The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: June 20, 2022

In the last two decades, considerable interest has been shown in understanding development of gut microbiota and its internal external effects on intestine, as well risk factors for cardiovascular diseases (CVDs) such metabolic syndrome. The intestinal plays a pivotal role human health disease. Recent studies revealed that can affect host body. CVDs are leading cause morbidity mortality, patients favor death over chronic kidney For function host, molecules have to penetrate epithelium or surface cells host. Gut utilize trimethylamine, N-oxide, short-chain fatty acids, primary secondary bile acid pathways. By affecting these living cells, heart failure, atherosclerosis, hypertension, myocardial fibrosis, infarction, coronary artery Previous relation stroke pathogenesis consequences provide new therapeutic prospects. This review highlights interplay between metabolites addresses related interventions treatment CVDs.

Language: Английский

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Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113217 - 113217

Published: June 6, 2022

Diabetes mellitus (DM) is a metabolic syndrome. has become more common in recent years. Chemically generated drugs are used to lessen the effects of DM and its following repercussions due unpleasant side such as weight gain, gastrointestinal issues, heart failure. On other hand, medicinal plants could be good source anti-diabetic medications. This article aims determine any plant matrix's positive potential. Food restriction, physical activity, use antidiabetic plant-derived chemicals all being promoted effective ways manage diabetes because they less expensive have fewer or no effects. review focuses on plants, along with their bioactive constituent, chemically characterization, plant-based diets for management. There minimal scientific data about mechanism action product been found. The purpose this highlight compounds that properties. It also provides researchers may build future strategies, identifying promising molecules make management easier.

Language: Английский

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Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113305 - 113305

Published: June 16, 2022

Language: Английский

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Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Molecules, Journal Year: 2022, Volume and Issue: 27(7), P. 2165 - 2165

Published: March 27, 2022

Breast cancer (BrCa) is the most common malignancy in women and second significant cause of death from cancer. BrCa one challenging malignancies to treat, it accounts for a large percentage cancer-related deaths. The number cases requiring more effective therapy has increased dramatically. Scientists are looking productive agents, such as organic combinations, prevention treatment because chemotherapeutic agents linked metastasis, resistance drugs, side effects. Natural compounds produced by living organisms promote apoptosis inhibit slowing spread As result, these may delay BrCa, enhancing survival rates reducing deaths caused BrCa. Several natural production while lowering cell proliferation triggering death. compounds, addition therapeutic approaches, efficient potential treating This review highlights demonstrated various studies have anticancer properties cells. Future research into biological anti-BrCa pave way new era treatment, with drugs playing key role improving patient rates.

Language: Английский

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Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 22, 2022

Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in solid mass cells known as tumor or liquid cancer. It leading cause mortality worldwide, and number cancer patients has been increasing at an alarming rate, with estimated 20 million cases expected 2030. Thus, use complementary alternative therapeutic techniques that can help prevent subject increased attention. Garlic, most widely used plant medicinal product, exhibits wide spectrum biological activities, including antibacterial, hypo-lipidemic, antithrombotic, anticancer effects. Diallyl disulfide (DADS) major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated DADS anti-tumor activity against many types gynecological cancers (cervical cancer, ovarian cancer), hematological (leukemia, lymphoma), lung neural skin prostate gastrointestinal tract associated (esophageal gastric colorectal hepatocellular cell line, etc. The mechanisms behind action include epithelial-mesenchymal transition (EMT), invasion, migration. This article aims to review available information regarding anti-cancer potential DADS, well summarize its action, bioavailability, pharmacokinetics from published clinical toxicity studies.

Language: Английский

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A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

Pharmacological Research, Journal Year: 2022, Volume and Issue: 184, P. 106398 - 106398

Published: Aug. 19, 2022

Language: Английский

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Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(7), P. 4384 - 4404

Published: May 12, 2022

Language: Английский

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Naphthoquinones and derivatives as potential anticancer agents: An updated review

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 368, P. 110198 - 110198

Published: Sept. 27, 2022

Language: Английский

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Nano-delivery systems for food bioactive compounds in cancer: prevention, therapy, and clinical applications

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(2), P. 381 - 406

Published: Aug. 8, 2022

Bioactive compounds represent a broad class of dietary metabolites derived from fruits and vegetables, such as polyphenols, carotenoids glucosinolates with potential for cancer prevention. Curcumin, resveratrol, quercetin, β-carotene have been the most widely applied bioactive in chemoprevention. Lately, many approaches to encapsulating components nano-delivery systems improved biomolecules' stability targeted delivery. In this review, we critically analyze compounds, including polymeric nanoparticles (NPs), solid lipid (SLN), nanostructured carriers (NLC), liposomes, niosomes, nanoemulsions (NEs) use therapy. Efficacy studies nanoformulations using cell lines vivo models updated human clinical trials are also discussed. Nano-delivery were found improve therapeutic efficacy molecules against various types (e.g., breast, prostate, colorectal lung cancer) mainly due antiproliferation pro-apoptotic effects tumor cells. Furthermore, some promised combination therapy standard chemotherapeutic agents, increased efficiency fewer side effects. These opportunities identified developed ensure more excellent safety novel herbal medicines enabling insights designing

Language: Английский

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Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3798 - 3798

Published: June 13, 2022

Immunotherapy, which stimulates the body’s immune system, has received a considerable amount of press in recent years because its powerful benefits. Cancer immunotherapy shown long-term results patients with advanced disease that are not seen traditional chemotherapy. Immune checkpoint inhibitors, cytokines like interleukin 2 (IL-2) and interferon-alpha (IFN), cancer vaccine sipuleucel-T have all been licensed approved by FDA for treatment various cancers. These treatments boost anticancer responses stimulating system. As result, they potential to cause serious, even fatal, inflammatory immune-related side effects one or more organs. inhibitors (ICPIs) chimeric antigen receptor (CAR) T-cell therapy two increasingly being used treat cancer. Following their widespread usage clinic, wave adverse events (irAEs) impacting virtually every system raised concerns about unpredictability randomness. Despite fact majority minimal should be addressed prudence, risk life-threatening complications exists. Although most small treated caution, toxicities underestimated, especially given subtle unusual indications make early detection difficult. Treatment these issues is difficult necessitates multidisciplinary approach involving only oncologists but also other internal medicine doctors guarantee quick diagnosis treatment. This study’s purpose give fundamental overview cancer-related effect management strategies.

Language: Английский

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