Cognitive Brain Networks and Enlarged Perivascular Spaces: Implications for Symptom Severity and Support Needs in Children with Autism DOI Open Access
Stefano Sotgiu, Giuseppe Barisano, Vanna Cavassa

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3029 - 3029

Published: April 27, 2025

Background/Objectives: The severity of autism spectrum disorder (ASD) is clinically assessed through a comprehensive evaluation social communication deficits, restricted interests, repetitive behaviors, and the level support required (ranging from 1 to 3) according DSM-5 criteria. Along with its varied clinical manifestations, neuroanatomy ASD characterized by heterogeneous abnormalities. Notably, brain MRI children often reveals an increased number perivascular spaces (PVSs) compared typically developing children. Our recent findings indicate that enlarged PVSs (ePVSs) are more common in younger male patients severe specific ePVS locations significantly associated symptoms. Methods: In this study, we mapped ePVSs across key regions three major cognitive networks-the Default Mode Network (DMN), combined Central Executive/Frontoparietal (CEN/FPN), Salience (SN)-in 36 individuals different symptom severities rehabilitation needs due ASD. We explored how number, size, location these networks related symptoms overall need for support. Results: results suggest DMN, CEN/FPN, SN strongly correlated certain symptoms, including verbal stereotypies, sensory disturbances. found mild association between needed daily living quality life. Conclusions: Dysfunction presence has significant impact on However, assistance may also be influenced other comorbid conditions dysfunctions smaller, overlapping networks.

Language: Английский

The role of the salience network in cognitive and affective deficits DOI Creative Commons
J. Schimmelpfennig,

Jan Topczewski,

Wojciech Kossut Zajkowski

et al.

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 20, 2023

Analysis and interpretation of studies on cognitive affective dysregulation often draw upon the network paradigm, especially Triple Network Model, which consists default mode (DMN), frontoparietal (FPN), salience (SN). DMN activity is primarily dominant during leisure self-monitoring processes. The FPN peaks task involvement exertion. Meanwhile, SN serves as a dynamic “switch” between FPN, in line with demand. In domains, dysfunctions involving are connected to broad spectrum deficits maladaptive behavioral patterns variety clinical disorders, such depression, insomnia, narcissism, PTSD (in case hyperactivity), chronic pain, anxiety, high degrees neuroticism, schizophrenia, epilepsy, autism, neurodegenerative illnesses, bipolar disorder hypoactivity). We discuss neurological data from various research domains present an integrated perspective indicating that these conditions can be associated widespread disruption predictive coding at multiple hierarchical levels. delineate fundamental ideas brain paradigm contrast them conventional modular method first section this article. Following this, we outline interaction model key functional networks highlight recent coupling SN-related impairments.

Language: Английский

Citations

126
Frontostriatal salience network expansion in individuals in depression DOI Creative Commons
Charles J. Lynch, Immanuel Elbau, Tommy Ng

et al.

Nature, Journal Year: 2024, Volume and Issue: 633(8030), P. 624 - 633

Published: Sept. 4, 2024

Language: Английский

Citations

56
Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder DOI Creative Commons
Qian Li, Youjin Zhao,

Yongbo Hu

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 106, P. 105255 - 105255

Published: July 19, 2024

Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found be altered major depressive disorder (MDD). Both symptoms and cognitive impairments are prominent features MDD, but case-control differences controllability between MDD controls can not fully interpret contribution both clinical cognition linked patterns among them MDD.

Language: Английский

Citations

24
The brain’s cingulo-opercular action-mode network DOI Open Access
Nico U.F. Dosenbach, Marcus E. Raichle, Evan M. Gordon

et al.

Published: Jan. 27, 2024

The brain is always intrinsically active, utilizing energy at high rates, while moving between global functional modes. Awake modes are tied to corresponding behavioral states. During goal-directed behavior, the enters an action-mode of function. In action-mode, arousal heightened, attention focused externally, and action plans created, converted movements, continuously updated based on relevant feedback, such as pain. Here, we synthesize classical recent human animal evidence that brain’s created maintained by network (AMN), which had previously identified named cingulo-opercular (CON) its anatomy. Controlling accounts for large variety functions associated with AMN, increasing arousal, processing instructional cues, task general initiation transients, sustained goal maintenance, planning, sympathetic drive (e.g., connectivity adrenal medulla) controlling physiology internal organs, well action-relevant bottom-up signals pain, errors viscerosensation. mode space, AMN-generated antipole default-mode self-referential, emotional, memory processing.

