture oleacein multidrug-resistant intermediately resistant strains isolated from patients with ventilator-associated pneumonia or surgical site infection. Specifically, (2.5 mM)/oleocanthal mM) significantly inhibited biofilm formation, alginate pyocyanin production, motility in both (p < 0.05); scanning electron microscopy analysis further evidenced inhibit bacterial cell adhesion production extracellular matrix. conclusion, results suggest potential application oleacein/oleocanthal management healthcare-associated infections, particularly era increasing resistance.
Language: Английский
Citations
3
Materials Today Communications, Journal Year: 2025, Volume and Issue: 42, P. 111507 - 111507
Published: Jan. 1, 2025
Language: Английский
Citations
0
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 115 - 115
Published: Jan. 22, 2025
Background/Objectives: Titanium dental implants, while highly successful, face challenges due to polymicrobial infections leading peri-implantitis and implant failure. Biofilm formation on surfaces is the primary cause of these infections, with factors such as matrix production cross-kingdom interactions contributing microbial accumulation bacterial fungal pathogens species. To combat this issue, naturally derived molecules have been reported overcome hurdle antimicrobial resistance against application conventional antibiotics antifungals. Methods: The present study aimed employ lichen-derived molecules, usnic acid (UA), retard development biofilms surface titanium kept in human artificial saliva (HAS) working a growth-supporting, host-mimicking media. Results: minimum inhibitory concentration UA HAS towards Candida albicans was >512 µg/mL, whereas Staphylococcus aureus Streptococcus mutans, it determined be 512 µg/mL. Whereas, standard growth media, MIC value S. mutans were 8 16 µg/mL; however, C. albicans, synergistically enhanced efficacy toward antifungals albicans. antibiofilm results depict fact that HAS, significantly reduced both mono-species aureus, mixed-species biofilm titanium. Conclusions: showed promising natural drug can control oral disease result implants.
Language: Английский
Citations
0