Targeting Intrinsic and Extrinsic Pathways of Ferroptosis: A Novel Anticancer Strategy of Curcumin DOI Creative Commons
Wei Hao, Yuan Gao, Bangwei Cao

et al.

Pharmacognosy Magazine, Journal Year: 2024, Volume and Issue: 20(4), P. 1061 - 1070

Published: May 19, 2024

Background The turmeric rhizome yields a medicinal compound called curcumin. Curcumin’s anticancer methods mostly involve blocking cell invasion and proliferation, controlling gene expression, preventing angiogenesis, triggering apoptosis, inducing ferroptosis. A brand-new nonapoptotic kind of planned death is Ferroptosis can be initiated through two major pathways: the extrinsic or transporter-dependent pathway, intrinsic enzyme-regulated pathway. It unknown, therefore, how curcumin its derivatives prevent cancer by Purpose Through this review, we concentrate on possible mechanisms means effect ferroptosis; regulation iron metabolism, synthesis reactive oxygen species, targeting antioxidant pathways represent few these processes. Methodology Retrieve English literature in treatment tumor ferroptosis from databases such as Web Science, etc. Conclusion This review provides rationale for clinical use agents.

Language: Английский

The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

et al.

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

Citations

64
Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges DOI
Wei Wang, Mingqin Li, Lingzhi Wang

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 570, P. 216332 - 216332

Published: Aug. 1, 2023

Language: Английский

Citations

53
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis DOI

Tianqi Ming,

Jiarong Lei,

Yu‐Hui Peng

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3954 - 3972

Published: June 4, 2024

Driven by iron-dependent lipid peroxidation, ferroptosis is regulated p53 and solute carrier family 7 member 11 (SLC7A11)/glutathione/glutathione peroxidase 4 (GPX4) axis in colorectal cancer (CRC). This study aimed to investigate the influence of curcumin (CUR) on CRC. The efficacies CUR malignant phenotype CRC cells were determined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, wound healing, clonogenic assays. effects evaluated transmission electron microscopy, lactate dehydrogenase release assay, Fe

Language: Английский

Citations

28
Curcumin Induces Autophagy-mediated Ferroptosis by Targeting the PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer DOI Creative Commons
Xin Zheng, Jun Liu, Wei Hu

et al.

The Turkish Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 35(8), P. 625 - 633

Published: April 8, 2025

As a very common malignancy of the digestive system, incidence and mortality rates gastric cancer (GC) are increasing year by year. The critical role ferroptosis in development has been well-documented. polyphenol compound curcumin shows prominent anti-tumor effects multiple types, including GC. However, whether participates GC tumorigenesis regulating remains unknown. Gastric cells AGS HGC-27 were treated with (0, 10, 20 μM). Cell viability death evaluated through CCK-8 LDH release assays. LC3B expression was estimated immunofluorescence staining. Intracellular ferrous iron (Fe2+), GSH, MDA, lipid ROS levels assessed corresponding assay kits. cellular autophagy markers (ATG5, ATG7, Beclin 1, LC3B), (ACSL4, SLC7A11, GPX4), phosphorylated (p)-PI3K, p-AKT, p-mTOR determined western blotting. Curcumin attenuated cell but stimulated cells. enhanced cells, as demonstrated increased ATG5, LC3B. Besides, upregulated iron, ACSL4 while downregulated ROS, GPX4 levels, suggesting its stimulation on decreased p-PI3K, Importantly, inhibitor ferrostatin-1 overturned impacts viability, death, ferroptosis. suppresses inducing autophagy-mediated inactivating PI3K/AKT/mTOR signaling.

Language: Английский

Citations

8
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy DOI
Yiping Zhang, Xie Jun

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(4), P. 2041 - 2076

Published: Feb. 23, 2024

Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.

