Molecules,
Journal Year:
2023,
Volume and Issue:
28(24), P. 8090 - 8090
Published: Dec. 14, 2023
Doxorubicin
(DOX),
an
anthracycline-based
chemotherapeutic
agent,
is
widely
used
to
treat
various
types
of
cancer;
however,
prolonged
treatment
induces
cardiomyotoxicity.
Although
studies
have
been
performed
overcome
DOX-induced
cardiotoxicity
(DICT),
no
effective
method
currently
available.
This
study
investigated
the
effects
and
potential
mechanisms
Poncirus
trifoliata
aqueous
extract
(PTA)
in
DICT.
Changes
cell
survival
were
assessed
H9c2
rat
cardiomyocytes
MDA-MB-231
human
breast
cancer
cells.
The
C57BL/6
mice
treated
with
DOX
induce
DICT
vivo,
alterations
electrophysiological
characteristics,
serum
biomarkers,
histological
features
examined.
PTA
inhibited
decrease
viability
but
did
not
affect
viability.
Additionally,
restored
abnormal
heart
rate,
R-R
interval,
QT
ST
segment
cardiac
hepatic
toxicity
indicators
model.
Moreover,
administration
protected
against
myocardial
fibrosis
apoptosis
tissue
expression
NAD(P)H
dehydrogenase
quinone
acceptor
oxidoreductase
1
a
concentration-dependent
manner.
In
conclusion,
inhibitory
effect
on
attributable
its
antioxidant
properties,
suggesting
as
phytotherapeutic
agent
for
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
162, P. 114591 - 114591
Published: March 23, 2023
Melatonin
confers
cardioprotective
effects
on
multiple
cardiovascular
diseases,
including
doxorubicin-induced
cardiomyopathy.
The
effectiveness
of
melatonin
in
mitigating
myocardial
injuries
caused
by
Doxorubicin
through
enhancement
mitochondrial
function
is
already
established,
however,
the
role
regulating
Sirtuin-1
(Sirt1)/Nuclear
factor
E2-associated
2
(Nrf2)
pathway
lessening
onset
Doxorubicin-induced
cardiomyopathy
yet
to
be
elucidated.
To
address
this,
H9C2
cardiomyocytes
and
C57BL/6
mice
were
employed
construct
vitro
vivo
models
Dox-induced
impairments,
respectively.
Results
showed
that
Dox
markedly
evoked
oxidative
stress,
pyroptosis
apoptosis
both
vivo,
which
significantly
alleviated
administration.
Mechanistically,
attenuated
downregulation
Sirt1
Nrf2,
inhibition
Nrf2
reversed
melatonin.
In
conclusion,
our
studies
suggest
activation
Sirt1/Nrf2
underlying
mechanism
behind
melatonin's
ability
curtail
pyroptosis,
These
promising
results
demonstrated
potential
application
as
a
treatment
for
cardiac
injury.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 680 - 680
Published: Feb. 6, 2024
In
recent
years,
the
emergence
of
cancer
drug
resistance
has
been
one
crucial
tumor
hallmarks
that
are
supported
by
level
genetic
heterogeneity
and
complexities
at
cellular
levels.
Oxidative
stress,
immune
evasion,
metabolic
reprogramming,
overexpression
ABC
transporters,
stemness
among
several
key
contributing
molecular
response
mechanisms.
Topo-active
drugs,
e.g.,
doxorubicin
topotecan,
clinically
active
utilized
extensively
against
a
wide
variety
human
tumors
often
result
in
development
failure
to
therapy.
Thus,
there
is
an
urgent
need
for
incremental
comprehensive
understanding
mechanisms
specifically
context
topo-active
drugs.
This
review
delves
into
intricate
mechanistic
aspects
these
intracellular
extracellular
explores
use
potential
combinatorial
approaches
utilizing
various
drugs
inhibitors
pathways
involved
resistance.
We
believe
this
will
help
guide
basic
scientists,
pre-clinicians,
clinicians,
policymakers
toward
holistic
interdisciplinary
strategies
transcend
resistance,
renewing
optimism
ongoing
battle
cancer.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116004 - 116004
Published: Dec. 11, 2023
Dysregulation
of
mitochondrial
homeostasis
is
common
to
all
types
cardiovascular
diseases.
SIRT3
regulates
apoptosis
and
autophagy,
material
energy
metabolism,
oxidative
stress,
inflammation,
fibrosis.
As
an
important
mediator
node
in
the
network
mechanisms,
essential
many
activities.
