Adiponectin–leptin ratio for the early detection of lean non-alcoholic fatty liver disease independent of insulin resistance DOI Creative Commons
Chia‐Wen Lu, Kuen‐Cheh Yang,

Yu‐Chiao Chi

et al.

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1), P. 634 - 642

Published: Feb. 15, 2023

Lean Non-alcoholic Fatty Liver Disease (NAFLD) shares a similar disease burden to those of their overweight counterparts and should be detected early. We hypothesized that the adiponectin-leptin ratio (AL ratio) could good marker for early detection lean NAFLD independent insulin resistance.A total 575 adults without diabetes were enrolled in community-based study. The subjects stratified into controls, NAFLD, simple overweight/obesity groups according body mass index (BMI) ultrasonographic fatty liver indicators. Serum adiponectin leptin levels measured by enzyme-linked immunosorbent assay. Multivariate logistic regression analyses performed estimate odds having relation tertiles serum AL concentration after adjustment. Receiver operating characteristic (ROC) applied evaluate diagnostic performance NAFLD.The mean age participants was 42.8 ± 11.5 years. Comparing with highest versus lowest tertile 0.28(95%CI: 0.12-0.69) Putting ratio, BMI, triglyceride, AST/ALT diagnosis ROC 0.85 (95% CI: 0.82-0.88), 0.83 CI 0.78-0.87) 0.86 081-0.91) all women men, respectively. (p < .001).The study revealed biomarker distinguish patients from controls resistance. [AQ3]Key messagesThe prevalence non-alcoholic increases globally is related diseases metabolic dysfunctions. subset early.Adiponectin-leptin associated severity steatosis predictor obese better than each single adipokine. To date, there no investigation explores specifically relationship between ratio.Our found sole regardless resistance NAFLD. Having adjustment age, sex, current smoking, exercise habits, HOMA-IR AST/ALT. (0.85; 95% 0.82-0.88). Further rigorous necessary promptly performed.

Language: Английский

The role of platelets in non-alcoholic fatty liver disease: From pathophysiology to therapeutics DOI
Navya Malladi, Md Jahangir Alam,

Subir Kumar Maulik

et al.

Prostaglandins & Other Lipid Mediators, Journal Year: 2023, Volume and Issue: 169, P. 106766 - 106766

Published: July 20, 2023

Language: Английский

Citations

14
Communication between nonalcoholic fatty liver disease and atherosclerosis: Focusing on exosomes DOI Creative Commons
Xiaona Zhao,

Xinxin Kong,

Zhoujun Cui

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 193, P. 106690 - 106690

Published: Jan. 4, 2024

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder on a global scale. Atherosclerosis (AS), leading cause of cardiovascular diseases, stands as primary contributor to mortality among patients diagnosed with NAFLD. However, precise etiology by which NAFLD causes AS remains unclear. Exosomes are nanoscale extracellular vesicles secreted cells, and considered participate in complex biological processes promoting cell-to-cell organ-to-organ communications. As containing protein, mRNA, non-coding RNA other bioactive molecules, exosomes can development respectively. Recently, studies have shown that also promote via secreting exosomes. Herein, we summarized recent advantages pathogenesis AS, highlighted role mediating information exchange between AS. Further, discussed how play prominent enabling diverse organs, delving into novel avenue for investigating link diseases their associated complications. The future directions emerging challenges listed regarding exosome-based therapeutic strategies under conditions.

Language: Английский

Citations

5
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic DOI Open Access
Arghya Samanta, Moinak Sen Sarma

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(4), P. 511 - 516

Published: April 24, 2024

The worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend metabolic syndrome, owing lifestyle changes. pathogenesis NAFLD has not been fully understood yet. Therefore, emerged as a public health concern in field hepatology and metabolisms worldwide. Recent changes nomenclature from dysfunction-associated steatotic have brought positive outlook understanding process doctor-patient communication. Lifestyle are main treatment modality. Recently, clinical trial using drugs that target ‘insulin resistance’ which driving force behind NAFLD, shown promising results. Further translational research needed better understand underlying pathophysiological mechanism may open newer avenues therapeutic targets. role gut dysbiosis etiopathogenesis use fecal microbiota modification should be studied extensively. Prevention this silent epidemic by spreading awareness early intervention our priority.

Language: Английский

Citations

5
The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat DOI Creative Commons
Loren Skudder‐Hill, Ivana R. Sequeira, Juyeon Ko

et al.

Obesity, Journal Year: 2024, Volume and Issue: 32(12), P. 2310 - 2320

Published: Nov. 10, 2024

Abstract Objective Previous studies have investigated the association between hepatic fat and intrapancreatic deposition (IPFD); however, results been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. aim present study was to use moderation analyses determine conditions under which is associated with IPFD. Methods All participants underwent 3T abdominal magnetic resonance imaging (MRI) spectroscopy. Hepatic IPFD were manually quantified by independent raters. Moderation performed adjustment for sex ethnicity. Results There 367 included. Adjusted overall cohort revealed that age, glycated hemoglobin (HbA 1c ), low‐density lipoprotein cholesterol (LDL‐C), high‐density (HDL‐C), triglycerides significant moderators ( p < 0.05) Ranges significance included age 61 years, HbA 45 mmol/mol, LDL‐C 157 mg/dL, HDL‐C > 36 203 mg/dL. Conclusions generally young middle‐aged adults good health, whereas link two depots becomes uncoupled older or individuals risk factors. image

Language: Английский

Citations

5
Adiponectin–leptin ratio for the early detection of lean non-alcoholic fatty liver disease independent of insulin resistance DOI Creative Commons
Chia‐Wen Lu, Kuen‐Cheh Yang,

Yu‐Chiao Chi

et al.

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1), P. 634 - 642

Published: Feb. 15, 2023

Lean Non-alcoholic Fatty Liver Disease (NAFLD) shares a similar disease burden to those of their overweight counterparts and should be detected early. We hypothesized that the adiponectin-leptin ratio (AL ratio) could good marker for early detection lean NAFLD independent insulin resistance.A total 575 adults without diabetes were enrolled in community-based study. The subjects stratified into controls, NAFLD, simple overweight/obesity groups according body mass index (BMI) ultrasonographic fatty liver indicators. Serum adiponectin leptin levels measured by enzyme-linked immunosorbent assay. Multivariate logistic regression analyses performed estimate odds having relation tertiles serum AL concentration after adjustment. Receiver operating characteristic (ROC) applied evaluate diagnostic performance NAFLD.The mean age participants was 42.8 ± 11.5 years. Comparing with highest versus lowest tertile 0.28(95%CI: 0.12-0.69) Putting ratio, BMI, triglyceride, AST/ALT diagnosis ROC 0.85 (95% CI: 0.82-0.88), 0.83 CI 0.78-0.87) 0.86 081-0.91) all women men, respectively. (p < .001).The study revealed biomarker distinguish patients from controls resistance. [AQ3]Key messagesThe prevalence non-alcoholic increases globally is related diseases metabolic dysfunctions. subset early.Adiponectin-leptin associated severity steatosis predictor obese better than each single adipokine. To date, there no investigation explores specifically relationship between ratio.Our found sole regardless resistance NAFLD. Having adjustment age, sex, current smoking, exercise habits, HOMA-IR AST/ALT. (0.85; 95% 0.82-0.88). Further rigorous necessary promptly performed.

Language: Английский

Citations

12