Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication DOI Creative Commons

Ellie Swords,

Breandán N. Kennedy, Valentina Tonelotto

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Uveal melanoma (UM) is the most common primary intraocular tumour in adults. Local resection, radiation therapy, and enucleation are current first-line, UM treatments. However, regardless of treatment received, around 50% patients will develop metastatic disease within five to 7 years. In largest published series unselected with (mUM), median survival time after diagnosis metastasis was 3.6 months, less than 1% surviving beyond 5 Approved drugs for mUM include systemic tebentafusp-tebn or isolated hepatic perfusion (IHP) melphalan. these only available a subset improve by few highlighting urgent need new Accurately predicting which at high risk metastases also crucial. Researchers developing gene expression signatures create reliable prognostic models aimed improving patient follow-up strategies. this review we discuss evidence supporting ferroptosis, non-apoptotic form cell death, as potential novel target prognosticator UM.

Language: Английский

Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology DOI Creative Commons

Emile M. Youssef,

Brandon Fletcher,

Dannelle Palmer

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 13, 2025

Gene therapy has long been a cornerstone in the treatment of rare diseases and genetic disorders, offering targeted solutions to conditions once considered untreatable. As field advances, its transformative potential is now expanding into oncology, where personalized therapies address immune-related complexities cancer. This review highlights innovative therapeutic strategies, including gene replacement, silencing, oncolytic virotherapy, CAR-T cell therapy, CRISPR-Cas9 editing, with focus on their application both hematologic malignancies solid tumors. CRISPR-Cas9, revolutionary tool precision medicine, enables precise editing cancer-driving mutations, enhancing immune responses disrupting tumor growth mechanisms. Additionally, emerging approaches target ferroptosis—a regulated, iron-dependent form death—offering new possibilities for selectively inducing death resistant cancers. Despite significant breakthroughs, challenges such as heterogeneity, evasion, immunosuppressive microenvironment (TME) remain. To overcome these barriers, novel like dual-targeting, armored cells, combination checkpoint inhibitors ferroptosis inducers are being explored. rise allogeneic “off-the-shelf” offers scalable more accessible options. The regulatory landscape evolving accommodate advancements, frameworks RMAT (Regenerative Medicine Advanced Therapy) U.S. ATMP (Advanced Therapy Medicinal Products) Europe fast-tracking approval therapies. However, ethical considerations surrounding CRISPR-based editing—such off-target effects, germline ensuring equitable access—remain at forefront, requiring ongoing oversight. Advances non-viral delivery systems, lipid nanoparticles (LNPs) exosomes, improving safety efficacy By integrating innovations addressing concerns, poised revolutionize cancer treatment, providing durable, effective,

Language: Английский

Citations

3
MFAP4 is a novel prognostic biomarker in glioma correlating with immunotherapy resistance and ferroptosis DOI Creative Commons

Yuanhao Lv,

Ying Gao,

Wenyu Di

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

Glioma, an aggressive brain tumor, poses a challenge in understanding the mechanisms of treatment resistance, despite promising results from immunotherapy. Genes associated with immunotherapy resistance were identified by analyzing The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), and Gene Expression Omnibus (GEO) database. In addition, gene set enrichment analysis (GSEA) was utilized to reveal relevant signaling pathways. Co-expression, differential expression functional analyses performed using TCGA-GBM/LGG, TIMER 2.0, MetScape, GTEx LinkedOmics databases. Relationships immune infiltration, ferroptosis checkpoint genes assessed. mutations explored cBioPortal. Logistic regression, Lasso analysis, Receiver Operating Characteristic (ROC), Kaplan-Meier Nomogram modeling assessed correlation between MFAP4 clinicopathological features gliomas. By different datasets, we found that aberrantly overexpressed gliomas correlated poor independent prognostic indicator significantly glioma progression. We also pathway explore its biological functions potential molecular elevated tissues compared controls. MFAP4-related showed pathways involving cytokines. Significant associations levels, ferroptosis, tissues. levels stage, histological type, 1p/19q status, independently predicted overall survival (OS), disease-specific (DSS) progression-free interval (PFI). is effective distinguishing tumor tissue normal tissue. Furthermore, Spearman Correlation emphasizes significant relationship ferroptosis-related genes. Our study demonstrated correlates adverse features. has relevance regulating both immunity iron death, cellular function assays have promotes proliferation, migration, invasion cells.

Language: Английский

Citations

1
The Current Status and Future Directions on Nanoparticles for Tumor Molecular Imaging DOI Creative Commons
Caiyun Yin,

Peiyun Hu,

Lijing Qin

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9549 - 9574

Published: Sept. 1, 2024

Molecular imaging is an advanced technology that utilizes specific probes or markers in conjunction with cutting-edge techniques to observe and analyze the localization, distribution, activity, interactions of biomolecules within living organisms. Tumor molecular imaging, by enabling visualization quantification characteristics tumor cells, facilitates a deeper more comprehensive understanding tumors, providing valuable insights for early diagnosis, treatment monitoring, cancer biology research. However, image quality still requires improvement, nanotechnology has significantly propelled advancement imaging. Currently, nanoparticle-based technologies encompass radionuclide fluorescence magnetic resonance ultrasound photoacoustic multimodal among others. As our microenvironment deepens, design nanoparticle also evolved, offering new perspectives expanding applications Beyond diagnostics, there marked trend towards integrated diagnosis therapy, image-guided playing pivotal role. This includes surgery, photodynamic chemodynamic therapy. Despite continuous advancements innovative developments many these remain experimental stage require breakthroughs before they can be fully into clinical practice.

