Integrating molecular, biochemical, and immunohistochemical features as predictors of hepatocellular carcinoma drug response using machine-learning algorithms DOI Creative Commons
Marwa Matboli,

Hiba S. Al-Amodi,

Abdelrahman Khaled

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 16, 2024

Introduction Liver cancer, particularly Hepatocellular carcinoma (HCC), remains a significant global health concern due to its high prevalence and heterogeneous nature. Despite the existence of approved drugs for HCC treatment, scarcity predictive biomarkers limits their effective utilization. Integrating diverse data types revolutionize drug response prediction, ultimately enabling personalized management. Method In this study, we developed multiple supervised machine learning models predict treatment response. These utilized classifiers such as logistic regression (LR), k-nearest neighbors (kNN), neural networks (NN), support vector machines (SVM), random forests (RF) using comprehensive set molecular, biochemical, immunohistochemical features targets three drugs: Pantoprazole, Cyanidin 3-glycoside (Cyan), Hesperidin. A performance metrics complete reduced were reported including accuracy, precision, recall (sensitivity), specificity, Matthews Correlation Coefficient (MCC). Results Discussion Notably, (NN) achieved best prediction accuracy where combined model molecular biochemical exhibited exceptional power, achieving solid 0.9693 ∓ 0.0105 average area under ROC curve (AUC) 0.94 0.06 coming from cross-validation iterations. Also, found seven features, one immunohistochemistry feature promising This method has potential significantly advance therapy by allowing more precise estimation assisting in identification strategies.

Language: Английский

Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives DOI
Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155303 - 155303

Published: April 28, 2024

Language: Английский

Citations

17
Emerging role of RNA modification and long noncoding RNA interaction in cancer DOI Creative Commons
Liqiong Yang,

Lu Tang,

Qi Min

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(6), P. 816 - 830

Published: Feb. 14, 2024

Abstract RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence progression of cancer through multiple pathways. The function expression these epigenetic regulators have gradually become a hot topic research. Mutation regulation noncoding RNA, lncRNA, play major role cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions its dysregulation can promote tumor metastasis. In this review, we summarize modifications lncRNAs. Furthermore, discuss relationship between modification lncRNA interaction various cancers. Therefore, review gives comprehensive understanding mechanisms by which affects cancers regulating lncRNAs, may shed new light on research provide insights into therapy.

Language: Английский

Citations

10
Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis DOI Creative Commons

Tamer A. Addissouky,

Majeed M. A. Ali, Ibrahim El Tantawy El Sayed

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 12, 2024

Abstract Background Liver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including collagen. It can progress to cirrhosis failure. Main body the abstract Multiple cellular signaling pathways drive hepatic stellate cell activation fibrogenesis. Advances in biomarkers, imaging modalities, omics platforms enable noninvasive diagnosis staging fibrosis. Emerging antifibrotic approaches include medications like pirfenidone, obeticholic acid, monoclonal antibodies targeting pro-fibrotic mediators. Cell therapies using mesenchymal stem cells demonstrate potential through paracrine immunosuppression. Tissue-engineered grafts biomaterial carriers for localized drug delivery are promising technologies. Microfluidic liver-on-a-chip with patient-derived provide unprecedented models study human test candidates. Short conclusion Significant has elucidated mechanisms underlying fibrogenesis uncovered novel therapeutic targets. Ongoing challenges translating preclinical findings, improving efficacy, enabling personalized precision medicine approaches. Further research into combinatorial therapies, tissue engineering technologies will advance treatment all causes.

Language: Английский

Citations

9
Role of m6A RNA Methylation in Ischemic Stroke DOI
Yayun Xu, Wenqiang Liu, Lijie Ren

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6997 - 7008

Published: Feb. 16, 2024

Language: Английский

Citations

6
The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma DOI Creative Commons

Zhaoqi Shi,

Shengxi Jin, Xiaolong Liu

et al.