This
review
explains
how
tricarboxylic
acid
cycle
treat
A
novel
description
impact
lifestyle
factors
on
expression
from
angles
nutrition,
exercise,
temperature
provided.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9692 - 9692
Published: Sept. 7, 2024
Doxorubicin
(DOX)
is
a
potent
chemotherapeutic
agent
with
well-documented
dose-dependent
cardiotoxicity.
Regular
exercise
recognized
for
its
cardioprotective
effects
against
DOX-induced
cardiac
inflammation,
although
the
precise
mechanisms
remain
incompletely
understood.
The
activation
of
inflammasomes
has
been
implicated
in
pathogenesis
and
treatment
cardiotoxicity,
nucleotide-binding
domain-like
receptor
protein
3
(NLRP3)
inflammasome
emerging
as
key
mediator
cardiovascular
inflammation.
This
study
aimed
to
investigate
role
modulating
NLRP3
protect
Male
Sprague–Dawley
rats
were
randomly
assigned
receive
10-day
course
DOX
or
saline
injections,
without
preceding
10-week
treadmill
running
regimen.
Cardiovascular
function
histological
changes
subsequently
evaluated.
cardiotoxicity
was
characterized
by
atrophy,
systolic
dysfunction,
hypotension,
alongside
inflammasome.
Our
findings
revealed
that
regular
preserved
mass
hypertrophic
indices
prevented
it
did
not
fully
preserve
blood
pressure.
These
results
underscore
significant
While
entirely
prevent
our
demonstrate
confers
protection
suppressing
heart,
underscoring
anti-inflammatory
role.
Further
research
should
explore
temporal
dynamics
interactions
among
exercise,
pyroptosis,
other
pathways
enhance
translational
applications
medicine.
Journal of Ginseng Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Ginsenosides
have
notable
bioactivity
in
treating
cardiovascular
diseases,
but
the
mechanisms
of
their
combined
use
with
Peroxiredoxin
6
(PRDX6)
myocardial
injury
remain
unclear.
This
study
explores
synergistic
effects
Ginsenoside
Rb1
(Gs-Rb1)
and
PRDX6,
aiming
to
provide
a
theoretical
foundation
for
therapeutic
potential.
We
established
rat
model
isoproterenol
(ISO)-induced
observed
that
combination
therapy
was
more
effective
than
single-drug
treatments,
as
shown
by
ECG
monitoring
Masson
staining.
performed
RNA
sequencing
(RNA-Seq)
on
group
ISO
group.
The
results
indicated
that,
compared
group,
alleviated
reducing
inflammation,
oxidative
stress,
apoptosis.
Further
analyses,
including
cell
morphology,
apoptosis
rates,
HE
staining,
ROS
fluorescence
intensity,
inflammation-related
proteins,
confirmed
successfully
inhibited
apoptosis,
managed
lessened
inflammation.
Combined
treatment
Gs-Rb1
PRDX6
significantly
cardiac
tissue
fibrosis
rats,
leading
marked
decrease
serum
CK
LDH
levels.
RNA-seq
analysis
revealed
upregulated
genes
related
lipid
metabolism
small
molecule
biosynthesis,
while
downregulated
were
associated
Validation
experiments
treatment's
significant
inhibition
activity,
These
support
effectiveness
two-drug
suppressing
key
biological
processes
tissue,
suggesting
potential
combating
fibrosis.
clarifies
how
work
together
protect
against
damage,
demonstrating
reduces
stress.
highlights
new
avenue
developing
ginseng-based
treatments.
In
recent
years,
the
emergence
of
cancer
drug
resistance
is
one
crucial
tumor
hallmarks
which
supported
by
level
genetic
heterogeneity
and
complexities
at
cellular
levels.
Oxidative
stress,
immune
evasion,
metabolic
reprogramming,
overexpression
ABC
transporters
stemness
are
among
several
key
contributing
molecular
response
mechanisms.
Topo-active
drugs,
e.g.,
doxorubicin
topotecan,
clinically
active
utilized
extensively
against
a
wide
variety
human
tumors
often
results
in
development
failure
to
therapy.
Thus,
there
an
urgent
need
for
incremental
comprehensive
understanding
mechanisms
specifically
context
topo-active
drugs.
This
review
delves
into
intricate
mechanistic
aspects
these
intracellular
extracellular
explores
use
potential
combinatorial
approaches
utilizing
various
drugs
inhibitors
pathways
involved
resistance.
We
believe
that
this
will
help
guide
basic
scientists,
pre-clinicians,
clinicians,
policymakers
toward
holistic
interdisciplinary
strategies
transcend
resistance,
renewing
optimism
ongoing
battle
cancer.
