Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(37), P. 13783 - 13794
Published: Sept. 7, 2023
Alzheimer's
disease
(AD)
is
a
primary
neurodegenerative
disease.
It
can
be
caused
by
aging
and
brain
trauma
severely
affects
the
abilities
of
cognition
memory
patients.
Therefore,
it
seriously
threatens
mental
physical
health
humans
worldwide.
As
traditional
Chinese
medicine,
ginsenosides
have
been
proven
to
variety
pharmacological
activities.
Ginsenoside
Rh4
(Rh4)
one
rare
with
higher
activity
than
ordinary
ginsenosides,
but
its
effect
on
alleviating
AD
molecular
mechanism
not
studied.
Here,
we
investigated
anti-AD
effects
potential
mechanisms
using
an
mouse
model
induced
combination
AlCl3·6H2O
d-galactose.
The
results
showed
that
could
significantly
improve
ability
cognizance
reduce
neuronal
damage
in
mice.
Concurrently,
attenuates
amyloid
β
accumulation,
increases
density
dendritic
spines,
logically
inhibits
synaptic
structural
as
result
excessive
apoptosis
autophagy.
only
inhibit
inflammatory
response
overactivation
microglia
astrocytes,
levels
pro-inflammatory
factors,
increase
level
antioxidant
enzymes
serum,
enzyme
SOD1
hippocampus
also
hyperphosphorylation
tau
protein
mice
regulating
Wnt2b/GSK-3β/SMAD4
signaling
pathway.
Together,
this
study
provides
theoretical
basis
for
treatment
reveals
drug
AD.
Theranostics,
Journal Year:
2023,
Volume and Issue:
14(1), P. 159 - 175
Published: Nov. 15, 2023
Ischemic
stroke
poses
a
significant
health
burden
with
limited
treatment
options.
Lymphocyte
Cytosolic
Protein
1
(LCP1)
facilitates
cell
migration
and
immune
responses
by
aiding
in
actin
polymerization,
cytoskeletal
rearrangements,
phagocytosis.
We
have
demonstrated
that
the
long
non-coding
RNA
(lncRNA)
Maclpil
silencing
monocyte-derived
macrophages
(MoDMs)
led
to
LCP1
inhibition,
reducing
ischemic
brain
damage.
However,
role
of
MoDMs
remains
unknown.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Feb. 28, 2023
Central
nervous
system
(CNS)
disorders
exhibit
complex
neurophysiological
and
pathological
mechanisms,
which
seriously
affect
the
quality
of
life
in
patients.
Acupuncture,
widely
accepted
as
complementary
alternative
medicine,
has
been
proven
to
exert
significant
therapeutic
effects
on
CNS
diseases.
As
a
part
innate
immune
system,
NLRP3
inflammasome
contributes
pathogenesis
diseases
via
regulating
neuroinflammation.
To
further
explore
mechanisms
acupuncture
diseases,
our
study
focused
neuroinflammation
vascular
dementia,
Alzheimer’s
disease,
stroke,
depression,
spinal
cord
injury.
This
confirmed
that
activation
promotes
development
inhibiting
is
potential
key
target
for
treatment
In
addition,
it
concluded
alleviates
by
pathway,
thereby
improving
progression
provides
theoretical
basis
attenuate
improve
The FASEB Journal,
Journal Year:
2023,
Volume and Issue:
37(8)
Published: July 4, 2023
Abstract
Inflammatory
processes
are
activated
following
ischemic
stroke
that
lead
to
increased
tissue
damage
for
weeks
the
insult,
but
there
no
approved
therapies
target
this
inflammation‐induced
secondary
injury.
Here,
we
report
SynB1‐ELP‐p50i,
a
novel
protein
inhibitor
of
nuclear
factor
kappa
B
(NF‐κB)
inflammatory
cascade
bound
drug
carrier
elastin‐like
polypeptide
(ELP),
decreases
NF‐κB
induced
cytokine
production
in
cultured
macrophages,
crosses
plasma
membrane
and
accumulates
cytoplasm
both
neurons
microglia
vitro,
at
infarct
site
where
blood–brain
barrier
(BBB)
is
compromised
middle
cerebral
artery
occlusion
(MCAO)
rats.
Additionally,
SynB1‐ELP‐p50i
treatment
reduces
volume
by
11.86%
compared
saline‐treated
controls
24
h
MCAO.
Longitudinally,
improves
survival
14
days
with
effects
toxicity
or
peripheral
organ
dysfunction.
These
results
show
high
potential
ELP‐delivered
biologics
therapy
other
central
nervous
system
disorders
further
support
targeting
inflammation
stroke.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(37), P. 13783 - 13794
Published: Sept. 7, 2023
Alzheimer's
disease
(AD)
is
a
primary
neurodegenerative
disease.
It
can
be
caused
by
aging
and
brain
trauma
severely
affects
the
abilities
of
cognition
memory
patients.
Therefore,
it
seriously
threatens
mental
physical
health
humans
worldwide.
As
traditional
Chinese
medicine,
ginsenosides
have
been
proven
to
variety
pharmacological
activities.
Ginsenoside
Rh4
(Rh4)
one
rare
with
higher
activity
than
ordinary
ginsenosides,
but
its
effect
on
alleviating
AD
molecular
mechanism
not
studied.
Here,
we
investigated
anti-AD
effects
potential
mechanisms
using
an
mouse
model
induced
combination
AlCl3·6H2O
d-galactose.
The
results
showed
that
could
significantly
improve
ability
cognizance
reduce
neuronal
damage
in
mice.
Concurrently,
attenuates
amyloid
β
accumulation,
increases
density
dendritic
spines,
logically
inhibits
synaptic
structural
as
result
excessive
apoptosis
autophagy.
only
inhibit
inflammatory
response
overactivation
microglia
astrocytes,
levels
pro-inflammatory
factors,
increase
level
antioxidant
enzymes
serum,
enzyme
SOD1
hippocampus
also
hyperphosphorylation
tau
protein
mice
regulating
Wnt2b/GSK-3β/SMAD4
signaling
pathway.
Together,
this
study
provides
theoretical
basis
for
treatment
reveals
drug
AD.
