Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Nature, Journal Year: 2021, Volume and Issue: 592(7855), P. 524 - 533
Published: April 21, 2021
Language: Английский
Citations
1691
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 22, 2023
Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.
Language: Английский
Citations
792
Cell, Journal Year: 2022, Volume and Issue: 185(10), P. 1630 - 1645
Published: May 1, 2022
Atherosclerosis is an inflammatory disease of the large arteries that major cause cardiovascular (CVD) and stroke. Here, we review current understanding molecular, cellular, genetic, environmental contributions to atherosclerosis, from both individual pathway systems perspectives. We place emphasis on recent developments, some which have yielded unexpected biology, including previously unknown heterogeneity smooth muscle cells in atherosclerotic lesions, roles for senescence clonal hematopoiesis, links gut microbiome.
Language: Английский
Citations
682
Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 19(3), P. 384 - 408
Published: Dec. 7, 2021
Abstract Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy structural components. The emerging field immunometabolism highlights importance maintenance activities immune cells. Macrophages are embryo- or adult bone marrow-derived leukocytes that key healthy homeostasis but can also contribute pathologies such as metabolic syndrome, atherosclerosis, fibrosis cancer. Macrophage has largely been studied in vitro. However, different organs contain diverse macrophage populations specialize distinct often tissue-specific functions. This context specificity creates diverging challenges fulfill their homeostatic roles particular microenvironment conditions response pathological conditions. Here, we outline current knowledge on requirements adaptations macrophages located tissues during selected diseases.
Language: Английский
Citations
259
Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(5), P. 710 - 725
Published: Oct. 6, 2020
Language: Английский
Citations
157
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7910 - 7910
Published: April 26, 2023
Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).
Language: Английский
Citations
119
Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 238, P. 108176 - 108176
Published: March 26, 2022
Language: Английский
Citations
118
Circulation Research, Journal Year: 2022, Volume and Issue: 130(9), P. 1289 - 1305
Published: April 11, 2022
The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic coronary artery disease. However, the role cell type-specific setting atherosclerosis remains to be defined. We determined whether myeloid cell-specific regulates efferocytosis and atherosclerosis.
Language: Английский
Citations
82
Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2022, Volume and Issue: 42(4), P. 372 - 380
Published: Feb. 17, 2022
Most acute cardiovascular events are due to plaque rupture, with atheromas containing large necrotic cores and thin fibrous caps being more susceptible rupture lesions small thick protected from rupture. Atherosclerotic plaques comprised various extracellular matrix proteins, modified lipoprotein particles, cells of different origins, that is, vascular leukocytes. Although much has been revealed about the mechanisms lead instability, several key areas remain incompletely understood. This In-Focus Review highlights processes related cellular crosstalk role tissue microenvironment in determining cell function stability. Recent advances highlight critical underpinnings atherosclerotic vulnerability, particularly impairments ability macrophages clear dead phenotypic switching smooth muscle cells. However, these do not occur isolation, as between interactions their surrounding play a significant Understanding aspects within an may shed light on how modify behavior identify novel approaches transform rupture-prone into stable lesions.
Language: Английский
Citations
76
Genes, Journal Year: 2022, Volume and Issue: 13(5), P. 756 - 756
Published: April 25, 2022
The implication of the heterogeneous spectrum pro- and anti-inflammatory macrophages (Macs) has been an important area investigation over last decade. polarization Macs alters their functional phenotype in response to surrounding microenvironment. are major immune cells implicated pathogenesis atherosclerosis. A hallmark pathology atherosclerosis is accumulation pro-inflammatory M1-like coronary arteries induced by pro-atherogenic stimuli; these incapable digesting lipids, thus resulting foam cell formation atherosclerotic plaques. Recent findings suggest that progression stability plaques dependent on quantity infiltrated Macs, state ratios different types Mac populations. defined signature markers surface, as well factors intracellular intranuclear compartments. At same time, polarized also exhibit gene expression patterns, with differential cellular characteristics oxidative phosphorylation glycolysis. reflective metabolic states various diseases. In this review, we discuss differences between M2-like associated pathways, roles
Language: Английский
Citations
75