Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: June 28, 2022

Abstract Cancer is one of the leading causes death worldwide, and factors responsible for its progression need to be elucidated. Exosomes are structures with an average size 100 nm that can transport proteins, lipids, nucleic acids. This review focuses on role exosomes in cancer therapy. We discuss how able modulate components tumor microenvironment influence proliferation migration rates cells. also highlight that, depending their cargo, suppress or promote cell enhance reduce response radio- chemo-therapies. In addition, we describe trigger chronic inflammation lead immune evasion by focusing ability transfer non-coding RNAs between cells other molecular signaling pathways such as PTEN PI3K/Akt cancer. Subsequently, use carriers anti-tumor agents genetic tools control progression. then tumor-derived carcinogenesis. Finally, devote a section study diagnostic prognostic clinical courses important treatment patients. provides comprehensive understanding therapy, therapeutic value remodeling microenvironment. Graphical

Language: Английский

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Clinical effects of curcumin in enhancing cancer therapy: A systematic review

BMC Cancer, Journal Year: 2020, Volume and Issue: 20(1)

Published: Aug. 24, 2020

Abstract Background Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The of curcumin include inhibiting the carcinogenesis, angiogenesis, tumour growth. This study aims determine Clinical different types cancers using systematic review approach. Methods A methodology adopted for undertaking detailed analysis cancer therapy. results presented this paper an outcome extracting findings studies selected from articles published international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed Web Science (ISI). These were thoroughly searched, relevant publications based on plausible keywords, accordance with aims, as follows: prevalence, curcumin, features, cancer. Results are derived several consumption chemotherapy drugs, highlighting increases effectiveness radiotherapy which improving patient’s survival time, increasing expression anti-metastatic proteins along reducing their side effects. Conclusion comprehensive confirms reduces or radiotherapy, resulting patients’ quality life. number reported that, increased patient time decreased tumor markers’ level.

Language: Английский

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Natural Products as Anticancer Agents: Current Status and Future Perspectives

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8367 - 8367

Published: Nov. 30, 2022

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds synthesized from natural by modifying their structures or using naturally occurring as building blocks in synthesis these for various purposes different fields, such biology, medicine, engineering. Multiple modern costly treatments applied to combat cancer limit its lethality, but results are not significantly refreshing. products, which a significant new therapeutic drugs, currently being investigated potential cytotoxic shown positive trend preclinical research prompted numerous innovative strategies order expedite clinical research. becoming increasingly important drug discovery due high molecular diversity novel biofunctionality. Furthermore, can provide superior efficacy safety unique properties. The objective current review is overview emergence treatment prevention cancer, chemosensitizers, immunotherapeutics, combinatorial therapies with other formulations mechanisms underlying

Language: Английский

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Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis

Advances in protein chemistry and structural biology, Journal Year: 2021, Volume and Issue: unknown, P. 73 - 120

Published: Jan. 1, 2021

Language: Английский

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Piceatannol: A natural stilbene for the prevention and treatment of cancer

Pharmacological Research, Journal Year: 2020, Volume and Issue: 153, P. 104635 - 104635

Published: Jan. 8, 2020

Language: Английский

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Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Cancers, Journal Year: 2020, Volume and Issue: 12(8), P. 2276 - 2276

Published: Aug. 14, 2020

Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence, discovery development novel multi-targeted agents to attenuate is great importance. In recent decades, phytochemicals dietary medicinal plants have been successfully introduced as alternative anticancer due their ability modulate numerous oncogenic oncosuppressive pathways. Rutin (also known rutoside, quercetin-3-O-rutinoside sophorin) an active plant-derived flavonoid that widely distributed various vegetables, fruits, plants, including asparagus, buckwheat, apricots, apples, cherries, grapes, grapefruit, plums, oranges, tea. has shown target inflammatory, apoptotic, autophagic, angiogenic mediators, nuclear factor-κB, tumor necrosis factor-α, interleukins, light chain 3/Beclin, B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein, caspases, vascular endothelial growth factor. A comprehensive critical analysis potential rutin molecular targets amongst types not performed previously. Accordingly, purpose this review present up-to-date evaluation multiple cellular mechanisms through which effects be exerted. current challenges limitations well future directions research also discussed.

Language: Английский

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NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105759 - 105759

Published: July 8, 2021

Language: Английский

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Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 272, P. 118491 - 118491

Published: July 27, 2021

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from widespread emergence drug resistance. Although doxorubicin (DOX) induces cell cycle arrest DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) been extensively utilized synthesizing nanoparticles as it interacts with CD44 expressed on surface cells. Cancer cells can take up HA-modified through receptor-mediated endocytosis. Various types nanostructures such carbon nanomaterials, lipid polymeric nanocarriers have modified HA enhance delivery acid-based advanced materials provide a platform co-delivery genes drugs along efficacy overcome chemoresistance. In present review, potential methods application are discussed.

Language: Английский

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The long and short non-coding RNAs modulating EZH2 signaling in cancer

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 2, 2022

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate developmental and biological processes their abnormal expression affects cancer progression. These can function as upstream mediators different signaling pathways enhancer zeste homolog 2 (EZH2) is among them. Briefly, EZH2 belongs to PRCs exert functional roles cells due its methyltransferase activity. gene via inducing H3K27me3. In the present review, our aim provide mechanistic discussion ncRNAs role regulating cancers. MiRNAs dually induce/inhibit affect downstream targets such Wnt, STAT3 EMT. Furthermore, miRNAs regulate therapy response affecting signaling. It noteworthy that reduce miRNA by binding promoter exerting Small-interfering (siRNA) short-hairpin (shRNA) synthetic, short capable reducing suppressing LncRNAs mainly targeting miRNAs. lncRNAs induce modulating expression. Circular (CircRNAs), like lncRNAs, areas discussed review focus on molecular leading clinical translation.

Language: Английский

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