Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6687 - 6687

Published: Sept. 18, 2023

Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and oxide nanoparticles stand out as promising candidates for multitude applications. This article aims provide contemporary insights into the perspectives challenges regarding use medicine. It summarises biomedical potential copper-based nanoformulations, including progress early-stage research, evaluate mitigate toxicity nanomaterials. The discussion covers prospects nanomaterials context their successful clinical translation. also addresses safety concerns, emphasizing need assessments nanomedicines. However, attention is needed solve current such biocompatibility controlled release. Ongoing research collaborative efforts overcome these obstacles are discussed. analysis guidance safe effective integration practice, thereby advancing recent literature highlighted multifaceted associated with translation from laboratory clinic. In particular, remains formidable hurdle, requiring innovative ensure seamless human body. Additionally, achieving release therapeutic agents poses complex challenge that requires meticulous engineering precise design.

Language: Английский

---

Biosynthesis of ZnO NPs from pumpkin seeds’ extract and elucidation of its anticancer potential against breast cancer

Nanotechnology Reviews, Journal Year: 2022, Volume and Issue: 11(1), P. 2714 - 2725

Published: Jan. 1, 2022

Abstract The cost-effective and environmental friendly biosynthesis of metal nanoparticles is becoming increasingly important in biomedical science. This study biosynthesized zinc oxide (ZnO NPs) from pumpkin seed extract assessed its anticancer activity by using different molecular biology experiments human breast cancer (MDA-MB-231) cell lines. well-known analytical techniques, such as UV-visible spectrophotometry, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission microscopy (TEM), were used to confirm the synthesis characterize morphological structural features biogenic ZnO NPs. formation spherical with an average size 50–60 nm was recorded TEM. We observed dose-dependent increase cytotoxicity NPs MDA-MB-231 line a 50% inhibitory concentration 10 µg/mL. Moreover, also showed significant morphology changes, apoptosis induction, reactive oxygen species production at highest tested concentration. cellular adhesion migration assay indicated death inhibition cells response NPs’ treatment. These results clearly demonstrated potential against studied line. However, extension this recommended models and, based on results, vivo validation should be done.

Language: Английский

---

Green synthesis and characterization of copper nanoparticles using Phragmanthera austroarabica extract and their biological/environmental applications

Sustainable materials and technologies, Journal Year: 2022, Volume and Issue: 35, P. e00540 - e00540

Published: Dec. 5, 2022

Language: Английский

---

Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 24, 2023

The present study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on MCF-7 and SKBR3 cancer cells. X-ray diffraction, ultraviolet-visible spectroscopy, Fourier-transform infrared photoelectron transmission electron microscopy, field-emission scanning energy-dispersive X-ray, dynamic light scattering, zeta potential techniques were used to characterize BC-CuONPs. This also investigated cellular molecular processes NPs' anti-proliferative apoptotic properties human breast cells compared them commercial pharmaceutical tamoxifen. size spherical NP was from 5 47 nm with negative potential. MTT results showed great cytotoxic effect BC-CuONPs against inhibited growth in a time- dose-dependent manner. up-regulation BCL2-associated X (BAX), cyclin dependent kinase inhibitor 1A (P21), Caspase 3 (CASP3), 9 (CASP9), down-regulation BCL2 apoptosis regulator (BCL2), Annexin V-FITC/propidium iodide, reactive oxygen species (ROS) generation suggested that had significant impact when control. Scratch tests vascular endothelial factor receptor gene (VEGF) demonstrated anti-metastatic activity. cell cycle analysis Cyclin D1 (CCND1) 4 (CDK4) revealed arrested sub-G1 phase. Finally, secondary metabolites supernatant could form CuONPs, biogenic anti-metastasis while having less adverse effects normal Therefore, synthesized CuONPs using B. can be shown as candidate for new therapeutic strategy management.

Language: Английский

---

Targeting copper metabolism: a promising strategy for cancer treatment

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: July 26, 2023

Copper is an essential micronutrient that plays a critical role in many physiological processes. However, excessive copper accumulation cancer cells has been linked to tumor growth and metastasis. This review article explores the potential of targeting metabolism as promising strategy for treatment. Excessive associated with By disrupting homeostasis inducing cell death through copper-dependent mechanisms (cuproplasia cuprotosis, respectively), therapies can be developed improved efficacy reduced side effects. The discusses biological processes, such angiogenesis, immune response, redox homeostasis. Various approaches treatment are examined, including use enzymes, copper-based compounds, cuprotosis-related genes or proteins. also strategies like chelation therapy nanotechnology targeted delivery copper-targeting agents. understanding intricate network cuprotosis its interactions microenvironment system, new targets identified, leading outcomes. Overall, this comprehensive highlights significant effective approach treatment, while providing valuable insights into current state research field.

