Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
Language: Английский
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition in the innate immune system. Its overactivation leads to production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute development progression various diseases. In recent years, evidence has shown that gut microbiota plays an important role regulating activation NLRP3 inflammasome. Variations function composition can directly or indirectly influence inflammasome by influencing bacterial components metabolites. Additionally, exercise been effectively reduce while promoting beneficial changes microbiota. This suggests may play mediating effects on regulation. review explores impact activation, examines mechanisms through mediates anti-inflammatory exercise, providing new avenues for research.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16870 - 16870
Published: Nov. 28, 2023
Major depressive disorder (MDD) has a high prevalence and is major contributor to the global burden of disease. This psychiatric results from complex interaction between environmental genetic factors. In recent years, role gut microbiota in brain health received particular attention, compelling evidence shown that patients suffering depression have dysbiosis. Several studies reported dysbiosis-induced inflammation may cause and/or contribute development through dysregulation gut-brain axis. Indeed, as consequence dysbiosis, neuroinflammatory alterations caused by microglial activation together with impairments neuroplasticity symptoms. The modulation been recognized potential therapeutic strategy for management MMD. this regard, physical exercise positively change composition diversity, can underlie, at least part, its antidepressant effects. Given this, present review will explore relationship exercise, depression, an emphasis on non-invasive modulating and, regulating axis alleviating MDD-related
Language: Английский
Citations
20
Deleted Journal, Journal Year: 2024, Volume and Issue: 4
Published: Jan. 1, 2024
Abstract The brain controls the nerve system, allowing complex emotional and cognitive activities. microbiota–gut–brain axis is a bidirectional neural, hormonal, immune signaling pathway that could link gastrointestinal tract to brain. Over past few decades, gut microbiota has been demonstrated be an essential component of plays crucial role in regulating most functions various body organs. effects on occur through production neurotransmitters, hormones, metabolites, regulation host-produced or synthesis metabolites by themselves. This affects host's behavior, mood, attention state, brain's food reward system. Meanwhile, there intimate association between exercise. Exercise can change numerically qualitatively, which may partially responsible for widespread benefits regular physical activity human health. Functional magnetic resonance imaging (fMRI) non-invasive method show areas enabling delineation specific regions involved neurocognitive disorders. Through combining exercise tasks fMRI techniques, researchers observe higher functions. However, exercise's health via have little studied. article reviews highlights connections these three interactions, will help us further understand positive provide new strategies approaches prevention treatment diseases.
Language: Английский
Citations
7
Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e25186 - e25186
Published: Feb. 1, 2024
The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of on inducing formation vulnerable atherosclerotic plaque, discuss effect intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) plaque stability. Finally, include impact stability, propose a new therapeutic direction for coronary heart disease. Gut regulation intervenes progress arteriosclerosis, especially atherosclerosis, by avoiding or reducing lower morbidity rate myocardial infarction.
Language: Английский
Citations
6
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Feb. 21, 2024
Intracerebral hemorrhagic stroke, characterized by acute hemorrhage in the brain, has a significant clinical prevalence and poses substantial threat to individuals’ well-being productivity. Recent research elucidated role of gut microorganisms their metabolites influencing brain function through microbiota-gut-brain axis (MGBA). This article provides comprehensive review current literature on common metabolites, short-chain fatty acids (SCFAs) trimethylamine-N-oxide (TMAO), produced microbiota. These have demonstrated potential traverse blood–brain barrier (BBB) directly impact tissue. Additionally, these compounds modulate parasympathetic nervous system, thereby facilitating release pertinent substances, impeding buildup inflammatory agents within manifesting anti-inflammatory properties. Furthermore, this scholarly analysis delves into existing dearth investigations concerning influence cerebral functions, while also highlighting prospective avenues for future research.