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101534 - 101534

Published: Jan. 1, 2025

Language: Английский

Citations

0
New understandings of the genetic regulatory relationship between non-coding RNAs and m6A modification DOI Creative Commons
Song‐Tao Liu,

Dayong Xiang

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 6, 2023

One of the most frequent epigenetic modifications RNA in eukaryotes is N6 methyladenosine (m 6 A), which mostly present messenger RNAs. Through influence several processing stages, m A modification a crucial approach for controlling gene expression, especially cancer progression. It universally acknowledged that numerous non-coding RNAs (ncRNAs), such as microRNAs, circular RNAs, long and piRNAs, are also significantly affected by modification, complex genetic regulatory relationship between ncRNAs plays pivotal role development cancer. The connection offers an opportunity to explore oncogene potential mechanisms suggests could be vital biomarkers multiple cancers. In this review, we discuss interaction methylation cancer, summarize diagnostic prognostic clinical detection. Furthermore, our article includes some methodologies identifying sites when assessing biomarker potential.

Language: Английский

Citations

7
Current updates on the molecular and genetic signals as diagnostic and therapeutic targets for hepatitis B virus-associated hepatic malignancy DOI Creative Commons
Adane Adugna,

Yalew Muche,

Abateneh Melkamu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34288 - e34288

Published: July 1, 2024

Liver cancer caused by the hepatitis B virus (HBV) is third most common cancer-related cause of death worldwide. Early detection HBV-caused hepatic tumors increases likelihood a successful cure. Molecular and genetic signals are becoming more recognized as possible indicators HBV-associated malignancy how well treatment working. As result, we have discussed current literature on molecular sensors, including extracellular vesicle microRNAs (EV-miRNAs), long non-coding circulating RNAs (lncRNAs), vesicles (EVs), cell free DNA (cfDNA), for diagnosis forecasting HBV-related cancer. Extracellular such miR-335-5p, miR-172-5p, miR-1285-5p, miR-497-5p, miR-636, miR-187-5p, miR-223-3p, miR-21, miR-324-3p, miR-210-3p, miR-718, miR-122, miR-522, miR-0308-3p, miR-375 essential posttranscriptional regulation oncogenes in cells epigenetic modulation many internal external signaling pathways HBV-induced carcinogenesis. LncRNAs like lnc01977, HULC (highly up-regulated liver cancer), MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), HOTAIR (hox antisense intergenic RNA) been demonstrated to control hepatic-tumors growth, relocation, encroachment, resiliency. They also involved immune tracking, shifting, vasculature oversight, genomic destabilization. EVs critical mediators multiple aspects liver-tumors angiogenesis, immunology, tumor formation, dissemination malignant hepatocytes. Furthermore, cfDNA contributes associated with tumors, mutations abnormal changes during tumorigenesis.

Language: Английский

Citations

1
The diverse landscape of RNA modifications in cancer development and progression DOI
Hyung Seok Kim, Jung Woo Eun, Seonghoe Jang

et al.

Genes & Genomics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Language: Английский

Citations

1
Therapeutic potential of natural antisense transcripts and various mechanisms involved for clinical applications and disease prevention DOI Creative Commons
Ashiq Ali, Aisha Khatoon,

Chenran Shao

et al.

RNA Biology, Journal Year: 2023, Volume and Issue: 21(1), P. 127 - 144

Published: Dec. 13, 2023

Antisense transcription, a prevalent occurrence in mammalian genomes, gives rise to natural antisense transcripts (NATs) as RNA molecules. These NATs serve agents of diverse transcriptional and post-transcriptional regulatory mechanisms, playing crucial roles various biological processes vital for cell function immune response. However, when their normal functions are disrupted, they can contribute human diseases. This comprehensive review aims establish the molecular foundation linking development disorders like cancer, neurodegenerative conditions, cardiovascular ailments. Additionally, we evaluate potential oligonucleotide-based therapies targeting NATs, presenting both advantages limitations, while also highlighting latest advancements this promising realm clinical investigation.

Language: Английский

Citations

2
Advancing prognostic understanding in hepatocellular carcinoma through the integration of genomic instability and lncRNA signatures: GILncSig model DOI
Marco Bocchetti, Gabriella Misso,

Silvia Zappavigna

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 16(9), P. 2774 - 2777

Published: Sept. 18, 2024

The recently published study by Duan et al introduces a promising method that combines genomic instability and long non-coding RNAs to improve the prognostic evaluation of hepatocellular carcinoma (HCC), deadly cancer associated with considerable morbidity mortality. This editorial aims analyze methodology, key findings, broader implications within fields gastroenterology oncological surgery, highlighting shift towards precision medicine in management HCC.

Language: Английский

Citations

0