Language: Английский

---

Biogenic Synthesis of Copper Nanoparticles: A Systematic Review of Their Features and Main Applications

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4838 - 4838

Published: June 18, 2023

Nanotechnology is an innovative field of study that has made significant progress due to its potential versatility and wide range applications, precisely because the development metal nanoparticles such as copper. Nanoparticles are bodies composed a nanometric cluster atoms (1–100 nm). Biogenic alternatives have replaced their chemical synthesis environmental friendliness, dependability, sustainability, low energy demand. This ecofriendly option medical, pharmaceutical, food, agricultural applications. When compared counterparts, using biological agents, micro-organisms plant extracts, reducing stabilizing agents shown viability acceptance. Therefore, it feasible alternative for rapid scaling-up processes. Several research articles on biogenic copper been published over past decade. Still, none provided organized, comprehensive overview properties Thus, this systematic review aims assess decade regarding antioxidant, antitumor, antimicrobial, dye removal, catalytic activities biogenically synthesized scientific methodology big data analytics. Plant extract (bacteria fungi) addressed agents. We intend assist community in comprehending locating helpful information future or application development.

Language: Английский

---

Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215754 - 215754

Published: March 12, 2024

The science of nanotechnology has been proposed as a factor main change in the field cancer diagnosis and treatment. challenges common clinical treatment breast can be dominate by proof targeting cells nanoscale drug delivery system. Due to specific properties nanoparticles such biocompatibility, minimum toxicity, excellent stability, multifunctional encapsulations therapeutic agents, increased permeability retention effect, selective targeting, they apply for therapy. Multidrug resistance many chemotherapy drugs is one conventional that overcome nanoparticles. However, vivo vitro studies limited this field, number approved nano formulation not significantly over years. Successful translation nanomedicines arduous requiring considerable preclinical tests. Two-dimensional (2D) monolayer cell cultures animal models, which are routinely used research discovery/screening seem inadequate. To address challenge, biomimetic three-dimensional (3D) tumor models like spheroids, organoids, scaffolds/hydrogels, bioprinted, microfluidic chips have established using engineering approach. Taking physiopathology microenvironment into account, potential enhance disease modeling drug/nanomedicine screening. development 3D comprised patient's own cancer, stromal, immune exploited promising platform provide personalized

Language: Английский

---

Unveiling sustainable, greener synthesis strategies and multifaceted applications of copper oxide nanoparticles

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1305, P. 137788 - 137788

Published: Feb. 11, 2024

Language: Английский

---

One-Pot Biopreparation of Trimetallic ZnO–MgO–CuO Nanoparticles: Enhanced Cytotoxicity, Antibacterial Activities and Molecular Docking Studies

Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(4), P. 1963 - 1980

Published: Jan. 29, 2024

Abstract Nowadays, metal oxide nanoparticles (MO NPs) are powerful tools for biological applications due to their distinctive features. Moreover, the efficacy of multimetallic NPs is more fascinating because structural modifications and synergistic effects. This study utilized one-pot green route fabricate trimetallic ZnO-MgO-CuO (ZMC) employing a greener reducing agent from Artemisia abyssinica leaf extract (AALE). The crystal structure, size, compositions, shapes, external topology ZMC were characterized by Fourier transform infrared (FTIR) , UV–Visible (UV–vis), X-ray diffraction (XRD) scanning electron microscopy (SEM), energy-dispersive (EDX) transmission combined with selected area (TEM/HRTEM-SAED). outcomes suggested that bio-prepared highly crystalline have hexagonal structures lattice monoclinic symmetry spherical morphology average particle sizes 14.67 15.13 nm, respectively . Using MTT assay, demonstrated high inhibition percentage (94.37 ± 0.14 at 250 mg/mL) an IC 50 value 24.83 mg/mL MCF-7 cell lines. in-vitro antibacterial potential has been evaluated against four bacterial (Gram-positive Gram-negative) strains highest zone (35 0.03 mm ) S. aureus strain lowest (31 0.11 E. coli strain. also shown strong molecular binding interactions amino acids estrogen receptor (ERα), energies − 9.85, 12.31, 6.04 kcal/mole, respectively. Graphical

Language: Английский

---

Antibacterial Properties of Copper Oxide Nanoparticles (Review)

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11563 - 11563

Published: Oct. 28, 2024

The use of metal and oxide nanoparticles is frequently regarded as a potential solution to the issue bacterial antibiotic resistance. Among proposed range with antibacterial properties, copper are particular interest. Although properties have been known for considerable period time, studies on effects nanomaterials respect biological systems attracted attention in recent years. This review presents summary nanoparticles, mechanisms by which effect realized, key reported methods modifying these improve their activity. A comparative analysis effectiveness presented depending type microorganism, shape Gram classification bacteria based data from published sources. In addition, addresses activities including antifungal cytotoxic well “antioxidant” According conducted literature data, it can be concluded that significant bacteriostatic wide microorganisms and, some cases, contribute inhibition fungal growth. At same sensitivity Gram-positive was often higher than Gram-negative bacteria.

Language: Английский

---