Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 83, P. 384 - 398

Published: Jan. 20, 2021

Language: Английский

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SARS-CoV-2 Infection of Airway Epithelial Cells

Immune Network, Journal Year: 2021, Volume and Issue: 21(1)

Published: Jan. 1, 2021

Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading worldwide since its outbreak in December 2019, and World Health Organization declared it as a pandemic on March 11, 2020. SARS-CoV-2 is highly contagious transmitted through airway epithelial cells the first gateway. detected nasopharyngeal or oropharyngeal swab samples, viral load significantly high upper tract. The host cellular receptors cells, including angiotensin-converting enzyme transmembrane serine protease 2, have identified single-cell RNA sequencing immunostaining. expression levels of these molecules vary type, function, location such ciliated secretory olfactory alveolar well differ from to depending age, sex, comorbid diseases. Infected ex vivo experiments produce chemokines cytokines recruit inflammatory target organs. Same other infections, IFN signaling critical pathway for defense. Various studies are underway confirm pathophysiological mechanisms infection. Herein, we review entry, host-viral interactions, immune responses cells. We also discuss therapeutic options related reactions SARS-CoV-2.

Language: Английский

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Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research

The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 10(9), P. 900 - 915

Published: Aug. 16, 2022

Language: Английский

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COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 720 - 720

Published: Jan. 10, 2022

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes age-related perturbations in endothelial and adipose tissue, which are known characterize early aging process. This would explain long-lasting symptoms as result an accelerated Connective tissues such tissue musculoskeletal primary sites aging. Therefore, current literature was analyzed focusing patients. Hypovitaminosis D, increased fragility, calcium deficiency point bone aging, while joint muscle pain typical for respectively. These characteristics could be classified osteoarthritis-like phenotype. Exploration osteoarthritis well neuronal function, showed similar perturbations. At molecular level, attributed angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, inflammation. Finally, influence nicotinic cholinergic being evaluated new treatment strategy. combined with knowledge pave road

Language: Английский

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Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2022, Volume and Issue: 206(6), P. 712 - 729

Published: May 12, 2022

Patients with chronic obstructive pulmonary disease (COPD) develop more severe coronavirus (COVID-19); however, it is unclear whether they are susceptible to acute respiratory syndrome 2 (SARS-CoV-2) infection and what mechanisms responsible for disease.

Language: Английский

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