Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

Medical Principles and Practice, Journal Year: 2015, Volume and Issue: 25(Suppl. 2), P. 41 - 59

Published: Dec. 17, 2015

Throughout history, natural products have played a dominant role in the treatment of human ailments. For example, legendary discovery penicillin transformed global existence. Presently, comprise large portion current-day pharmaceutical agents, most notably area cancer therapy. Examples include Taxol, vinblastine, and camptothecin. These structurally unique agents function by novel mechanisms action; isolation from sources is only plausible method that could led to their discovery. In addition terrestrial plants as for starting materials, marine environment (e.g., ecteinascidin 743, halichondrin B, dolastatins), microbes bleomycin, doxorubicin, staurosporin), slime molds epothilone B) yielded remarkable chemotherapeutic agents. Irrespective these advances, remains leading cause death worldwide. Undoubtedly, prevention highly preferable treatment. Cancer chemoprevention, use vaccines or inhibit, retard, reverse process carcinogenesis, another important approach easing this formidable public health burden. Similar play an field. There are many examples, including dietary phytochemicals such sulforaphane phenethyl isothiocyanate (cruciferous vegetables) resveratrol (grapes grape products). Overall, product research powerful discovering biologically active compounds with structures action. Given unfathomable diversity nature, it reasonable suggest chemical leads can be generated capable interacting possibly all therapeutic targets.

Language: Английский

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Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 69, P. 5 - 23

Published: Aug. 14, 2019

Language: Английский

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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Molecules, Journal Year: 2021, Volume and Issue: 26(4), P. 1109 - 1109

Published: Feb. 19, 2021

Despite the recent advances in field of chemically synthetized pharmaceutical agents, nature remains main supplier bioactive molecules. The research natural products is a valuable approach for discovery and development novel biologically active compounds possessing unique structures mechanisms action. Although their use belongs to traditional treatment regimes, plant-derived still cover large portion current-day agents. Their medical importance well recognized oncology, especially as an alternative limitations conventional chemotherapy (severe side effects inefficacy due occurrence multi-drug resistance). This review offers comprehensive perspective first blockbuster chemotherapeutic agents origin's (e.g. taxol, vincristine, doxorubicin) mechanism action using 3D representation. In addition portrayed step-by-step evolution from preclinical clinical evaluation most recently studied with potent antitumor activity resveratrol, curcumin, betulinic acid, etc.) terms anticancer possible indications or chemopreventive sensitizers. Finally, this describes several efficient platforms encapsulation targeted delivery cancer treatment.

Language: Английский

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Nutrition and Cancer, Journal Year: 2019, Volume and Issue: 72(3), P. 386 - 397

Published: July 9, 2019

Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing environmental agents, therapeutic etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), gastric cancer (7.81%). Natural compounds favorable against on count their anti-cancerous ability, easy avail efficient. natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent large diverse group used in prevention treatment cancer. flavonoids derived from different plant sources various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, possess antioxidant, anti-inflammation, as well activities through multiple pathways, they induce apoptosis breast, colorectal, prostate lower nucleoside diphosphate kinase-B activity lung, bladder colon inhibit cell-proliferation cell cycle arrest suppressing NF-kB pathway The current review summarized anticancer mechanisms action.

Language: Английский

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Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2021, Volume and Issue: Volume 14, P. 67 - 83

Published: Jan. 1, 2021

Obesity is recognized as a severe threat to overall human health and associated with type 2 diabetes mellitus, dyslipidemia, hypertension, cardiovascular diseases. Abnormal expansion of white adipose tissue involves increasing the existing adipocytes' cell size or number through differentiation new adipocytes. Adipogenesis process proliferation adipocyte precursor cells in mature As key determining adipocytes, it possible therapeutic approach for obesity. Therefore, necessary identify molecular mechanisms involved adipogenesis that could serve suitable targets. Reducing bodyweight regarded major benefit. Limited efficacy side effects drug interactions available anti-obesity treatment highlight constant need finding novel efficient safe ingredients. Numerous studies have recently investigated inhibitory natural products on lipid accumulation. Possible include induction apoptosis, cell-cycle arrest delayed progression, interference transcription factor cascade intracellular signaling pathways during early phase adipogenesis.

