Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Oct. 26, 2020
Huntington's
disease
(HD)
is
a
progressive,
multifaceted
neurodegenerative
associated
with
weight
loss
and
gut
problems.
Under
healthy
conditions,
tight
junction
(TJ)
proteins
maintain
the
intestinal
barrier
integrity
preventing
bacterial
translocation
from
lumen
to
systemic
circulation.
Reduction
of
TJs
expression
in
Parkinson's
patients
has
been
linked
increased
permeability-leaky
syndrome.
The
intestine
contains
microbiota,
most
dominant
phyla
being
Bacteroidetes
Firmicutes;
pathogenic
or
conditions
balance
between
these
bacteria
might
be
disrupted.
present
study
investigated
whether
there
evidence
for
an
permeability
dysbiosis
R6/2
mouse
model
HD.
Our
data
demonstrate
that
decreased
body
length
mice
accompanied
by
significant
decrease
colon
compared
wild
type
littermates,
without
any
changes
protein
levels
(occludin,
zonula
occludens).
Moreover,
we
found
altered
microbiota
relative
abundance
Firmicutes.
results
indicate
further
studies
investigating
clinical
relevance
findings
are
warranted.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
11
Published: Jan. 19, 2021
We
sought
to
determine
whether
immune
reactivity
occurs
between
anti-SARS-CoV-2
protein
antibodies
and
human
tissue
antigens,
molecular
mimicry
COVID-19
viral
proteins
tissues
could
be
the
cause.
applied
both
monoclonal
anti-SARS-Cov-2
(spike
protein,
nucleoprotein)
rabbit
polyclonal
(envelope
membrane
protein)
55
different
antigens.
found
that
SARS-CoV-2
had
reactions
with
28
out
of
representing
a
diversity
groups
included
barrier
proteins,
gastrointestinal,
thyroid
neural
tissues,
more.
also
did
selective
epitope
mapping
using
BLAST
showed
similarities
homology
spike,
nucleoprotein,
many
other
antigens
mitochondria
M2,
F-actin
TPO.
This
extensive
cross-reactivity
antigen
may
play
role
in
multi-system
disease
process
COVID-19,
influence
severity
disease,
precipitate
onset
autoimmunity
susceptible
subgroups,
potentially
exacerbate
subjects
have
pre-existing
autoimmune
diseases.
Very
recently,
were
approved
for
use
on
patients
COVID-19.
The
used
this
study
are
almost
identical
these
antibodies.
Thus,
our
results
can
establish
potential
risk
disorders
come
from
own
dreaded
virus,
thus
ensure
badly-needed
vaccines
treatments
being
developed
it
truly
safe
against
disease.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(19), P. 11245 - 11245
Published: Sept. 24, 2022
Modulating
the
gut
microbiome
and
its
influence
on
human
health
is
subject
of
intense
research.
The
microbiota
could
be
associated
not
only
with
gastroenterological
diseases
but
also
psychiatric
disorders.
importance
factors
such
as
stress,
mode
delivery,
role
probiotics,
circadian
clock
system,
diet,
occupational
environmental
exposure
in
relationship
between
brain
function
through
bidirectional
communication,
described
"the
microbiome-gut-brain
axis",
especially
underlined.
In
this
review,
we
discuss
link
intestinal
host
response
involving
different
pathways
nervous
system
(e.g.,
neurotransmitters,
endocrine
immunological
mechanisms,
or
bacterial
metabolites).
We
review
alterations
their
results
development
disorders,
including
major
depressive
disorder
(MDD),
schizophrenia
(SCZ),
bipolar
(BD),
autism
spectrum
(ASD),
attention-deficit
hyperactivity
(ADHD).
Chronic Stress,
Journal Year:
2022,
Volume and Issue:
6
Published: Jan. 1, 2022
Lipopolysaccharide
(LPS)
is
the
main
structural
component
of
outer
membrane
most
Gram-negative
bacteria
and
has
diverse
immunostimulatory
procoagulant
effects.
Even
though
LPS
well
described
for
its
role
in
pathology
sepsis,
considerable
evidence
demonstrates
that
LPS-induced
signalling
immune
dysregulation
are
also
relevant
pathophysiology
many
diseases,
characteristically
where
endotoxaemia
less
severe.
These
diseases
typically
chronic
progressive
nature
span
broad
classifications,
including
neurodegenerative,
metabolic,
cardiovascular
diseases.
This
Review
reappraises
mechanisms
emphasises
crucial
contribution
to
multiple
beyond
conventional
sepsis.
perspective
asserts
new
ways
approaching
by
targeting
LPS-driven
pathways
may
be
therapeutic
benefit
a
wide
range
inflammatory
conditions.
Frontiers in Microbiology,
Journal Year:
2018,
Volume and Issue:
9
Published: Jan. 30, 2018
Adverse
fluctuations
in
the
distribution
of
intestinal
microbiome
cohort
has
been
associated
with
onset
intra-
and
extra-intestinal
inflammatory
conditions,
like
metabolic
syndrome
(MetS)
it's
hepatic
manifestation,
non-alcoholic
fatty
liver
disease
(NAFLD).
The
microbial
community
obese
compared
to
lean
subjects
shown
undergo
configurational
shifts
various
genera,
including
but
not
limited
increased
abundances
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 24, 2023
Gastrointestinal
cancer
represents
one
of
the
most
diagnosed
types
cancer.
Cancer
is
a
genetic
and
multifactorial
disease,
influenced
by
host
environmental
factors.
It
has
been
stated
that
20%
caused
microorganisms
such
as
Helicobacter
pylori
,
hepatitis
B
C
virus,
human
papillomavirus.
In
addition
to
these
well-known
associated
with
cancer,
it
shown
differences
in
composition
microbiota
between
healthy
individuals
patients.
Some
studies
have
suggested
existence
selected
their
metabolites
can
promote
or
inhibit
tumorigenesis
via
some
mechanisms.
Recent
findings
gut
microbiome
act
promotors
inhibitors.
gastrointestinal
be
dysregulation
expression
non-coding
RNA
(ncRNA)
through
microbiome.
This
review
will
summarize
latest
reports
regarding
relationship
among
microbiome,
ncRNAs,
The
potential
applications
diagnosing
treatments
discussed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 619 - 619
Published: Jan. 7, 2023
The
human
body
is
in
daily
contact
with
potentially
toxic
and
infectious
substances
the
gastrointestinal
tract
(GIT).
GIT
has
most
significant
load
of
antigens.
can
protect
intestinal
integrity
by
allowing
passage
beneficial
agents
blocking
path
harmful
substances.
Under
normal
conditions,
a
healthy
barrier
prevents
elements
from
entering
blood
stream.
However,
factors
such
as
stress,
an
unhealthy
diet,
excessive
alcohol,
antibiotics,
drug
consumption
compromise
composition
microbiota
homeostasis
function
intestine,
leading
to
increased
permeability.
Intestinal
hyperpermeability
allow
entry
through
junctions
epithelium,
which
pass
into
bloodstream
affect
various
organs
systems.
Thus,
leaky
gut
syndrome
dysfunction
are
associated
diseases,
inflammatory
bowel
disease
irritable
syndrome,
well
extra-intestinal
including
heart
obesity,
type
1
diabetes
mellitus,
celiac
disease.
Given
relationship
between
permeability
numerous
it
convenient
seek
excellent
strategy
avoid
or
reduce
increase
impact
dietary
nutrients
on
be
crucial
for
designing
new
strategies
patients
pathogenesis
gut-related
diseases
epithelial
dysfunctions.
In
this
review
article,
role
functional
ingredients
suggested
mediators
disorders.
