Circulating non-coding RNA in type 1 diabetes mellitus as a source of potential biomarkers – An emerging role of sex difference DOI Creative Commons
Lucyna Stachowiak, Weronika Kraczkowska, Aleksandra Świercz

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 736, P. 150482 - 150482

Published: July 31, 2024

Non-coding RNAs (ncRNAs), such as microRNA, long non-coding RNA, and circular are considered essential regulatory molecules mediating many cellular processes. Moreover, an increasing number of studies have investigated the role ncRNAs in cancers various metabolic disorders, including diabetes mellitus. Interestingly, some circulating ncRNA detected body fluids may serve novel biomarkers. There is still a lack conventional biomarkers that detect early stage type 1 Many RNA show aberrant expression patients compared to healthy individuals. However, most focused on microRNA rather than or RNA. In addition, few evaluated sex differences Therefore, this article summarises current knowledge about potential for explores effects

Language: Английский

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective DOI Creative Commons
Yifan Liu,

Renjie Pan,

Yuzhen Ouyang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

40
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy DOI
Pan Liu, Zhengdong Zhang,

Huizhen Chen

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102182 - 102182

Published: Jan. 4, 2024

Language: Английский

Citations

15
Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches DOI Creative Commons
Kexin Cai,

Haoyue Jiang,

Yuanming Zou

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107281 - 107281

Published: June 26, 2024

Cardiovascular diseases (CVDs) have a complex pathogenesis and pose major threat to human health. Cardiomyocytes low regenerative capacity, their death is key factor in the morbidity mortality of many CVDs. Cardiomyocyte can be regulated by specific signaling pathways known as programmed cell (PCD), including apoptosis, necroptosis, autophagy, pyroptosis, ferroptosis, etc. Abnormalities PCD lead development variety cardiovascular diseases, there are also molecular-level interconnections between different under same disease model. Currently, link cardiomyocytes not fully understood. This review describes molecular mechanisms impact cardiomyocyte on development. Emphasis placed summary drugs potential therapeutic approaches that used treat targeting blocking cardiomyocytes.

Language: Английский

Citations

11
Role of pyroptosis in diabetic cardiomyopathy: an updated review DOI Creative Commons
Gan Wang, Tianyi Ma, Kang Huang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

Diabetic cardiomyopathy (DCM), one of the common complications diabetes, presents as a specific with anomalies in structure and function heart. With increasing prevalence DCM has high morbidity mortality worldwide. Recent studies have found that pyroptosis, programmed cell death accompanied by an inflammatory response, exacerbates growth genesis DCM. These provide theoretical basis for exploring potential treatment Therefore, this review aims to summarise possible mechanisms which pyroptosis promotes development well relevant targeting DCM, focusing on molecular NLRP3 inflammasome-mediated different cellular pathways associated effects occurring cells drugs inflammasome/pyroptosis This might fresh perspective foundation therapeutic agents

Language: Английский

Citations

9
Targeting Pyroptosis: A Novel Strategy of Ginseng for the Treatment of Diabetes and Its Chronic Complications DOI
Ke Li, Yajun Wang, Chen Chen

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156430 - 156430

Published: Jan. 1, 2025

Language: Английский

Citations

1
ROS-mediated ferroptosis and pyroptosis in cardiomyocytes: An update DOI
Tao Li, Ningning Wang, Dan Yi

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123565 - 123565

Published: March 1, 2025

Language: Английский

Citations

1
Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway DOI Creative Commons
Fan Li, Zhenfei Hu,

Yidan Huang

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2023, Volume and Issue: 18(1)

