MOLECULAR FEATURES OF THE ACTION OF HORMONES ON ANGIOGENESIS DOI
E. A. Teplyashina, N. A. Malinovskaya

Problems of Biological Medical and Pharmaceutical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 62 - 72

Published: Dec. 20, 2024

The review presents data on the symbiotic relationship between nervous and vascular systems, active interaction which reflects main problems of development serious neurological disorders. purpose article is to establish more detailed understanding mechanisms action hormones local microenvironment endothelial cells under conditions angiogenesis, as well identify latest molecular in pathological conditions. literature was studied, including scientific domestic foreign publications that were prepared mainly over last five years. research methodology content analysis primary sources results obtained by other authors. use taxonomic comparative made it possible study compare types effects depending place their synthesis. systemic-structural method ensured construction a diagram reflecting influence hormonal molecules angiogenesis. both Russian provides an basic factors system. At same time, mature network basis cellular metabolism. There clear coordination processes such proliferation, differentiation, migration, matrix adhesion intercellular signaling processes. Vascular growth complex dynamic process, regulated pro- antiangiogenic factors, molecules, enzymes, transcription hormones. Hormones angiogenesis either directly, acting cells, or indirectly, regulating proangiogenic factors. This important information, since one key for invasion metastasis tumor cells. Therefore, treatment promising antitumor strategy aimed at optimization. conclusion formulated about need develop effective specific biomarkers respond damaged angiogenic system, with view practical application fundamental field neurobiology.

Language: Английский

Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs DOI Creative Commons

Anil Kumar Grewal,

Raj Kumar Salar

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100040 - 100040

Published: June 27, 2024

Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.

Language: Английский

Citations

23
Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma DOI Open Access
Md. Ataur Rahman,

Meser M. Ali

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975

Published: Aug. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Language: Английский

Citations

11
Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy DOI Creative Commons
Şeyma Işık, Mukaddes Özçeşmeci, Ayfer Kalkan Burat

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 20, 2025

In this study, the in vitro photodynamic therapy (PDT) activity of two zinc phthalocyanines (ZnPc1 and ZnPc2) was systematically examined human umbilical vein endothelial cells, focusing on PDT-induced cytotoxicity, reactive oxygen species (ROS) generation, inhibition angiogenic processes. Both ZnPcs demonstrated minimal cytotoxicity absence light, confirming their safety as photosensitizers. ZnPc-PDT led to significant cell death via apoptosis. ZnPc1 exhibited enhanced ROS particularly at elevated concentrations. Furthermore, ZnPc1-mediated PDT showed more pronounced migration, invasion, capillary-like tube formation than ZnPc2. Wound-healing assays revealed a substantial delay (HUVEC) migration following ZnPc1-PDT, which also displayed VEGF-induced directional invasion. Endothelial effectively disrupted by even lower concentrations, compared Collectively, these findings highlight superior cytotoxic anti-angiogenic properties with ZnPc2, highlighting its potential highly effective photosensitizer for therapy. The ability simultaneously target tumor cells disrupt angiogenesis establishes it potent candidate integrated cancer therapies that combine both antitumor antiangiogenic strategies, offering approach combat progression.

Language: Английский

Citations

1
The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention DOI
Adriana Albini, Douglas M. Noonan, Paola Corradino

et al.

Cancer Prevention Research, Journal Year: 2024, Volume and Issue: 17(7), P. 289 - 303

Published: May 7, 2024

Abstract Cancer growth is dependent on angiogenesis, the formation of new blood vessels, which represents a hallmark cancer. After this concept was established in 1970s, inhibition tumor development and metastases by blocking neoangiogenic process has been an important approach to treatment tumors. However, antiangiogenic therapies are often administered when cancer already progressed. The key reducing burden prevention. We noticed 20 years ago that series possible chemopreventive agents showed properties tested experimental models. This article reviews relevant advances understanding rationale for targeting angiogenesis therapy, prevention, interception recently investigated substances with activity may be suitable such strategies. Many compounds, either dietary derivatives or repurposed drugs, tools angioprevention. Such molecules have favorable safety profile likely allow prolonged duration necessary efficient preventive strategy. Recent evidence mechanisms use described here food derivatives, including flavonoids, retinoids, triterpenoids, omega fatty acids, carotenoids from marine microorganisms. As examples, number epigallocatechin, resveratrol, xanthohumol, hydroxytyrosol, curcumin, fenretinide, lycopene, fucoxanthin, as aspirin, β blockers, renin–angiotensin–aldosterone inhibitors, carnitines, biguanides, reviewed.

