Exploring the potential function of trace elements in human health: a therapeutic perspective

Molecular and Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 478(10), P. 2141 - 2171

Published: Jan. 13, 2023

Language: Английский

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Phenolic compounds and antioxidants activity of banana peel extracts: Testing and optimization of enzyme-assisted conditions

Measurement Food, Journal Year: 2023, Volume and Issue: 10, P. 100085 - 100085

Published: March 16, 2023

Banana processing industry generates a large number of by-products mainly constituted by peel that can be good source bioactive polyphenols. Extraction phenolic compounds using optimum extraction conditions enhances the yield and quality desired compounds. Meanwhile, well-chosen optimization procedure has ability to reduce amount time, solvent, temperature needed, which will consequently lower overall process cost. In this study, enzyme-assisted was evaluated for maximum from banana peels three enzymes viscozyme® L, cellulase, pectinase. The were achieved enzyme concentration (0–2%, v/v), time (1–12 hrs), (35–60 °C), solute-liquid ratio (1:5–1:30, w/v) at pH 4.0. responses such as total phenol content (TPC), flavonoid (TFC), DPPH ABTS inhibition activity, α-glucosidase inhibitory activity determined spectrophotometric analysis. Viscozyme® L found more effective compared pectinase, condition obtained with 1.0% concentration, 9 hrs 55 °C temperature, 1:25. values TPC, TFC, ABTS, optimized 25.37 mg GAE/g DM, 13.99 QE/g 81.59%, 88.25%, 74.67% scavenging ability, respectively. Therefore, viscozyme-assisted could promising method utilization valuable ingredients food pharmaceuticals.

Language: Английский

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Acupuncture-adjuvant therapies for treating perimenopausal depression: A network meta-analysis

Medicine, Journal Year: 2023, Volume and Issue: 102(33), P. e34694 - e34694

Published: Aug. 18, 2023

Background: The issues related to the treatment of perimenopausal depression (PMD) are side effects antidepressants and hormone replacement therapy. aim this study was assess efficiency safety acupuncture moxibustion in PMD patients. Methods: Databases, namely PubMed, Cochrane Library, Web Science, EMBASE, CNKI, CBM, VIP, WanFang, were reviewed for randomized controlled trials dated between database inception November 22, 2022. primary outcomes efficacy rate Hamilton Depression Scale score. secondary levels follicle-stimulating hormone, luteinizing estradiol Kupperman Odds ratios (ORs) generated as effect size dichotomous outcomes, while standard mean difference (SMD) ± deviation used continuous outcomes. Matrices developed demonstrate pairwise comparisons regimens each endpoint. Utilizing Review Manager (RevMan) 5.3, Stata 16.0 SPSS 21, data analyzed. Results: In total, 27 studies involving 2269 patients 8 therapeutic measures incorporated into network meta-analysis (NMA). NMA showed that warm (OR = 1.55, 95% CI: 1.00–2.44), electroacupuncture 1.34, 1.00–1.8), abdominal 1.19, 0.73–1.96), common 1.4, 0.9–2.17) more effective than fluoxetine + menopausal PMD. also that, based on score, other 4 acupuncture-related treatments, i.e., (SMD −1.22, −2.34 −0.09), thread embedding −1.31, −2.21 −0.40), −1.33, −2.42 −0.24), −1.46, −2.26 −0.66). cumulative ranking probability (SUCRA) (99.6%) best method. Conclusions: findings may help therapists choose therapy treating furnish reliable evidence guidelines.

Language: Английский

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Valorization of Solanum melongena L. crop by-products: phenolic composition and in vitro antioxidant, antidiabetic, anti-inflammatory, cytotoxic, and antimicrobial properties

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 27

Published: Aug. 22, 2022

Based on the diverse physiological influence, impact of glial cells has become much more evident neurological illnesses, resulting in origins many diseases appearing to be convoluted than previously happened. Since disorders are often random and unknown, hence construction animal models is difficult build, representing a small fraction people with gene mutation. As result, an immediate necessity grown work within vitro techniques for examining these illnesses. scientific community recognizes cell-autonomous contributions variety central nervous system therapeutic involving stem treating gaining traction. The use derived from sources increasingly being used replace both neuronal tissue. brain’s energy demands necessitate reliance neurons order it function properly. Furthermore, have functions terms regulating their own metabolic activities, as well collaborating via secreted signaling or guidance molecules, forming complex network neuron-glial connections health sickness. Emerging data reveals that changes can cause morphological functional conjunction dysfunction under disease situations, highlighting importance neuron-glia interactions pathophysiology In this context, required improve our understanding mechanisms create potential novel therapeutics. According research, synaptic malfunction one features various mental diseases, acting key ingredients not only synapse formation, growth, plasticity but also neuroinflammation homeostasis which creates critical capacity focused sensory system. goal review article elaborate state-of-the-art information few cell types situated (CNS) highlight role onset progression disorders.

