Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 13

Published: Oct. 13, 2019

Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates chain reactions, subsequently induces different types death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how propagate reactions products initiate apoptosis autophagy current models. We also during ferroptosis, summarized pathological conditions illness. aim bring more global integrative sight know ROS-induced occurs among

Language: Английский

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Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Biomaterials, Journal Year: 2021, Volume and Issue: 277, P. 121110 - 121110

Published: Aug. 30, 2021

Language: Английский

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The role of cellular reactive oxygen species in cancer chemotherapy

Journal of Experimental & Clinical Cancer Research, Journal Year: 2018, Volume and Issue: 37(1)

Published: Oct. 31, 2018

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis cancer cells. It is widely accepted that the anticancer effect these due to induction oxidative stress ROS-mediated cell injury in cancer. However, various new therapeutic approaches targeting ROS have yielded mixed results. Since it impossible quantitatively detect dynamic tumors during after chemotherapy clinical settings, increasing interest apply mathematical modeling techniques predict for understanding complex tumor biology chemotherapy. This review outlines current role cells carcinogenesis chemotherapy, provides a critical analysis methods used quantitative detection discusses application predicting treatment responses. Finally, we provide insights on perspectives future development effective ROS-inducing agents or antioxidants treatment.

Language: Английский

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Role of oxidative stress in depression

Drug Discovery Today, Journal Year: 2020, Volume and Issue: 25(7), P. 1270 - 1276

Published: May 8, 2020

Language: Английский

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Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 552 - 552

Published: Feb. 5, 2022

Reactive oxygen and nitrogen species (RONS) are generated through various endogenous exogenous processes; however, they neutralized by enzymatic non-enzymatic antioxidants. An imbalance between the generation neutralization of oxidants results in progression to oxidative stress (OS), which turn gives rise diseases, disorders aging. The characteristics aging include progressive loss function tissues organs. theory explains that age-related functional losses due accumulation reactive (ROS), their subsequent damages tissue deformities. Moreover, diseases caused OS cardiovascular [CVDs], chronic obstructive pulmonary disease, kidney neurodegenerative cancer. OS, induced ROS, is different antioxidants prevents cells, organs from damage. However, prolonged decreases content antioxidant status cells reducing activities reductants antioxidative enzymes pathological conditions. Therefore, aim present review discuss mechanism ROS-induced signaling age-associated complications mediated toxic manifestations order devise effective preventive curative natural therapeutic remedies.

Language: Английский

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The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 66, P. 101249 - 101249

Published: Dec. 29, 2020

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism response to changes in the inflammatory microenvironment may play key role cartilage degeneration OA progression. Under conditions environmental stress, chondrocytes tend adapt their microenvironmental shifting from one metabolic pathway another, for example oxidative phosphorylation glycolysis. Similar occur other cells, including synoviocytes. Switching between these pathways implicated alterations that involve mitochondrial dysfunction, enhanced anaerobic glycolysis, altered lipid amino acid metabolism. The shift glycolysis mainly regulated AMP-activated protein kinase (AMPK) mechanistic target rapamycin (mTOR) pathways. Chondrocyte are likely be feature different phenotypes. Determining has revealed features pathogenesis. Future research should place greater emphasis on immunometabolism as means understand pathophysiology age-related OA. This knowledge will advance development new drugs against therapeutic targets significance.

Language: Английский

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Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, Journal Year: 2020, Volume and Issue: 10(2), P. 320 - 320

Published: Feb. 17, 2020

Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression endogenous antioxidant synthesis ROS-eliminating enzymes in response to electrophilic compounds inactivate negative regulator Keap1. Accumulating evidence has shown mitochondrial ROS (mtROS) activate Nrf2, often mediated by certain protein kinases, induce genes involved quality/quantity control. Mild physiological stress, such as caloric restriction exercise, elicits beneficial effects through a process known "mitohormesis." Exercise induces NOX4 heart, which activates increases endurance capacity. Mice transiently depleted SOD2 or overexpressing skeletal muscle-specific UCP1 exhibit Nrf2-mediated PGC1α-mediated biogenesis. ATF4 activation may transcriptional program enhances NADPH mitochondria might cooperate with system. In severe oxidative Klf9 expression, represses mtROS-eliminating enhance cell death. is inactivated pathological conditions, diabetes, but Keap1 down-regulation mtROS elimination rescues improves pathology. These reports aid us understanding roles pathophysiological alterations involving mtROS.

Language: Английский

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Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(2), P. 423 - 423

Published: Jan. 8, 2020

There are presently more than 18 known aflatoxins most of which have been insufficiently studied for their incidence, health-risk, and mechanisms toxicity to allow effective intervention control means that would significantly sustainably reduce incidence adverse effects on health economy. Among these, aflatoxin B1 (AFB1) has by far the studied; yet, many aspects range diseases it causes remain be elucidated. Its mutagenicity, tumorigenicity, carcinogenicity—which best known—still suffer from limitations regarding relative contribution oxidative stress reactive epoxide derivative (Aflatoxin-exo 8,9-epoxide) in induction diseases, as well its metabolic synthesis pathways. Additionally, despite well-established additive carcinogenicity between AFB1 other risk factors, e.g., hepatitis viruses B C, hepatotoxic algal microcystins, this synergy unclear. This study reviews recent advances field they cause humans animals.

Language: Английский

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A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy

Nutrients, Journal Year: 2019, Volume and Issue: 11(2), P. 474 - 474

Published: Feb. 23, 2019

Tea is one of the most widely consumed beverages worldwide, and available in various forms. Green tea richer antioxidants compared to other forms tea. composed polyphenols, caffeine, minerals, trace amounts vitamins, amino acids, carbohydrates. The composition varies depending on fermentation process employed produce it. phytochemicals present green are known stimulate central nervous system maintain overall health humans. Skin aging a complex mediated by intrinsic factors such as senescence, along with extrinsic damage induced external chronic exposure ultraviolet (UV) irradiation—A photoaging—Which can lead erythema, edema, sunburn, hyperplasia, premature aging, development non-melanoma melanoma skin cancers. UV cause either directly, through absorption energy biomolecules, or indirectly, increased production reactive oxygen species (ROS) nitrogen (RNS). potent source exogenous antioxidant candidates that could nullify excess endogenous ROS RNS inside body, thereby diminish impact photoaging. Several vivo vitro studies suggest supplementation increases collagen elastin fiber content, suppresses degrading enzyme MMP-3 skin, conferring an anti-wrinkle effect. precise mechanism behind anti-photoaging effect has not been explored yet. Studies using worm model have suggested lifespan extension depends DAF-16 pathway. Apart from this, reported stress resistance neuroprotective properties. Its scavenging activity makes it mediator, also regulate metal ions. It polyphenols induce expression different enzymes hinder DNA oxidative damage. Growing evidence suggests be used potential agent mediate neurodegenerative diseases, including Alzheimer’s disease. EGCG, abundant catechin tea, was found suppress neurotoxicity Aβ activates glycogen synthase kinase-3β (GSK-3β), inhibiting c-Abl/FE65—the cytoplasmic nonreceptor tyrosine kinase which involved nuclear translocation. Additionally, autophagy, revitalizing organism consuming able activate autophagy HL-60 xenographs increasing PI3 BECLIN-1. This manuscript describes anti-photoaging, resistance, properties functional foods—green

Language: Английский

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Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

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