Published: July 10, 2023

Abstract Objective Dexmedetomidine (DEX) has been shown to have anti-apoptotic effects in diabetes mellitus, but its role mitigating diabetic cardiomyopathy (DCM) through ferroptosis regulation is unclear. Methods An vitro DCM model was established using H9C2 cells induced with high glucose (HG) and treated DEX at varying doses a nuclear factor erythroid 2-realated 2 (Nrf2) specific inhibitor ML385. Cell viability evaluated the MTT method after treatment or mannitol (MAN), dosage of used subsequent experimentation determined. The HG-induced osmotic pressure were assessed MAN as control. apoptosis flow cytometry. Protein levels Bcl2, Bax, Nrf2, glutathione peroxidase 4 (GPX4) measured Western blot. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) levels, Fe 2+ concentration reactive oxygen species (ROS) corresponding kits dichlorodihydrofluorescein diacetate, respectively. Results Treatment had no effect on cell viability. HG induction reduced viability, increased apoptosis, upregulated , MDA, ROS, downregulated Bcl2 protein SOD Nrf2 GPX4. inhibited promoted translocation, activated Nrf2/GPX4 pathway. Inhibition partially reversed protective against HG-evoked injury. Conclusion Our findings demonstrate that attenuates cardiomyocyte injury by inhibiting pathway, providing potential therapeutic targets for treatment.

Language: Английский

Citations

17
Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage DOI

Enzhuang Pan,

Huizhen Chen,

Xinyu Wu

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2023, Volume and Issue: 193, P. 105445 - 105445

Published: May 15, 2023

Language: Английский

Citations

15
IL‑37 suppresses macrophage ferroptosis to attenuate diabetic atherosclerosis via the NRF2 pathway DOI Open Access

Jinmei Xu,

Xu Han, Nan Xia

et al.

Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 25(6)

Published: May 3, 2023

IL-37 is a newly discovered inflammatory factor. However, the protective effect and underlying mechanisms of on atherosclerosis remain unclear. In present study, was used for intraperitoneal injection in diabetic ApoE-/- mice caused by streptozotocin. High glucose (HG)/ox-LDL to stimulate THP-1 original macrophage followed pretreatment vitro. The atheromatous plaque area, oxidative stress inflammation levels were evaluated, level ferroptosis detected vivo It identified that treatment significantly decreased area mice. not only improved blood lipid mice, but also reduced serum factors including IL-1β IL-18. Furthermore, increased GPX4 nuclear factor erythroid 2-related 2 (NRF2) aorta vitro experiment revealed inhibited HG/ox-LDL-induced macrophages, as evidenced cell membrane oxidation, malondialdehyde production expression. Moreover, it found enhanced translocation NRF2 while ML385, specific inhibitor, attenuated HG/ox-LDL. conclusion, suppressed attenuate progression via activating pathway.

Language: Английский

Citations

11
Role of Mitochondrial ROS for Calcium Alternans in Atrial Myocytes DOI Creative Commons
Yuriana Oropeza‐Almazán, Lothar A. Blatter

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 144 - 144

Published: Jan. 24, 2024

Atrial calcium transient (CaT) alternans is defined as beat-to-beat alternations in CaT amplitude and causally linked to atrial fibrillation (AF). Mitochondria play a significant role cardiac excitation–contraction coupling Ca signaling through redox environment regulation. In isolated rabbit myocytes, ROS production enhanced during alternans, measured by fluorescence microscopy. Exogenous (tert-butyl hydroperoxide) whereas scavengers (dithiothreitol, MnTBAP, quercetin, tempol) alleviated alternans. While the inhibition of cellular NADPH oxidases had no effect on interference with mitochondrial (ROSm) profound effects: (1) superoxide dismutase mimetic MitoTempo diminished shifted pacing threshold higher frequencies; (2) cyt c peroxidase SS-31, inhibitors ROSm complexes electron transport chain S1QEL1.1 S3QEL2, decreased severity alternans; however (3) impairment antioxidant defense nicotinamide nucleotide transhydrogenase NBD-Cl thioredoxin reductase-2 auranofin Our results suggest that intact provides crucial protection against pro-arrhythmic Thus, modulating state represents potential therapeutic approach for alternans-associated arrhythmias, including AF.

Language: Английский

Citations

4