JAMA Neurology, Journal Year: 2024, Volume and Issue: 81(5), P. 471 - 471
Published: March 25, 2024
Human brain development and maintenance is under both genetic environmental influences that likely affect later-life dementia risk.
Language: Английский
Circulation, Journal Year: 2023, Volume and Issue: 147(8)
Published: Jan. 25, 2023
Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs). Methods: through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual review published literature year before writing. 2023 is product full year’s worth effort 2022 by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional COVID-19 (coronavirus 2019) publications, as well monitoring benefits population, an enhanced focus equity across key domains. Results: Each chapters focuses different topic statistics. Conclusions: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.
Language: Английский
Citations
4232
Circulation, Journal Year: 2024, Volume and Issue: 149(8)
Published: Jan. 24, 2024
BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, obesity) factors (cholesterol, blood pressure, glucose control, metabolic syndrome) that contribute health. AHA Disease Stroke Statistical Update presents latest data on a range major clinical circulatory disease conditions (including brain health, complications pregnancy, kidney congenital rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary cardiomyopathy, failure, valvular venous thromboembolism, peripheral artery disease) associated outcomes quality care, procedures, economic costs). METHODS: AHA, through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States globally provide current information available annual review published literature year before writing. 2024 is product full year’s worth effort 2023 by dedicated volunteer clinicians scientists, committed government professionals, staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional global data, as well monitoring benefits population, an enhanced focus equity across key domains. RESULTS: Each chapters focuses different topic statistics. CONCLUSIONS: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.
Language: Английский
Citations
914
Circulation, Journal Year: 2023, Volume and Issue: 149(6), P. 430 - 449
Published: Nov. 10, 2023
BACKGROUND: Multivariable equations are recommended by primary prevention guidelines to assess absolute risk of cardiovascular disease (CVD). However, current have several limitations. Therefore, we developed and validated the American Heart Association Predicting Risk CVD EVENTs (PREVENT) among US adults 30 79 years age without known CVD. METHODS: The derivation sample included individual-level participant data from 25 sets (N=3 281 919) between 1992 2017. outcome was (atherosclerotic heart failure). Predictors traditional factors (smoking status, systolic blood pressure, cholesterol, antihypertensive or statin use, diabetes) estimated glomerular filtration rate. Models were sex-specific, race-free, on scale, adjusted for competing non-CVD death. Analyses conducted in each set meta-analyzed. Discrimination assessed using Harrell C-statistic. Calibration calculated as slope observed versus predicted decile. Additional predict subtype failure) include optional predictors (urine albumin-to-creatinine ratio hemoglobin A1c), social deprivation index also developed. External validation performed 3 330 085 participants 21 additional sets. RESULTS: Among 6 612 004 included, mean±SD 53±12 years, 56% women. Over a follow-up 4.8±3.1 there 211 515 incident total events. median C-statistics external 0.794 (interquartile interval, 0.763–0.809) female 0.757 (0.727–0.778) male participants. calibration slopes 1.03 0.81–1.16) 0.94 (0.81–1.13) participants, respectively. Similar estimates discrimination atherosclerotic CVD– failure–specific models. improvement small but statistically significant when urine ratio, A1c, added together base model (ΔC-statistic [interquartile interval] 0.004 [0.004–0.005] 0.005 [0.004–0.007] respectively). improved significantly those with marked albuminuria (>300 mg/g; 1.05 [0.84–1.20] 1.39 [1.14–1.65]; P =0.01). CONCLUSIONS: PREVENT accurately precisely subtypes large, diverse, contemporary routinely available clinical variables.
Language: Английский
Citations
216
The Lancet Public Health, Journal Year: 2023, Volume and Issue: 8(10), P. e820 - e826
Published: Sept. 28, 2023
Healthy sleep is essential for physical and mental health, social wellbeing; however, across the globe, particularly in developing countries, national public health agendas rarely consider health. Sleep should be promoted as an pillar of equivalent to nutrition activity. To improve a focus on education awareness, research, targeted policies are needed. We recommend educational programmes awareness campaigns; increasing, standardising, centralising data quantity quality every country globe; implementing sectors society. Efforts needed ensure equity inclusivity all people, those who most socially economically vulnerable, historically excluded.
Language: Английский
Citations
125
Circulation, Journal Year: 2023, Volume and Issue: 147(15), P. 1137 - 1146
Published: April 10, 2023
Cardiovascular disease may be the main reason for stagnant growth in life expectancy United States since 2010. The American Heart Association recently released an updated algorithm evaluating cardiovascular health (CVH)-Life's Essential 8 (LE8) score. We aimed to quantify associations of CVH levels, estimated by LE8 score, with a nationally representative sample US adults.
