Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Aug. 12, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 597 - 597
Published: Jan. 2, 2024
Hepatocellular carcinoma (HCC) presents a significant global health threat, particularly in regions endemic to hepatitis B and C viruses, because of the ongoing pandemic obesity causing metabolic-dysfunction-related fatty liver disease (MAFLD), precursor HCC. The molecular intricacies HCC, genetic epigenetic alterations, dysregulated signaling pathways facilitate personalized treatment strategies based on profiling. Epigenetic regulation, encompassing DNA methyltion, histone modifications, noncoding RNAs, functions as critical layer influencing HCC development. Long RNAs (lncRNAs) are spotlighted for their diverse roles gene regulation potential diagnostic therapeutic tools cancer. In this review, we explore pivotal role lncRNAs including MAFLD viral hepatitis, most prevalent risk factors hepatocarcinogenesis. dysregulation is implicated progression by modulating chromatin transcription, sponging miRNAs, structural functions. studies contribute deeper comprehension pathogenesis offer promising routes precision medicine, highlighting utility early biomarkers, prognostic indicators, targets.
Language: Английский
Citations
19
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 26, 2025
Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these in alternative splicing-driven tumor progression have rarely been studied. Here, we show novel protein TPM3P9, encoded by lncRNA tropomyosin 3 pseudogene 9, exhibits activity clear cell renal carcinoma (ccRCC) enhancing RNA splicing. Overexpression TPM3P9 promotes proliferation growth. Mechanistically, binds to RRM1 domain splicing factor RBM4 inhibit RBM4-mediated exon skipping transcription TCF7L2. This results increased expression splice variant TCF7L2-L, which activates NF-κB signaling via its interaction SAM68 transcriptionally induce RELB expression. From a clinical perspective, is upregulated cancer tissues significantly correlated TCF7L2-L RELB. High or low associated poor survival patients ccRCC. Collectively, our findings functionally clinically characterize "noncoding RNA"-derived microprotein thus identify potential prognostic therapeutic factors cancer.
Language: Английский
Citations
2
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: April 15, 2024
Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies revealed ncRNA-derived micropeptides exhibit regulatory functions in the development many tumours. Although some these inhibit tumour growth, others promote it. Understanding role ncRNA-encoded cancer poses new challenges for research, but also offers promising prospects therapy. In this review, we summarize types ncRNAs encode highlighting technical developments made it easier research such as ribosome analysis, mass spectrometry, bioinformatics methods, and CRISPR/Cas9. based on distribution different subcellular locations, explain biological human cancers discuss their underestimated potential diagnostic biomarkers anticancer therapeutic targets clinical applications, information may contribute discovery micropeptide-based tools early diagnosis drug development.
Language: Английский
Citations
11
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Feb. 12, 2025
The significance of m6A modifications in several biological processes has been increasingly recognized, particularly the context cancer. For instance, gastric cancer (GC) have significantly implicated tumor progression, metastasis, and treatment resistance. GC is characterized by differential expression regulators. High writers such as METTL3 WTAP are associated with poor prognosis aggressive clinical features. Conversely, low METTL14 linked to worse outcomes, whereas elevated levels demethylases, FTO ALKBH5, correlate better survival rates. These regulators influence cellular functions, including proliferation, invasion, migration, glycolysis, chemotherapy resistance, thereby affecting growth therapeutic outcomes. assessment modification patterns profiles m6A-related genes hold substantial potential for improving diagnosis GC. In this review, we provide an updated comprehensive summary role GC, emphasizing their molecular mechanisms, significance, translational applications developing novel diagnostic strategies.
Language: Английский
Citations
1
Cellular Signalling, Journal Year: 2024, Volume and Issue: 117, P. 111076 - 111076
Published: Feb. 2, 2024
Language: Английский
Citations
6
Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(10), P. 2105 - 2119
Published: May 27, 2024
Abstract Non-alcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern associated with high risk of metabolic syndrome, and impacted substantial segment the population. The spectrum ranges from simple to non-alcoholic steatohepatitis (NASH), which can progress cirrhosis hepatocellular carcinoma (HCC) is increasingly becoming prevalent indication for transplantation. existing therapeutic options NAFLD, NASH, HCC are limited, underscoring urgent need innovative treatment strategies. Insights into gene expression, particularly RNA modifications such N 6 methyladenosine (m A), hold promising avenues interventions. These play integral roles in metabolism cellular functions, encompassing entire NAFLD-NASH-HCC progression. This review will encompass recent insights on diverse modifications, including m A, pseudouridine (ψ), 1 -methyladenosine 5-methylcytidine 5 C) across various species. It uncover their significance crucial aspects steatosis, inflammation, fibrosis, tumorigenesis. Furthermore, prospective research directions implications be explored, advancing our comprehensive understanding intricate interconnected nature these pathological conditions.
Language: Английский
Citations
5
Cells, Journal Year: 2023, Volume and Issue: 12(18), P. 2272 - 2272
Published: Sept. 14, 2023
With recent advancements in biological research, long non-coding RNAs (lncRNAs) with lengths exceeding 200 nucleotides have emerged as pivotal regulators of gene expression and cellular phenotypic modulation. Despite initial skepticism due to their low sequence conservation levels, significance various processes has become increasingly apparent. We provided an overview lncRNAs discussed defining features modes operation. then explored crucial function the hepatocarcinogenesis process, elucidating complex involvement hepatocellular carcinoma (HCC). The influential role within HCC tumor microenvironment is emphasized, illustrating potential key modulators disease dynamics. also investigated significant influence N6-methyladenosine (m6A) modification on lncRNA HCC, enhancing our understanding both roles upstream regulators. Additionally, promising biomarkers was liver cancer diagnosis, suggesting a novel avenue for future research clinical application. Finally, work underscored dual contributors pathogenesis innovative tools its diagnosis. Existing challenges prospective trajectories are discussed, emphasizing advancing research.
Language: Английский
Citations
11
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 231 - 241
Published: Oct. 30, 2024
Language: Английский
Citations
4
Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 140 - 140
Published: Jan. 24, 2025
Amidst the prevalent and notable characteristic of a hypoxic microenvironment present in majority solid tumors, burgeoning number studies have revealed significance noncoding RNAs (ncRNAs) tumor regions. The transcriptome cancers is highly heterogeneous, with transcripts playing crucial roles. Long (lncRNAs) circular (circRNAs) are two distinctive classes ncRNA that garnering increasing attention. Biologically, they possess intriguing properties significant regulatory functions. Clinically, as promising biomarkers therapeutic targets. Additionally, recent research has evaluated clinical applications these ncRNAs RNA-based treatments noninvasive liquid biopsies. This review provides comprehensive summary on lncRNAs circRNAs within microenvironment. Furthermore, cancer diagnosis treatment emphasized, which could pave way for development effective targeted therapies.
Language: Английский
Citations
0
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Feb. 19, 2025
In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.
Language: Английский
Citations
0