Language: Английский
Citations
4
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 103, P. 102585 - 102585
Published: Nov. 23, 2024
The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer longevity. Herein, we comprehensively review benefits microbial rejuvenation - FMT promote aging, with few studies documenting life length properties. This explores how preconditioning donors standard lifestyle pharmacological antiaging interventions reshape microbiome, resulting being also FMT-transferable. Finally, expose current clinical uses context therapy address challenges regulatory landscape, protocol standardization, health risks that require refinement effectively utilize elderly.
Language: Английский
Citations
4
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 115 - 115
Published: Feb. 11, 2025
Cholesterol is an essential element for the development and normal function of central nervous system. While peripheral cholesterol influenced by liver metabolism diet, brain takes place in isolated system due to impermeability blood–brain barrier (BBB). However, cross-talk occurs between periphery, specifically through metabolites such as oxysterols that play key roles regulating balance. Several neurodegenerative conditions Alzheimer’s disease or Parkinson’s are considered be affected loss this Also, treatment hypercholesterolemia needs consider these discrete interferences possible implications each therapeutic approach. This particularly important because 27-hydroxycholesterol 24-hydroxycholesterol, which can cross BBB involved metabolism. paper examines metabolic pathways periphery focuses on complex metabolisms. we emphasize regulatory role need integrated approach management.
Language: Английский
Citations
0
Spinal Cord Series and Cases, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 25, 2025
Language: Английский
Citations
0
PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17185 - e17185
Published: April 4, 2024
Background Cardiovascular diseases are the leading cause of death worldwide, significantly impacting public health. Atherosclerotic cardiovascular account for majority these deaths, with atherosclerosis marking initial and most critical phase their pathophysiological progression. There is a complex relationship between atherosclerosis, gut microbiome’s composition function, potential mediating role exercise. The adaptability microbiome feasibility exercise interventions present novel opportunities therapeutic preventative approaches. Methodology We conducted comprehensive literature review using professional databases such as PubMed Web Science. This focuses on application meta-omics techniques, particularly metagenomics metabolomics, in studying effects atherosclerosis. Results Meta-omics technologies offer unparalleled capabilities to explore intricate connections exercise, microbiome, metabolome, cardiometabolic highlights advancements applications research, examines how influences microbiome. delve into mechanisms connecting elements from metabolic perspective. Metagenomics provides insight changes microbial strains post-exercise, while metabolomics sheds light shifts metabolites. Together, approaches understanding impacts through specific mechanisms. Conclusions Exercise serving intermediary. technology holds substantial promise investigating microbiome; however, its methodologies require further refinement. Additionally, there pressing need more extensive cohort studies enhance our comprehension connection among element.
Language: Английский
Citations
3
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: Dec. 1, 2023
This study delves into the impact of yeast culture (YC) on rumen epithelial development, microbiota, and metabolome, with aim investigating YC's mechanism in regulating fermentation. Thirty male lambs Hu sheep similar age body weight were selected randomly divided three groups 10 each group. Lambs fed a total mixed ration [TMR; rough: concentrate (R:C) ratio ≈ 30:70] to meet their nutritional needs. The experiment adopted completely randomized design (CRD). control group (CON) was basal diet high concentrate, which 20 g/d YC added low dose (LYC) 40 (HYC). pretrial period 14 days, experimental trial 60 days. At end 60-day trial, ruminal tissues collected for histomorphological analysis, microorganisms analyzed by 16S rDNA sequencing metabolites untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics techniques. results showed that improved papilla development increased length (p < 0.05), while decreased cuticle thickness 0.05). reduced relative abundance Prevotella_1 significantly Ruminococcaceae_UCG-005, uncultured_bacterium_f_Lachnospiraceae, Ruminococcus_1 genus Metabolomics analysis changed related amino acid metabolism, lipid metabolism vitamin pathways rumen. In summary, might maintain health under high-concentrate conditions changing microbiota structure fermentation patterns, thereby affecting metabolic profiles repairing injury.
Language: Английский
Citations
9