Language: Английский

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Emerging Promise of Computational Techniques in Anti-Cancer Research: At a Glance

Bioengineering, Journal Year: 2022, Volume and Issue: 9(8), P. 335 - 335

Published: July 25, 2022

Research on the immune system and cancer has led to development of new medicines that enable former attack cells. Drugs specifically target destroy cells are horizon; there also drugs use specific signals stop multiplying. Machine learning algorithms can significantly support increase rate research complicated diseases help find remedies. One area medical study could greatly benefit from machine is exploration genomes discovery best treatment protocols for different subtypes disease. However, developing a drug time-consuming, complicated, dangerous, costly. Traditional production take up 15 years, costing over USD 1 billion. Therefore, computer-aided design (CADD) emerged as powerful promising technology develop quicker, cheaper, more efficient designs. Many technologies methods have been introduced enhance productivity analytical methodologies, they become crucial part many programs; scanning programs, example, ligand screening structural virtual techniques hit detection optimization. In this review, we examined various types computational focusing anticancer drugs. Machine-based in basic translational reach levels personalized medicine marked by speedy advanced data analysis still beyond reach. Ending know it means ensuring every patient access safe effective therapies. Recent developments had large remarkable impact yielded useful insights into field therapy. With an emphasis medications, covered components paper. Transcriptomics, toxicogenomics, functional genomics, biological networks only few examples bioinformatics used forecast medications combinations based multi-omics data. We believe general review databases now available today will be beneficial creation approaches.

Language: Английский

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Antidiabetic Properties of Plant Secondary Metabolites

Metabolites, Journal Year: 2023, Volume and Issue: 13(4), P. 513 - 513

Published: April 3, 2023

The prevalence of diabetes mellitus is one the major medical problems that modern world currently facing. Type 1 and 2 both result in early disability death, as well serious social financial problems. In some cases, synthetic drugs can be quite effective treatment diabetes, though they have side effects. Plant-derived pharmacological substances are particular interest. This review aims to study antidiabetic properties secondary plant metabolites. Existing research articles on investigation metabolites, methods their isolation, use mellitus, separate confirm relevance topic expand understanding mechanisms action were analyzed for this review. structure plants used including antioxidants, polysaccharides, alkaloids, insulin-like substances, lowering blood sugar, presented. main advantages disadvantages using phytocomponents treat outlined. types complications effects medicinal them described. phytopreparations human gut microbiota discussed. Plants with a general tonic effect, containing plants-purifiers, rich vitamins, organic acids, etc. been shown play an important role type prevention its complications.

Language: Английский

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Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Life, Journal Year: 2023, Volume and Issue: 13(9), P. 1831 - 1831

Published: Aug. 29, 2023

Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to diverse compositions pharmacological effects. Algae, in particular, garnered attention potential source of bioactive compounds with anti-diabetic properties. This review offers comprehensive overview algae-derived natural management, highlighting recent developments future prospects. It underscores the pivotal role care delves into diversity algae, constituents, underlying mechanisms efficacy. Noteworthy algal substantial are briefly elucidated, along specific contributions addressing distinct aspects diabetes. The challenges limitations inherent utilizing algae interventions examined, accompanied by strategic recommendations optimizing effectiveness. By these considerations, this aims chart course research refining algae-based approaches. Leveraging multifaceted activities chemical components holds promise pursuit novel antidiabetic treatments. Through continued fine-tuning interventions, burden could be mitigated, ultimately leading enhanced patient outcomes.

Language: Английский

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Synthesis and inhibitory activity of euparin derivatives as potential dual inhibitors against α-glucosidase and protein tyrosine phosphatase 1B (PTP1B)

Fitoterapia, Journal Year: 2023, Volume and Issue: 169, P. 105596 - 105596

Published: June 25, 2023

Language: Английский

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Nrf2-mediated therapeutic effects of dietary flavones in different diseases

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 12, 2023

Oxidative stress (OS) is a pathological status that occurs when the body’s balance between oxidants and antioxidant defense systems broken, which can promote development of many diseases. Nrf2, redox-sensitive transcription encoded by NFE2L2, master regulator phase II enzymes cytoprotective genes. In this context, Nrf2/ARE signaling be compelling target against OS-induced Recently, natural regulators like dietary flavones have shown therapeutic potential in various acute chronic diseases such as diabetes, neurodegenerative diseases, ischemia-reperfusion injury, cancer. review, we aim to summarize nrf2-mediated protective effects different conditions. Firstly, retrospected mechanisms how regulate pathway introduced mediator role Nrf2 plays inflammation apoptosis. Then review evidence modulated prevent experimental models. Based on these literature, found could expression below: 1) dissociating binding Keap1 via PKC-mediated phosphorylation P62-mediated autophagic degradation; 2) regulating nuclear translocation kinases AMPK, MAPKs, Fyn; 3) decreasing ubiquitination degradation activating sirt1 PI3K/AKT-mediated GSK3 inhibition; 4) epigenetic alternation demethylation at promoter region histone acetylation. conclusion, targeting promising agents for OS-related disorders. However, there lack investigations human subjects, new drug delivery improve flavones’ treatment efficiency still need developed.

Language: Английский

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