Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 509 - 520
Published: Jan. 1, 2024
Language: Английский
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(9), P. 1890 - 1898
Published: Dec. 14, 2023
Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to pathogenesis various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly elevated. Understanding role that inflammasome-mediated neuroinflammation plays in depression may be beneficial for future therapeutic strategies. this review, we aimed elucidate mechanisms lead activation as well provide insight into strategies target inflammasome. Moreover, outlined inflammasome, including inflammatory pathway inhibitors, natural compounds, other compounds been shown effective treating Additionally, summarized application inhibitors clinical trials Currently, there scarcity dedicated investigating applications treatment. The modulation microglia holds promise management Further investigations necessary ascertain efficacy safety these approaches potential novel antidepressant treatments.
Language: Английский
Citations
12
Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Language: Английский
Citations
0
Physiological Reports, Journal Year: 2025, Volume and Issue: 13(7)
Published: April 1, 2025
Abstract Depression is a prevalent psychological disorder frequently associated with neuroinflammation, and microRNAs (miRNAs) have been implicated in its pathogenesis. Acupuncture, widely used East Asia, has shown efficacy various neuropsychiatric conditions; however, miRNA‐related mechanisms remain unclear. Using an LPS‐induced depression model, we examined acupuncture's effects on depression‐like behaviors circulating exosomal miRNAs serum. Microarray data revealed multiple significantly altered by LPS or acupuncture, subsequent bioinformatics analyses (TargetScan, KEGG, Gene Ontology) identified pathways related to synaptic signaling, circadian regulation. Constructing miRNA–target gene network further suggested that acupuncture might modulate miRNA expression alleviate depressive symptoms. These findings not only support the therapeutic potential of but also propose candidate as novel biomarkers diagnostic tools for model. Overall, this study provides insights into anti‐inflammatory actions through miRNA‐mediated
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(5)
Published: May 1, 2025
ABSTRACT Background Vascular dementia, the second most common type of dementia globally after Alzheimer's disease, is associated with neuroinflammation. Activation NLRP3 inflammasome, an important pattern recognition receptor in human innate immunity, plays a key role pathogenesis vascular dementia. Results The inflammasome pathway destroys neuronal cells primarily through production IL‐18 and IL‐1β. Moreover, it exacerbates by producing IL‐18, IL‐1β, N‐terminal fragment GSDMD, which also contributes to cell death. Thus, blocking presents new therapeutic strategy for treating thereby delaying or curing disease more effectively mitigating adverse effects. Conclusions This review explores mechanisms summarizing current research strategies. Investigating activation can reveal from perspective propose innovative preventive treatment
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 5(1), P. 200137 - 200137
Published: March 1, 2024
Extensive global research has been conducted to explore the neural mechanisms involved in acupuncture treatment for central nervous system (CNS) disorders. However, there is a lack of bibliometric analysis specifically focusing on functional magnetic resonance imaging (fMRI) studies examining effects CNS diseases. This study aims fill this gap by offering theoretical framework current clinical application and future directions. It presents comprehensive overview state, hotspots, trends fMRI therapeutic applications potential diseases over past two decades. The publications were analyzed using VOSviewer 1.6.18 CiteSpace 6.1.R6 software running Java platform. All acquired from Science Citation Index-Expanded Web Core Collection. document types limited original articles review articles, with publication dates spanning October 24, 2003 2023. Only written English language considered analysis. advantages non-invasiveness, high spatial resolution, signals directly activity brain. Compared other three brain techniques, most significant decades, substantial increase. As 2023, 227 records identified. Notably, discernible upward trend exists domain's overall number annual publications. worth highlighting that China emerged as primary contributor field. five prominent topics explored encompassed concepts "acupuncture," "fMRI," "electroacupuncture," "functional connectivity," "stimulation." Furthermore, frontier areas investigation "migraine without aura," "ischemic stroke," "prophylaxis," "randomized controlled trial." have applications, topic expected increase rapidly research. Future will focus migraine aura, ischemic stroke, randomized trials. connected various areas, default mode network. In addition, strengthening collaboration among different academic groups across countries imperative.
Language: Английский
Citations
3
International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(1), P. 1190 - 1213
Published: May 16, 2023
Complementary and alternative system of medicine has been at the center drug discovery for different CNS disorders. Medicinal plants have in use healthcare settings interestingly fostered leads development aimed treating various diseases such as CND disorders, malaria, mycetoma, inflammation. Electroacupuncture (EA) ability to protect prolonged restraint stress, attenuate depressions, manage few Bacopa monnieri, Rhodiola rosea, Centella asiatica, Cannabis sativa, Curcuma longa, Cyperus rotundus, Morinda citrifolia, Withania somnifera are among most common used disorder. Bioactive compounds valtrate, curcumin, cannabinoids, apomorphine, pergolide, benzatropine, β-asarone, α-Asarone treat addiction, insomnia, depression, Alzheimer's disease, epilepsy, vitiligo, Parkinson's disease. These complementary medicines promising lead quest develop more drugs
Language: Английский
Citations
7
Neuroreport, Journal Year: 2024, Volume and Issue: 35(12), P. 780 - 789
Published: June 18, 2024
This study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (PSCI) rats through TLR4/NF-κB/NLRP3 signaling pathway on hippocampal microglia. Thirty male were randomly divided into three groups: sham surgery group, PSCI model with 10 in each group. Middle cerebral artery occlusion was used establish model. The Zea Longa method score rats’ neurological function. Electroacupuncture utilized for 21 days improve PSCI. tested using Morris water maze. Hematoxylin–eosin staining immunofluorescence find hippocampus’ pathological changes. concentration interleukin-1β, interleukin-6, tumor necrosis factor-α, interleukin-18 detected by ELISA. mRNA expression levels associated inflammatory corpuscles measured quantitative real-time PCR. protein TLR4, MyD88, NF-κB, NLRP3 western blotting. improved not only but also morphology. inhibited activation microglia pathway. reduced proinflammatory factors restrained NLRP3-associated cytokines. Its mechanism related inhibiting pathway, attenuating release factors, regulating brain.
Language: Английский
Citations
2
World Journal of Acupuncture - Moxibustion, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 509 - 520
Published: Jan. 1, 2024
Language: Английский
Citations
0