Language: Английский

Citations

6
Ferroptosis and mitochondrial dysfunction in acute central nervous system injury DOI Creative Commons
Wenxue Dong,

Fanghe Gong,

Yu Zhao

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 9, 2023

Acute central nervous system injuries (ACNSI), encompassing traumatic brain injury (TBI), non-traumatic like stroke and encephalomeningitis, as well spinal cord injuries, are linked to significant rates of disability mortality globally. Nevertheless, effective feasible treatment plans still be formulated. There primary secondary occurred after ACNSI. Most ACNSIs exhibit comparable which offer numerous potential therapeutic targets for enhancing clinical outcomes. Ferroptosis, a newly discovered form cell death, is characterized lipid peroxidation process that dependent on iron oxidative conditions, also indispensable mitochondria. Ferroptosis play vital role in many neuropathological pathways, may induce mitochondrial dysfunction, thereby indicating the essentiality connection ferroptosis ACNSIs. there remains lack clarity regarding involvement mitochondria occurrence In recent studies, anti-ferroptosis agents such inhibitor Ferrostain-1 chelation therapy have shown ameliorating deleterious effects cases The importance this evidence extremely relation research control Therefore, our review aims provide researchers focusing outcomes with valuable insights by summarizing physiopathological mechanisms exploring correlation between ferroptosis,

Language: Английский

Citations

16
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI Creative Commons
Nemanja Živanović, Marija Lesjak, Nataša Simin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334

Published: March 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Language: Английский

Citations

6
Ce6-modified Fe ions-doped carbon dots as multifunctional nanoplatform for ferroptosis and photodynamic synergistic therapy of melanoma DOI Creative Commons
Haiqiu Li,

Yichen Dou,

Hang Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 10, 2024

Abstract Background Despite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), lack efficient inducers poor solubility photosensitizers restrict their synergistic strategies. With unique advantages, carbon dots (CDs) are expected to serve as innovative building blocks for combination cancers. Results Herein, an ferroptosis/PDT integrated nanoplatform is constructed based on chlorin e6-modified Fe ions-doped (Fe-CDs@Ce6). As a novel type iron-carbon hybrid nanoparticles, as-prepared Fe-CDs can selectively activate ferroptosis, prevent angiogenesis inhibit migration mouse skin cells (B16), but have no toxicity normal cells. The nano-conjugated structures facilitate not only aqueous dispersibility Ce6, also self-accumulation ability Fe-CDs@Ce6 within area without requiring extra targets. Moreover, therapeutic effects synergistically enhanced due increased GSH depletion by PDT elevated singlet oxygen ( 1 O 2 ) production efficiency Fe-CDs. When combined with laser irradiation, tumor growth be significantly suppressed through cyclic administration. T -weighted magnetic resonance imaging (MRI) capability reveals potentials cancer diagnosis navigation therapy. Conclusions Our findings indicate multifunctionality in effectively combining therapy, targeting MRI imaging, which enables become promising biocompatible treatment melanoma. Graphic

Language: Английский

Citations

5
Ferroptosis: a new mechanism of traditional Chinese medicine for cancer treatment DOI Creative Commons
Jiahao Zhu,

Peipei Shen,

Yu Xu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 16, 2024

Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the build-up of lipid peroxidation and reactive oxygen species (ROS) derived lipids within cells. Recent studies demonstrated efficacy ferroptosis inducers in targeting malignant cells, thereby establishing promising avenue for combating cancer. Traditional Chinese medicine (TCM) has long history use widely used cancer treatment. TCM takes holistic approach, viewing patient as system utilizing herbal formulas to address complex diseases such have elucidated molecular mechanisms underlying induction during These identified numerous plant metabolites derivatives that target multiple pathways targets. can induce tumor cells through various regulatory mechanisms, amino acid, iron, metabolism pathways, which may provide therapeutic strategies apoptosis-resistant also influence anticancer immunotherapy via ferroptosis. This review comprehensively elucidates ferroptosis, highlights pivotal genes involved orchestrating this process, evaluates advancements made research pertaining provides theoretical insights into tumors using botanical drugs.

Language: Английский

Citations

4