Canadian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 40(8), P. 1424 - 1444
Published: April 10, 2024
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 18, 2025
Language: Английский
Citations
2
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: July 4, 2022
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial differences might underlie this bias. As part of genetic studies heart mice, observe DNA levels function tend to be reduced females as compared males. We also expression genes encoding proteins are higher males human cohorts. test our hypothesis panel genetically diverse inbred strains termed the Hybrid Mouse Diversity Panel (HMDP). Indeed, find gene is highly correlated diastolic function, key trait HFpEF. Consistent this, "two-hit" mouse model HFpEF confirm differs between sexes strongly associated number traits. By integrating data from HMDP cohort, identify Acsl6 determinant function. validate its role using adenoviral over-expression heart. conclude underlie, part, bias
Language: Английский
Citations
65
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16053 - 16053
Published: Dec. 16, 2022
High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide attention. It has been reported that mitochondrial dysfunction is one of the most important mechanisms affecting pathogenesis CVDs. Mitochondrial DNA (mtDNA) mutations may result in impaired oxidative phosphorylation (OXPHOS), abnormal respiratory chains, and ATP production. In dysfunctional mitochondria, electron transport chain (ETC) uncoupled energy supply reduced, while reactive oxygen species (ROS) production increased. Here, we discussed analyzed relationship between mtDNA mutations, mitophagy, decreased OXPHOS, elevated ROS, CVDs from perspective dysfunction. Furthermore, explored current potential therapeutic strategies for by eliminating (e.g., editing replacement), enhancing improving OXPHOS capacity supplement with NAD+, nicotinamide riboside (NR), mononucleotide (NMN), nano-drug delivery), reducing ROS Coenzyme Q10 other antioxidants), dissected their respective advantages limitations. fact, some are still a long way achieving safe effective clinical treatment. Although establishing remains challenging, starting holds bright prospects.
Language: Английский
Citations
65
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 33
Published: March 31, 2022
Myocardial fibrosis refers to the pathological changes of heart structure and morphology caused by various reasons myocardial damage. It has become an important challenge in later clinical treatment acute infarction/ischemic cardiomyopathy or diabetes complicated with failure. Ginseng Dingzhi Decoction (GN), a Chinese herbal medicine, can reduce failure protect cardiomyocytes. We infer that this may be related interaction intestinal microbiota mitochondrial homeostasis. The regulatory mechanism GN on gut mitochondria not yet been elucidated. was analyzed 16S rRNA gene; fecal samples were sequenced statistically determine phenotype rats. In addition, regulate microbial population increases proportion short-chain fatty acids anti-inflammatory bacteria reduces conditional pathogens diabetic phenotype. results suggest improve injury regulating flora. Our data also show stress-type TAC (transverse aortic constriction) is accompanied severe cardiac hypertrophy, reduced function, redox imbalance, dysfunction. However, use intervention significantly function damage, maintain homeostasis cells under high glucose stimulation. Interestingly, through vitro experiments after TMBIM6 siRNA treatment, improvement effect cell damage regulation eliminated. indirectly mitophagy attenuate confirms further intervened cardiomyocytes metformin (MET) combination therapy. Research MET therapy level findings provide novel mechanistic insights for combined (myocardial fibrosis) pharmacological basis study medicine conventional drugs.
Language: Английский
Citations
45
Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 79(23), P. 2298 - 2305
Published: June 1, 2022
Language: Английский
Citations
44
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(3), P. 1565 - 1581
Published: March 17, 2022
Language: Английский
Citations
40
Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102474 - 102474
Published: Sept. 17, 2022
Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a clinical syndrome associated aging that is becoming more prevalent. Despite extensive studies, no effective treatment exists for HFpEF. Recent findings suggest oxidative stress contributes to the pathophysiology of DD, but molecular mechanisms underpinning redox-sensitive cardiac remodeling in DD remain obscure. Using transgenic mice mitochondria-targeted NOX4 overexpression (Nox4TG618) as model, we demonstrate NOX4-dependent mitochondrial induces measured by increased E/E', isovolumic relaxation time, Tau Glantz and reduced dP/dt
Language: Английский
Citations
40
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: Sept. 19, 2023
A large body of evidence indicates the existence a complex pathophysiological relationship between cardiovascular diseases and cancer. Mitochondria are crucial organelles whose optimal activity is determined by quality control systems, which regulate critical cellular events, ranging from intermediary metabolism calcium signaling to mitochondrial dynamics, cell death mitophagy. Emerging data indicate that impaired drives myocardial dysfunction occurring in several heart diseases, including cardiac hypertrophy, infarction, ischaemia/reperfusion damage metabolic cardiomyopathies. On other hand, diverse human cancers also dysregulate promote their initiation progression, suggesting modulating homeostasis may represent promising therapeutic strategy both cardiology oncology. In this review, first we briefly introduce physiological mechanisms underlying system, then summarize current understanding about impact dysregulated functions We discuss key increased risk complications secondary main anticancer strategies, highlighting potential strategies aimed at alleviating impairment-related tumorigenesis. It hoped summary can provide novel insights into precision medicine approaches reduce cancer morbidities mortalities.
Language: Английский
Citations
35
Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 212, P. 111818 - 111818
Published: April 27, 2023
Language: Английский
Citations
30
PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14952 - e14952
Published: March 13, 2023
Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease acute myocardial infarction. However, can lead ischemia injury (MIRI), which the prognosis of patients. Studying mechanisms MIRI help us improve treatment MIRI. The pathological process involves many ferroptosis mitophagy. Ferroptosis exacerbate MIRI, regulation mitophagy alleviate Both are closely related ROS, but there no clear understanding relationship between In this review, we analyzed according role mTOR, NLPR3 HIF. addition, simultaneous may be superior single for We summarized potential drugs that regulate and/or ferroptosis, hoping provide reference development methods treatment.
Language: Английский
Citations
26