Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Language: Английский

Effects of elevated remnant cholesterol on outcomes of acute ischemic stroke patients receiving mechanical thrombectomy DOI
Mengmeng Li, Meng Wang, Yixin Zhao

et al.

Journal of Thrombosis and Thrombolysis, Journal Year: 2024, Volume and Issue: 57(3), P. 390 - 401

Published: Jan. 5, 2024

Language: Английский

Citations

4
MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke DOI

Jina Jiang,

Tingting Qi,

Li Li

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(1)

Published: Feb. 21, 2024

Language: Английский

Citations

4
Remnant cholesterol is an effective biomarker for predicting survival in patients with breast cancer DOI Creative Commons
Jinyu Shi, Tong Liu, Chenan Liu

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 22, 2024

Abstract Background Breast cancer is the most common malignancy in women worldwide. The relationship between remnant cholesterol (RC) and prognosis of patients with breast has not been clearly reported. This study investigated prognostic value RC predicting mortality cancer. Methods prospectively analysed 709 from Investigation on Nutrition Status Clinical Outcome Common Cancers (INSCOC) project. Restricted cubic splines were used to analyse dose-response mortality. Kaplan–Meier method was evaluate overall survival A Cox regression analyses performed assess independent association Inverse probability treatment weighting (IPTW) using propensity score reduce confounding. Sensitivity analysis after excluding underlying diseases times shorter than one year. Results linear identified risk all-cause ( p = 0.036). log-rank test showed that high levels had poorer those low 0.007). Univariate multivariate an factor for IPTW-adjusted sensitivity CR remained a factor. Conclusions cancer, higher have survival.

Language: Английский

Citations

4
Low remnant cholesterol and the subsequent risk of new-onset atrial fibrillation: A prospective cohort study DOI
Zhi-Teng Chen,

Da-Chuan Guo,

Jing‐Wei Gao

et al.

Heart Rhythm, Journal Year: 2024, Volume and Issue: 21(8), P. 1258 - 1266

Published: May 28, 2024

Language: Английский

Citations

4
Causal Associations Between Remnant Cholesterol Levels and Atherosclerosis-Related Cardiometabolic Risk Factors: A Bidirectional Mendelian Randomization Analysis DOI Open Access

Yu-Shien Ko,

Lung‐An Hsu, Semon Wu

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 157 - 157

Published: Jan. 26, 2025

Background: Despite the widespread use of lipid-lowering agents, risk atherosclerotic cardiovascular disease (ASCVD) remains; this residual has been attributed to remnant cholesterol (RC) levels. However, causal associations between RC levels and various atherosclerosis-related cardiometabolic vascular factors for ASCVD remain unclear. Methods: Using genetic biochemical data 108,876 Taiwan Biobank study participants, follow-up 31,790 imaging 18,614 we conducted a genome-wide association study, Functional Mapping Annotation analysis, bidirectional Mendelian randomization analyses identify determinants factors. Results: We found that higher were associated with prevalence or incidence analyzed The unveiled 61 lead variants determining analysis revealed 21 gene sets exhibiting strong enrichment signals lipid metabolism. Standard models adjusted nonlipid variables low-density lipoprotein unraveled forward diabetes mellitus, hypertension, microalbuminuria, metabolic liver disease. Reverse mellitus Conclusions: levels, mainly influenced by genes metabolism, exhibit factors, including This provides further insights into role in predicting ASCVD.

Language: Английский

Citations

0
Remnant cholesterol, a potential risk factor of metabolic dysfunction-associated fatty liver disease DOI Creative Commons
Xuanyu Hao, Dongyang Li,

Xingyong Huang

et al.

Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 18, 2025

This study aimed to explore the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) in an adult population United States. Data were collected from National Health Nutrition Examination Survey database during 2017–2020. Weighted multivariable logistic regression analyses receiver operating characteristic (ROC) curves used investigate risk of MAFLD. Subgroup interaction performed. To further possible non-linear relationship MAFLD, a restricted cubic spline was used. Among included 3633 participants, prevalence rate MAFLD 34.56%. After full adjustment, higher associated with (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06; P = 0.02), compared lowest quartile cholesterol, highest more likely be (OR, 3.70; 95%CI, 2.37,5.76; < 0.0001). A found model, suggesting that initially increased rapidly then gradually slowed down. Remnant identified as potential factor for detected. Large-scale, high-quality prospective studies are required validate these findings.