Language: Английский

Citations

7
Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Language: Английский

Citations

0
Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies DOI Creative Commons
Dandan Guo, Songhua Cai,

Lvdan Deng

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 23, 2025

Ferroptosis is a distinct form of iron-dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, various signaling pathways, autophagy, have been demonstrated to influence the induction progression ferroptosis. Recent investigations elucidated that ferroptosis plays crucial role in pathogenesis pulmonary disorders, lung injury, chronic obstructive disease, fibrosis, asthma. increasingly recognized as promising novel strategy for cancer treatment. Various immune cells within tumor microenvironment, CD8+ T cells, macrophages, regulatory natural killer dendritic shown induce modulate process through regulation metabolism pathways. Conversely, can reciprocally alter metabolic environment, leading activation or inhibition functions, thereby modulating responses. This paper reviews molecular mechanism describes discusses connection between microenvironment diseases, development prospect their interaction treatment diseases.

Language: Английский

Citations

0
Caspase-independent cell death in lung cancer: from mechanisms to clinical applications DOI Creative Commons
Gaurav Gupta,

Vijaya Paul Samuel,

M M Rekha

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Caspase-independent cell death (CICD) has recently become a very important mechanism in lung cancer, particular, to overcome critical failure apoptotic that is common disease progression and treatment failures. The pathways involved CICD span from necroptosis, ferroptosis, mitochondrial dysfunction, autophagy-mediated death. Its potential therapeutic applications have been highlighted. Glutathione peroxidase 4 (GPX4) inhibition-driven ferroptosis drug resistance non-small cancer (NSCLC). In addition, necroptosis involving RIPK1 RIPK3 causes tumor modulation of immune responses the microenvironment (TME). Mitochondrial are for through metabolic redox homeostasis. Ferroptosis amplified by reactive oxygen species (ROS) lipid peroxidation cells, depolarization induces oxidative stress leads mitochondria-mediated autophagy, or mitophagy, results clearance damaged organelles under conditions, while this function also linked when dysregulated. role autophagy regulated ATG proteins PI3K/AKT/mTOR pathway dual: suppress sensitize cells therapy. A promising approach enhancing outcomes involves targeting mechanisms CICD, including inducing SLC7A11 inhibition, modulating ROS generation, combining inhibition with chemotherapy. Here, we review molecular underpinnings particularly on their transform treatment.

Language: Английский

Citations

0
The critical role of ferroptosis in virus-associated hematologic malignancies and its potential value in antiviral-antitumor therapy DOI Creative Commons
Miao Miao, Yue‐Lei Chen, Xuehan Wang

et al.

Virulence, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 29, 2025

Epstein-Barr Virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and human T-cell leukemia virus type 1 (HTLV-1) are key infectious agents linked to the development of various hematological malignancies, including Hodgkin's lymphoma, non-Hodgkin's adult leukemia/lymphoma. This review highlights critical knowledge gaps in understanding role ferroptosis, a novel form cell death, virus-related tumors. We focus on how ferroptosis influences host response these viral infections, revealing groundbreaking mechanisms by which three viruses differentially regulate core pathways such as iron homeostasis, lipid peroxidation, antioxidant systems, thereby promoting malignant transformation cells. Additionally, we explore potential antiviral drugs modulators treatment virus-associated malignancies.

Language: Английский

Citations

0
Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds DOI Creative Commons

Qiuran Liang,

Yuehui Wang,

Yili Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.

Language: Английский

Citations

3
Strategic design and development of a siderophore mimic: Pioneering anticancer therapy via ROS generation and ferroptosis DOI
Abhishek Panwar,

Anushree Lye,

Dulal Musib

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(29), P. 12119 - 12127

Published: Jan. 1, 2024

We designed a tris-catecholate-based siderophore mimic, H

Language: Английский

Citations

1
Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies DOI Creative Commons
Chao Ma, Haoyu Li, Shuwen Lu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Thyroid-associated ophthalmopathy (TAO) is an inflammatory orbital disease associated with autoimmune thyroid disorders. Owing to the ambiguous nature of pathogenesis, contemporary pharmacological treatment strategies predominantly involve use glucocorticoids and immunosuppressants. However, adverse effects these agents in clinical practice necessitate further investigation into disease's pathogenesis identification novel therapeutic targets interventions. Recent studies suggest that ferroptosis, a form regulated cell death, may play role TAO pathogenesis. This review aims explore involvement ferroptosis evaluate its potential as target. Key topics include epidemiology, manifestations, pathophysiology TAO, along molecular mechanisms ferroptosis. Evidence supporting implications targeting this pathway are also discussed, alongside challenges future directions emerging research area.

Language: Английский

Citations

1