Language: Английский

Citations

6
Extracellular Vesicles in Breast Cancer: From Intercellular Communication to Therapeutic Opportunities DOI Creative Commons
Muttiah Barathan, Sook Luan Ng, Yogeswaran Lokanathan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 654 - 654

Published: May 14, 2024

Breast cancer, a multifaceted and heterogeneous disease, poses significant challenges in terms of understanding its intricate resistance mechanisms devising effective therapeutic strategies. This review provides comprehensive overview the landscape extracellular vesicles (EVs) context breast highlighting their diverse subtypes, biogenesis, roles intercellular communication within tumour microenvironment (TME). The discussion spans various aspects, from EVs stromal cells cancer to influence on angiogenesis, immune response, chemoresistance. impact EV production different culture systems, including two dimensional (2D), three (3D), organoid models, is explored. Furthermore, this delves into potential presenting emerging strategies such as engineered for gene delivery, nanoplatforms targeted chemotherapy, disrupting derived treatment approach. Understanding these complex interactions milieu crucial identifying developing new targets.

Language: Английский

Citations

5
Antineoplastic effects of icaritin: molecular mechanisms and applications DOI Creative Commons
Piao Luo, Liyang Zhang,

Guangqing Cheng

et al.

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(2)

Published: Jan. 1, 2025

Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval ICA softgel capsules as class 1.2 traditional Chinese medicine (TCM) innovative drug represents major advancement offering novel therapeutic approach for patients with advanced hepatocellular carcinoma (HCC). Class TCM drugs generally denote extracts and formulations derived single plants, animals, minerals, or other substances. exhibits diverse pharmacological effects, encompassing anti-inflammatory, immune-regulatory, anti-oxidation, anti-osteoporosis, anti-depression, notably anti-cancer properties. This review presents comprehensive overview molecular mechanisms underlying properties ICA, further highlights recent progress in use cancer research, discusses present challenges, examines potential opportunities application development.

Language: Английский

Citations

0
Recombinant Human Endostatin Suppressed the Biological Behavior of Human Umbilical Vein Endothelial Cells Under Hypoxic and Hypoxic/Starvation Conditions In Vitro DOI Creative Commons

Yongsheng Jia,

Cuicui Zhang, Jimin Zhao

et al.

Analytical Cellular Pathology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exosomes, autophagy, and cancer: A complex triad DOI Creative Commons

María Guerra‐Andrés,

Álvaro F. Fernández, Tania Fontanil

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Cancer remains one of the leading causes death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, incidence certain types cancer persists, urging identification clinically relevant biomarkers development novel therapeutic strategies to improve clinical outcomes overcome treatment resistance. Exosomes, small extracellular vesicles released by diverse cells, have attracted interest biomedical research due their potential as carriers for different treatments. Moreover, exosomes play a pivotal role intercellular communication, modulating various cellular processes. One those is autophagy, pro‐survival pathway that essential human cells. Even though autophagy traditionally described catabolic route, its machinery intricately involved responses, including vesicle formation secretion. In this regard, link between complex, bidirectional, highly dependent on context. Interestingly, both processes been extensively implicated pathogenesis, highlighting targets. This review updates our understanding how can participate progression, with specific focus influence tumor growth, angiogenesis, metastasis. Additionally, interplay these minutely reviewed discussed, we hypothesize crosstalk may hold valuable clues biomarker discovery strategies.

Language: Английский

Citations

0
Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy DOI Creative Commons

Pratibha Pandey,

Sorabh Lakhanpal, Ashok Kumar Bishoyi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Cancer is a deadly disease and one of the primary causes mortality worldwide. therapy presents significant challenges, such as chemotherapy resistance, high toxicity, recurrence, metastasis. As result, development novel therapeutic agents for cancer continues to be top goal expand number efficient treatments available. The advent nanotechnology an important turning point in several scientific disciplines. Owing increasing difficulty this problem, researchers have begun focus their attention on possibility employing plants or extracts from potential tumor treatment. More than 3,000 medicinal plant species been documented worldwide utilization Nevertheless, crude lack specificity, dosages are not clearly specified. To enhance efficacy these natural substances, used them conjunction with silver nanoparticles (AgNPs). Plants possess intricate phytochemical components including sugars, polyphenols, amino acids, flavonoids, terpenoids, alkaloids, proteins, which can function reducing stabilizing agents. In recent years, application plant-derived AgNPs has increased significantly, particularly These green-synthesized regarded outstanding tools detection targeted drug delivery at site. By leveraging distinctive characteristics antioxidant anticancer qualities plants, selectively eradicate cells while sparing normal healthy cells. This comprehensive review aimed summarize key aspects agents, biosynthesis AgNPs, advancements antitumor AgNPs.

Language: Английский

Citations

0