Language: Английский
Citations
88
Current Problems in Cardiology, Journal Year: 2022, Volume and Issue: 48(4), P. 101540 - 101540
Published: Dec. 14, 2022
Language: Английский
Citations
71
Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(6), P. 1134 - 1143
Published: Jan. 28, 2023
Language: Английский
Citations
71
European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(7), P. 593 - 600
Published: Feb. 8, 2023
Abstract Aims Whereas cardiovascular disease (CVD) metrics define risk in individuals aged over 40 years, the earliest lesions of CVD appear well before this age. Cardiovascular health (CVH) was proposed to improve factors and updated recently. This study aimed explore associations baseline long-term CVH assessed by ‘Life’s Essential 8’ with premature all-cause mortality young Chinese adults. Methods results A total 16 011 CVD-free participants 18–40 years were enrolled from Kailuan cohort study. The score ranged 0 100 categorized into low, moderate, high. Cox regressions used assess hazard ratios (HRs) for baseline, time-updated mean, time-varying outcomes. During a median follow-up 13 we identified 271 cases (1.7%) 219 (1.4%) mortality. lower associated higher mortality; adjusted HR low vs. high group 7.34 [95% confidence interval (CI), 3.19–16.89] 2.54 (95% CI, 1.27–5.06) CVH, 4.38 2.14–8.97) 1.99 1.06–3.71) 8.19 2.70–24.88) 4.28 1.70–10.81) respectively. Conclusion We observed an inverse gradient association adults, emphasizing importance keeping behaviours earlier life. Lay Summary longitudinal prospective showed health, as measured new Life’s 8 metrics, life.Baseline status (measured mean score) adults <40 years.Among eight LE8, scores while non-significant.
Language: Английский
Citations
71
Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(3)
Published: Jan. 23, 2023
Background Depression is a nontraditional risk factor for cardiovascular disease (CVD). Data on the association of depression and poor mental health with CVD suboptimal (CVH) among young adults are limited. Methods Results We used data from 593 616 (aged 18–49 years) 2017 to 2020 Behavioral Risk Factor Surveillance System, nationally representative survey noninstitutionalized US adults. Exposures were self‐reported days (PMHDs; categorized as 0, 1–13, 14–30 in past 30 days). Outcomes (composite myocardial infarction, angina, or stroke) CVH (≥2 factors: hypertension, hypercholesterolemia, overweight/obesity, smoking, diabetes, physical inactivity, inadequate fruit vegetable intake). Using logistic regression, we investigated PMHDs CVH, adjusting sociodemographic factors (and outcome). Of participants (mean age, 34.7±9.0 years), weighted prevalence was 19.6% (95% CI, 19.4–19.8), 2.5% 2.4–2.6). People had higher odds than those without (odds ratio [OR], 2.32 [95% 2.13–2.51]). There graded CVD. Compared individuals 0 PMHDs, 1 13 14 PHMDs 1.48 1.34–1.62) 2.29 2.08–2.51), respectively, after factors. The associations did not differ significantly by sex urban/rural status. Individuals (OR, 1.79 1.65–1.95]) compared depression, similar relationship between CVH. Conclusions associated premature Although this likely bidirectional, prioritizing may help reduce improve
Language: Английский
Citations
55
European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(15), P. 1676 - 1685
Published: May 25, 2023
Abstract Aims To evaluate the independent, mediating, interactive, and associated effects of Life's Essential 8 (LE8) genetic predisposition on risk cardiovascular outcomes all-cause mortality. Methods results We retrieved a total 254 783 individuals from UK Biobank. LE8 was determined by eight metrics (nicotine exposure, physical activity, diet, sleep, body mass index, blood pressure, glucose, lipids), characterized as low, moderate, high health (CVH). Genetic estimated using polygenic score (PRS). Cox regressions were performed to associations between LE8, PRS, outcomes. During median follow-up 12.53 years, mortality occurred in 10 257 197 473 participants, 2074 215 675, incident disease (CVD) 71 774 675. Individuals with moderate or CVH experienced lower [hazard ratios (HRs) 0.33 0.81] adverse compared their counterparts low CVH. A substantial proportion (16.1∼69.8%) could be attributable up 51.2% PRS mediated LE8. In group, had CVD (HR: 0.26, 95% confidence interval: 0.18, 0.39), those Conclusion Ideal risks mortality, more pronounced association observed for CVD. Improving according guidelines should encouraged, especially that indicate risk.
Language: Английский
Citations
51