Journal of Psychopathology and Clinical Science,
Journal Year:
2023,
Volume and Issue:
132(3), P. 297 - 313
Published: April 1, 2023
Psychopathology
emerges
from
the
dynamic
interplay
of
physiological
and
mental
processes
ecological
context.
It
can
be
seen
as
a
failure
recursive,
homeostatic
to
achieve
adaptive
re-equilibrium.
This
general
statement
actualized
with
consideration
polygenic
liability,
early
exposures,
multiunit
(multi-"level")
analysis
psychological
action
associated
neural
operations,
all
in
context
developmental
exposome.
article
begins
by
identifying
key
principles
clarifying
terms
necessary
disorder
theory.
then
ventures
sketch
model
that
highlights
epigenetic
dynamics
proposes
common
pathways
hypothesis
toward
psychopathology.
An
perspective
elevates
importance
systems,
particularly
life,
while
opening
door
new
mechanistic
discovery.
The
proposal
is
finite
number
biological
mechanisms
are
shared
across
most
risky
environments
(and
possibly
many
genetic
liabilities)
for
Perturbation
these
mediating
leads
development
A
focus
on
changes
multiple
units
time
points
render
problem
explaining
psychopathology
tractable.
Key
questions
include
mapping
recursive
over
time,
at
adequate
density,
disorders
unfold
development.
(PsycInfo
Database
Record
(c)
2023
APA,
rights
reserved).
Frontiers in Sports and Active Living,
Journal Year:
2022,
Volume and Issue:
4
Published: July 18, 2022
The
loss
of
muscle
mass
and
strength
in
elderly
population
(especially
after
the
age
65-70)
represents
a
public
health
problem.
Due
to
high
prevalence
frailty
older
adults,
cardiovascular
or
low-intensity
exercise
is
implemented
as
first
choice
option.
Although
beneficial
these
training
schemes
are
not
effective
strength-based
resistance
for
increasing
hypertrophy.
In
fact,
when
performed
progressively
under
professional
supervision,
has
been
proposed
an
important
valid
methodology
reduce
sarcopenia-related
problems.
this
mini-review,
we
only
summarize
benefits
weight
but
also
highlight
practical
recommendations
other
non-conventional
methods
(e.g.,
suspension
training)
part
integral
anti-sarcopenia
strategy.
Future
directions
including
cluster
set
configurations
high-speed
outlined.
BJPsych Open,
Journal Year:
2022,
Volume and Issue:
8(3)
Published: April 1, 2022
Summary
The
Ukrainian
refugee
crisis
highlights
the
many
issues
associated
with
trauma,
distress,
mental
and
physical
health,
culturally
competent
assessments,
meaningful
support
interventions.
This
requires
international
a
global
response,
as
hosting
countries
have
specific
competencies
capacities.
authors
hope
that
groundswell
of
concern
over
in
Ukraine
will
lead
not
only
to
comprehensive
response
needs
refugees
from
country
but
also
recognition
other
asylum
seekers
our
collective
moral
obligation
address
those
equitably.
JAMA Network Open,
Journal Year:
2023,
Volume and Issue:
6(5), P. e2313989 - e2313989
Published: May 18, 2023
Elevated
allostatic
load
(AL)
has
been
associated
with
adverse
socioenvironmental
stressors
and
tumor
characteristics
that
convey
poor
prognosis
in
patients
breast
cancer.
Currently,
the
association
between
AL
all-cause
mortality
cancer
is
unknown.To
examine
cancer.This
cohort
study
used
data
from
an
institutional
electronic
medical
record
registry
at
National
Cancer
Institute
Comprehensive
Center.
Participants
were
diagnoses
(stage
I-III)
January
1,
2012,
through
December
31,
2020.
Data
analyzed
April
2022
November
2022.AL
was
expressed
as
a
summary
score
calculated
by
assigning
1
point
for
biomarkers
worst
sample
quartile.
High
defined
greater
than
median.The
main
outcome
mortality.
A
Cox
proportional
hazard
models
robust
variance
tested
mortality.There
4459
(median
[IQR]
age,
59
[49-67]
years)
ethnoracial
distribution
of
3
Hispanic
Black
(0.1%),
381
non-Hispanic
(8.5%),
23
White
(0.5%),
3861
(86.6%),
27
other
race
(0.6%),
164
(3.7%).
The
mean
(SD)
2.6
(1.7).
(adjusted
relative
ratio
[aRR],
those
1.11;
95%
CI,
1.04-1.18),
single
marital
status
(aRR,
1.06;
1.00-1.12),
government-supplied
insured
(Medicaid
aRR,
1.14;
1.07-1.21;
Medicare
1.03-1.19)
had
higher
adjusted
who
White,
married/living
married,
or
privately
insured,
respectively.
Adjusting
sociodemographic,
clinical,
treatment
factors,
high
46%
increase
risk
(hazard
[HR],
1.46;
1.11-1.93)
over
low
AL.
Similarly,
compared
first
quartile,
third
quartile
(HR,
1.53;
1.07-2.18)
fourth
1.79;
1.16-2.75)
significantly
increased
risks
There
significant
dose-dependent
Furthermore,
remained
after
adjusting
Charlson
Comorbidity
Index.These
findings
suggest
reflective
socioeconomic
marginalization
Journal of Psychopathology and Clinical Science,
Journal Year:
2023,
Volume and Issue:
132(3), P. 297 - 313
Published: April 1, 2023
Psychopathology
emerges
from
the
dynamic
interplay
of
physiological
and
mental
processes
ecological
context.
It
can
be
seen
as
a
failure
recursive,
homeostatic
to
achieve
adaptive
re-equilibrium.
This
general
statement
actualized
with
consideration
polygenic
liability,
early
exposures,
multiunit
(multi-"level")
analysis
psychological
action
associated
neural
operations,
all
in
context
developmental
exposome.
article
begins
by
identifying
key
principles
clarifying
terms
necessary
disorder
theory.
then
ventures
sketch
model
that
highlights
epigenetic
dynamics
proposes
common
pathways
hypothesis
toward
psychopathology.
An
perspective
elevates
importance
systems,
particularly
life,
while
opening
door
new
mechanistic
discovery.
The
proposal
is
finite
number
biological
mechanisms
are
shared
across
most
risky
environments
(and
possibly
many
genetic
liabilities)
for
Perturbation
these
mediating
leads
development
A
focus
on
changes
multiple
units
time
points
render
problem
explaining
psychopathology
tractable.
Key
questions
include
mapping
recursive
over
time,
at
adequate
density,
disorders
unfold
development.
(PsycInfo
Database
Record
(c)
2023
APA,
rights
reserved).