Language: Английский

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Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections

Molecules, Journal Year: 2018, Volume and Issue: 23(3), P. 624 - 624

Published: March 9, 2018

The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive resulting from enzymatic hydrolysis glucosinolates (GLs), the most abundant secondary metabolites botanical order Brassicales. Although activity ITCs against foodborne and plant pathogens well documented, little is known about their properties human pathogens. This review collects studies that focus on this topic. Particular will be put ITCs’ mechanism action for which current therapeutic solutions deficient therefore prime importance public health. Our purpose was evaluation potential to replace or support common antibiotics. Even though appear effective important pathogens, including bacteria with resistant phenotypes, majority did not show comparable results thus it very difficult compare different ITCs. For reason, a standard method should used further needed.

Language: Английский

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Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products

Molecules, Journal Year: 2021, Volume and Issue: 26(13), P. 4100 - 4100

Published: July 5, 2021

Lung cancer is one of the most common cancers and has a high mortality rate. Due to its incidence, clinical management disease remains major challenge. Several reports have documented relationship between phosphatidylinositol-3-kinase (PI3K)/ protein kinase B (AKT)/ mammalian target rapamycin (mTOR) pathway lung cancer. The recognition this as notable therapeutic in mainly due central involvement initiation progression disease. Interest using natural synthetic medications these signaling pathways increased recent years, with promising results vitro, vivo, trials. In review, we focus on current understanding PI3K/AKT/mTOR tumor development. addition pathway, highlighted potential recently developed inhibitors based preclinical

Language: Английский

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Focus on Formononetin: Anticancer Potential and Molecular Targets

Cancers, Journal Year: 2019, Volume and Issue: 11(5), P. 611 - 611

Published: May 1, 2019

Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including the red clover (Trifolium pratense) Chinese plant Astragalus membranaceus. Formononetin’s antioxidant neuroprotective effects underscore its therapeutic use against Alzheimer’s disease. Formononetin has been under intense investigation for past decade as strong evidence on promoting apoptosis proliferation suggests anticancer agent diverse cancers. These properties are observed in multiple cancer cell models, breast, colorectal, prostate cancer. also attenuates metastasis tumor growth vivo studies. The beneficial exuded by formononetin can be attributed to antiproliferative cycle arrest inducing properties. regulates transcription factors growth-factor-mediated oncogenic pathways, consequently alleviating possible causes of chronic inflammation that linked survival neoplastic cells their resistance chemotherapy. As such, this review summarizes critically analyzes current potential therapy malignancies with special emphasis molecular targets.

Language: Английский

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Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi

Plants People Planet, Journal Year: 2020, Volume and Issue: 2(5), P. 463 - 481

Published: Sept. 1, 2020

Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals for global health challenges, including cancer, heart disease, dementia, malaria, are valued as traditional medicines worldwide. Global demand medicinal plants has threatened certain species, contributing to biodiversity loss depletion of natural resources that important the humanity. We consider evolving role in healthcare new challenges human arise. present current emerging scientific approaches, uncover preserve nature‐based solutions future, through harmonization with conservation strategies. Summary Non‐communicable diseases, cardiovascular diabetes, main causes deaths globally, communicable diseases such malaria tuberculosis affect billions people. provided our armory against these while some regions world, they continue a central systems medicines. Consequently, is driving factor loss. Yet future therapeutics from nature evolving. Scientific advances enabling untapped potential world's be explored their value, reveal other roles may improving well‐being; this demonstrates value capital an incentive conservation. Emerging technologies also offer hope safeguarding essential by revealing more sustainable sourcing products. This review discusses recent developments approaches discovery products medicines, well‐being, strategies harmonize therapeutic use its proactive solutions.

Language: Английский

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Natural products and their derivatives: Promising modulators of tumor immunotherapy

Journal of Leukocyte Biology, Journal Year: 2020, Volume and Issue: 108(2), P. 493 - 508

Published: July 17, 2020

A wealth of evidence supports the role tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed anticancer activities natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators from products, hot research topic worldwide. These works mainly focused on including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids bufalin digoxin), terpenoids paclitaxel artemisinins), polysaccharide extracts lentinan). Compelling data highlight that promising future immunotherapy. Considering importance significance this topic, we initially discussed integrated progress derivatives, target T cells, macrophages, B NKs, regulatory myeloid-derived suppressor inflammatory cytokines chemokines, immunogenic cell death, immune checkpoints. Furthermore, these compounds inactivate several key pathways, NF-κB, PI3K/Akt, MAPK, JAK/STAT pathways. Here, performed deep generalization, analysis, summarization previous achievements, progress, bottlenecks development We expect review to provide some insight for guiding research.

Language: Английский

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