Myocardial ferroptosis may exacerbate the progression of atrial fibrillation through isolevuglandins DOI Creative Commons

Zhi‐Jie Yue,

X Li,

Zhan Shi

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 12, 2025

Atrial fibrillation (AF) poses a serious health threat to human and causes various adverse effects. It is currently the most common type of arrhythmia in adults. Long-term AF induces series heart-remodeling events, including mainly cardiac structural remodeling electrical remodeling, which further exacerbates AF. The oxidative stress has been shown play role inducing myocardial progression Recent studies have that ferroptosis occurs myocardium patients with AF, may constitute new mechanism for However, it unknown us how involved initiation maintenance so purpose this review elucidate possible underlying exacerbating We reviewed latest on speculate lipid peroxidation products isolevuglandins (IsoLGs), are produced during ferroptosis, be through two pathways: (1) IsoLGs inhibit degradation collagen, worsening fibrosis; (2) promote occurrence amyloidosis increase risk Consequently, we aim prevent atrial by either suppressing production or enhancing their clearance process myocardium, improving prognosis

Language: Английский

Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases DOI Open Access
Ying Liu, Wei Ding, Jianxun Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

Citations

53
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future DOI Creative Commons

Wenxi Fang,

Saiyang Xie, Wei Deng

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 21, 2024

Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved

Language: Английский

Citations

24
Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases DOI Creative Commons
Limin Liu, Yulin Ye, Rui Lin

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Ferroptosis is a newly discovered form of cell death that featured in wide range diseases. Exosome therapy promising therapeutic option has attracted much attention due to its low immunogenicity, toxicity, and ability penetrate biological barriers. In addition, emerging evidence indicates exosomes possess the modulate progression diverse diseases by regulating ferroptosis damaged cells. Hence, mechanism which cell-derived noncellular-derived target different through system Xc

Language: Английский

Citations

19
The crosstalk between exosomal miRNA and ferroptosis: A narrative review DOI
Zahra Nashtahosseini, Masoumeh Nejatollahi, Ahmad Fazilat

et al.

Biology of the Cell, Journal Year: 2025, Volume and Issue: 117(1)

Published: Jan. 1, 2025

Ferroptosis is a type of cell death that multiple mechanisms and pathways contribute to the positive negative regulation it. For example, increased levels reactive oxygen species (ROS) induce ferroptosis. ferroptosis unlike apoptosis, it not dependent on caspases, but iron. Exosomes are membrane-bound vesicles with size about 30 150 nm, contain various cellular components, including DNA, RNA, microRNAs (miRNAs), lipids, proteins, which genetically similar their cells origin. found in all bodily fluids, blood, saliva, urine. Cells often release exosomes after fusion membrane. They play an important role immune cell-cell communication. miRNAs, noncoding RNAs length 18 24 nucleotides, involved regulating gene expression transcription. Emerging data suggests exosomal miRNAs implicated pathophysiological cells, metastasis, drug resistance, death. In addition, functional studies have indicated can key modulation by Therefore, this review, given importance ferroptosis, we decided elucidate relationship between diseases.

Language: Английский

Citations

3
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1 DOI
Liming Yu, Xue Dong, Tao Huang

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(3-4), P. 607 - 626

Published: Jan. 28, 2023

Language: Английский

Citations

31
A novel tsRNA-5008a promotes ferroptosis in cardiomyocytes that causes atrial structural remodeling predisposed to atrial fibrillation DOI
Liangzhen Xie, Zewei Zhao,

Hao Xia

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 435(2), P. 113923 - 113923

Published: Jan. 6, 2024

Language: Английский

Citations

11
Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy DOI Creative Commons

Debiao Xiang,

Lili Zhou, Ruizhen Yang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2091 - 2112

Published: March 1, 2024

Abstract: Currently, cancer remains one of the most significant threats to human health. Treatment cancers challenging, despite implementation diverse therapies in clinical practice. In recent years, research on mechanism ferroptosis has presented novel perspectives for treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation membrane unsaturated fatty acids catalyzed iron ions. The rapid development bio-nanotechnology generated considerable interest exploiting iron-induced as new therapeutic target against cancer. This article provides comprehensive overview advancements at intersection and bionanotechnology. this respect, its relation are summarized. Furthermore, feasibility nano-drug delivery system based treatment introduced analyzed. Secondly, strategies inducing using nanodrug technology discussed, including promoting Fenton reactions, inhibiting glutathione peroxidase 4, reducing low levels, Xc − . Additionally, explores potential combined involving Finally, application prospects challenges nanoagents discussed. Keywords: cancers, ferroptosis, system,

Language: Английский

Citations

11
Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases DOI Creative Commons

Chenchen Jing,

Yupeng Wu, Yuzhu Zhang

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 11, 2025

As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In past decade, ferroptosis (a form iron-dependent regulated cell death) has been reported to contribute pathogenesis progression various diseases. The stability cardiomyocytes is crucial for maintenance normal cardiac activity. Ferroptosis detected many cardiovascular diseases (CVDs), including coronary heart disease, myocardial ischemia–reperfusion injury, failure, chemotherapy-induced damage. cardiomyocytes, epigenetic regulation post-translational modifications regulate expression ferroptosis-related factors, maintain homeostasis, participate CVDs. Currently, there no detailed mechanism explain relationship between this review, we provide initial summary core mechanisms with first focus on factors context common We anticipate that new insights into CVDs provided here will inspire development clinical interventions specifically target active sites these reducing harmfulness health.

Language: Английский

Citations

1
Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy DOI

Mobarakeh Ajam-Hosseini,

Sadegh Babashah

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

1
Implications of Crosstalk between Exosome-Mediated Ferroptosis and Diseases for Pathogenesis and Treatment DOI Creative Commons
Zixuan Zhou, Benshuai You, Cheng Ji

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 311 - 311

Published: Jan. 13, 2023

Ferroptosis is a type of iron-dependent cell death caused by ferrous iron overload, reactive oxygen species generation through the Fenton reaction, and lipid peroxidation, leading to antioxidative system dysfunction and, ultimately, membrane damage. The functional role ferroptosis in human physiology pathology considered cause or consequence diseases. Circulating exosomes mediate intercellular communication organ crosstalk. They not only transport proteins nucleic acids derived from parental cells but also serve as vehicles for targeted delivery exogenous cargo. Exosomes regulate delivering biological material recipient cell, affecting ferroptosis-related proteins, transporting ferritin-bound out cell. This review discusses pathogenesis mediated endogenous therapeutic potential In addition, this explores exosome-mediated diseases with an emphasis on strategies engineering therapy.

Language: Английский

Citations

18