Language: Английский

Citations

21
The brain’s action-mode network DOI
Nico U.F. Dosenbach,

Marcus E. Raichle,

Evan M. Gordon

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

14
Default mode network functional connectivity as a transdiagnostic biomarker of cognitive function DOI
Vaibhav Tripathi, Ishaan Batta, Andre Zamani

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results DOI Open Access
Ru Kong, R. Nathan Spreng, Aihuiping Xue

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Decades of neuroscience research has shown that macroscale brain dynamics can be reliably decomposed into a subset large-scale functional networks, but the specific spatial topographies these networks and names used to describe them vary across studies. Such discordance hampered interpretation convergence findings field. To address this problem, we have developed Network Correspondence Toolbox (NCT) permit researchers examine report correspondence between their novel neuroimaging results sixteen widely atlases, consistent with recommended reporting standards by Organization for Human Brain Mapping. The atlases included in toolbox show some topographical such as those labeled default or visual. naming varies particularly spanning frontoparietal association cortices. For reason, quantitative comparison multiple is benchmark findings. We provide several exemplar demonstrations using Connectome Project task fMRI UK Biobank independent component analysis maps illustrate how use NCT own through evaluation against published atlases. provides convenient means computing Dice coefficients spin test permutations determine magnitude statistical significance among user-defined existing atlas labels. also includes functionality incorporate additional future. adoption will make it easier network standardized manner, thus aiding reproducibility facilitating comparisons studies produce interdisciplinary insights.

Language: Английский

Citations

13
Connectivity analyses for task-based fMRI DOI Creative Commons
Shenyang Huang, Felipe De Brigard, Roberto Cabeza

et al.

Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 139 - 156

Published: April 30, 2024

Functional connectivity (FC) is conventionally defined by measuring the similarity between brain signals from two regions. The technique has become widely adopted in analysis of functional magnetic resonance imaging (fMRI) data, where it provided cognitive neuroscientists with abundant information on how regions interact to support complex cognition. However, past decade notion "connectivity" expanded both complexity and heterogeneity its application neuroscience, resulting greater difficulty interpretation, replication, cross-study comparisons. In this paper, we begin canonical notions then introduce recent methodological developments that either estimate some alternative form or extend analytical framework, hope bringing better clarity for neuroscience researchers.

Language: Английский

Citations

11
Resting-state dynamic functional connectivity in major depressive disorder: A systematic review DOI
Shuting Sun,

Chang Yan,

Shanshan Qu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111076 - 111076

Published: July 6, 2024

Language: Английский

Citations

10
Resting state functional brain connectivity in child and adolescent psychiatry: where are we now? DOI Creative Commons
Lucina Q. Uddin, F. Xavier Castellanos, Vinod Menon

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 196 - 200

Published: May 22, 2024

Abstract Approaching the 30th anniversary of discovery resting state functional magnetic resonance imaging (rsfMRI) connectivity, we reflect on impact this neuroimaging breakthrough field child and adolescent psychiatry. The study intrinsic brain architecture that rsfMRI affords across a wide range ages abilities has yielded numerous key insights. For example, now know many neurodevelopmental conditions are associated with more widespread circuit alterations multiple large-scale networks than previously suspected. emergence population neuroscience effective data-sharing initiatives have made large datasets publicly available, providing sufficient power to begin identify brain-based subtypes within heterogeneous clinical conditions. Nevertheless, several methodological theoretical challenges must still be addressed fulfill promises personalized In particular, incomplete understanding physiological mechanisms driving developmental changes in connectivity remains an obstacle further progress. Future directions include cross-species multimodal investigations illuminate such mechanisms. Data collection harmonization efforts span countries diverse cohorts urgently needed. Finally, incorporating naturalistic fMRI paradigms as movie watching should priority for future research efforts.

Language: Английский

Citations

9