Language: Английский

Citations

0
Association Between Estimated Cardiorespiratory Fitness Trajectory and Stroke and its Subtypes: A Prospective Cohort Study DOI

Hui Luo,

Shuohua Chen,

Xue Tian

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103923 - 103923

Published: Feb. 1, 2025

Language: Английский

Citations

0
High Cumulative Non-High-Density Lipoprotein-Cholesterol Concentration Increases the Risk of New-Onset Arterial Stiffness ― A Prospective Cohort Study ― DOI Open Access

Guanzhi Chen,

Yanjuan Chen, Yan Yao

et al.

Circulation Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

The relationship between cumulative non-high-density lipoprotein-cholesterol (cum-non-HDL-C) and the risk of new-onset arterial stiffness has not been characterized. A total 6,852 participants with 3 consecutive measurements cholesterol HDL-C a baseline brachial-ankle pulse wave velocity (baPWV) <1,400 cm/s during 2010-2011, 2012-2013, 2014-2015 were included. cum-non-HDL-C concentrations determined using time weighting, grouped: G1 <130 mg/dL, G2 130-159 G3 160-189 G4 ≥190 mg/dL. Cox models used to characterize relationships by calculating hazard ratios (HRs) 95% confidence intervals (CIs). Arterial (baPWV ≥1,800 cm/s) was present in 327 (4.77%) over median follow-up period 7.7 (interquartile range 7.2-8.2) years. After adjustment for multiple confounders, G2-4 had adjusted HRs (95% CIs) 1.12 (0.85, 1.48), 1.45 (1.05, 1.99), 2.52 (1.69, 3.74), respectively (P=0.0004), vs. G1. exposures 2, 4, 6 years 1.17 (0.87, 1.58), 1.46 (1.96, 2.01), 1.67 (1.14, 2.44), (P=0.0029), 0 Restricted cubic spline analysis revealed linear dose-response risk. high concentration prolonged exposure this increase stiffness. monitoring maintenance appropriate may reduce

Language: Английский

Citations

0
Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients DOI Creative Commons
Zebin Wang, Shihao Huang,

Na Tian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 21, 2025

In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein (HDL-C) levels significantly influence clinical outcomes. Current practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD mortality rates among CAPD treatment. Between January 1, 2005 December 31, 2016, a multi-center retrospective analysis of 2006 patients five hospitals China was conducted. Participants were split into subgroups accordance baseline serum restricted cubic spline cutoff value. The correlations between examined through case-specific hazard modeling. observation period documented 549 fatalities, deaths accounting for 269 cases. Kaplan-Meier revealed statistically significant divergence (log rank test P < 0.001) = 0.003). Elevated ratios showed increased (HR) (1.335, 95% CI, 1.112–1.603, 0.002) (1.319, 1.013–1.717, 0.040) compared lower counterparts. Nevertheless, no meaningful association found either RC (HR: 1.296, 0.992–1.691, 0.057) or HDL-C 0.887, 0.680–1.157, 0.376). independently predicts patients, persisting as prognostic marker after multivariable adjustment.

Language: Английский

Citations

0
Association between exposure to brominated flame retardants (BFRs) and blood lipid profiles in American adults: a cross-sectional study DOI Creative Commons
Yuxuan Wang, Zhihao Zhang, Nana Shen

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 27, 2025

Exposure to brominated flame retardants (BFRs) has been linked alterations in human metabolism and disease processes. However, the relationship between BFR exposure blood lipid levels remains unclear. This study aimed investigate potential association profiles American adults. A cross-sectional was conducted using data from National Health Nutrition Examination Survey (NHANES) 2005–2016. Serum concentrations of twelve BFRs, PBB153 eleven polybrominated diphenyl ethers (PBDEs), were quantified isotope dilution gas chromatography/high-resolution mass spectrometry (GC/HRMS). Blood levels, including total cholesterol (TC) high-density lipoprotein (HDL-C) measured enzymatically. The Friedewald equation used determine low-density (LDL-C): [LDL-C] = [TC] − [HDL-C] [TG/5]. Remnant (RC) calculated formula: [RC] [LDL-C]. Multivariable regression analyses applied examine associations individual BFRs TC, HDL-C, LDL-C, RC. overall mixtures with lipids evaluated quantile g-computation (QGC) weighted sum (WQS) regression. In order identify gender-specific differences, stratified mixture performed by gender. 3,154 eligible participants included. Nine a detection rate greater than 70% included analysis. Individually, PBB153, PBDE209, PBDE153, PBDE28 positively associated TC RC after adjusted all covariates. Furthermore, PBDE153 LDL-C. No found HDL-C. WQS QGC confirmed that demonstrates is increased RC, indicating an elevated risk dyslipidemia cardiovascular diseases.

Language: Английский

Citations

0