European Respiratory Journal,
Journal Year:
2023,
Volume and Issue:
61(4), P. 2300239 - 2300239
Published: March 1, 2023
Executive
summary
of
the
Global
Strategy
for
Prevention,
Diagnosis
and
Management
COPD
2023:
latest
evidence-based
strategy
document
from
Initiative
Chronic
Obstructive
Lung
Disease
(GOLD)
https://bit.ly/3KCaTGe
American Journal of Respiratory and Critical Care Medicine,
Journal Year:
2020,
Volume and Issue:
203(4), P. 414 - 423
Published: Nov. 19, 2020
Currently
the
diagnosis
of
chronic
obstructive
pulmonary
disease
(COPD)
requires
demonstration
airflow
limitation,
defined
as
a
post-bronchodilator
FEV
1
/FVC
<0.7,
measurement
that
remains
methodologically
robust
and
widely
available.FEV
is
one
most
powerful
predictors
clinically
relevant
outcomes
including
symptoms,
exacerbations
mortality.However,
reliable
data
suggest
respiratory
in
particular
bronchitis,
airway
abnormality
emphysema
detected
using
modern
imaging
techniques
such
computed
tomography
(CT),
certain
physiologic
measures
rapid
decline
DLCO
are
present
among
individuals
who
do
not
meet
spirometric
criteria
for
COPD.These
abnormalities
may
help
to
identify
at
increased
risk
developing
limitation
future.Here,
we
review
evidence
support
use
term
"pre-COPD"
with
symptoms
(e.g.,
"Non-Obstructive
Chronic
Bronchitis"
(NOCB)),
low
DLCO)
and/or
(e.g.CT
emphysema)
but
spirometry
normal
range,
COPD
by
reduced
ratio.We
acknowledge,
however,
further
research
on
early
young
will
be
critical
develop
operable
definition
demonstrates
good
sensitivity
specificity.
Free Radical Biology and Medicine,
Journal Year:
2022,
Volume and Issue:
186, P. 1 - 16
Published: April 29, 2022
Redox
imbalance
is
an
vital
mechanism
for
COPD.
At
present,
insufficient
researches
have
been
conducted
on
the
protective
effect
of
hydrogen
sulfide
(H2S)
PM-induced
However,
whether
H2S
exerts
anti-injury
role
by
blocking
ferroptosis
and
restoring
redox
equilibrium
remain
to
be
investigated.
Human
lung
tissue
samples
were
collected
IHC
staining,
expressions
Nrf2,
ferritinophagy-
ferroptosis-related
proteins
observed.
The
WT
C57BL/6
Nrf2
knockout
mice
models
established
with
PM(200
μg
per
mouse).
NaHS(Exogenous
H2S)
was
injected
intraperitoneally
30
min
in
advance.
Twenty-nine
days
later,
tissues
evaluated
HE's
PERLS-DAB's
staining.
Meanwhile,
inflammation
oxidative
stress
indicators
iron
levels
assessed
corresponding
ELISA
kit.
Related
protein
detected
through
Western
blot.
BEAS-2B
cells
or
without
exposed
PM2.5
36
h.
Cell
viability,
mitochondrial
morphology,
inflammatory
cytokines,
antioxidant
factors,
levels,
autophagic
flux
ROS,
LIP
MitoROS,
MMP,
as
well
related
specific
methods,
respectively.
In
addition,
V5-Nrf2,
siRNA,
inhibitor
ML385,
PPAR-γ
GW9662,
autophagy
CQ,
chelator
DFO
Fer-1
used
verify
target
signaling
pathways.
We
found
that
COX2,
MDA
other
factors
increased,
while
markers
GPX4,
GSH
GSH-Px
significantly
decreased,
active
accumulation
COPD
patients,
PM-exposured
Nrf2-KO
PM2.5-mediated
cell
models.
NaHS
pretreatment
markedly
inhibited
emphysema
airway
alleviating
ferroptotic
changes
vivo
vitro.
With
use
V5-Nrf2
overexpression
plasmid,
siRNA
pathway
inhibitors,
we
activates
PPAR-γ,
inhibites
ferritinophagy
makers
LC3B,
NCOA4
FTH1
cells.
Moreover,
anti-ferroptotic
further
verified
activation
signal
MEF
This
research
suggested
alleviated
via
balance
inhibiting
regulating
Nrf2-PPAR-ferritinophagy
pathway.
Gut,
Journal Year:
2024,
Volume and Issue:
73(5), P. 751 - 769
Published: Feb. 8, 2024
Objective
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
major
cause
of
global
illness
and
death,
most
commonly
caused
by
cigarette
smoke.
The
mechanisms
pathogenesis
remain
poorly
understood,
limiting
the
development
effective
therapies.
gastrointestinal
microbiome
has
been
implicated
in
chronic
lung
diseases
via
gut-lung
axis,
but
its
role
unclear.
Design
Using
an
vivo
mouse
model
smoke
(CS)-induced
COPD
faecal
microbial
transfer
(FMT),
we
characterised
microbiota
using
metagenomics,
proteomics
metabolomics.
Findings
were
correlated
with
airway
systemic
inflammation,
gut
histopathology
function.
Complex
carbohydrates
assessed
mice
high
resistant
starch
diet,
16
patients
randomised,
double-blind,
placebo-controlled
pilot
study
inulin
supplementation.
Results
FMT
alleviated
hallmark
features
(inflammation,
alveolar
destruction,
impaired
function),
pathology
immune
changes.
Protective
effects
additive
to
smoking
cessation,
CS-associated
after
antibiotic-induced
depletion
was
sufficient
increase
inflammation
while
suppressing
colonic
immunity
absence
CS
exposure.
Disease
relative
abundance
Muribaculaceae,
Desulfovibrionaceae
Lachnospiraceae
family
members.
Proteomics
metabolomics
identified
downregulation
glucose
metabolism
microbiota,
supplementation
or
human
complex
improved
outcomes.
Conclusion
contributes
can
be
targeted
therapeutically.
Journal of Clinical Medicine,
Journal Year:
2021,
Volume and Issue:
10(13), P. 2889 - 2889
Published: June 29, 2021
Chronic
obstructive
pulmonary
disease
(COPD),
the
frequently
fatal
pathology
of
respiratory
tract,
accounts
for
half
a
billion
cases
globally.
COPD
manifests
via
chronic
inflammatory
response
to
irritants,
tobacco
smoke.
The
progression
from
early
onset
advanced
leads
loss
alveolar
wall,
hypertension,
and
fibrosis
epithelium.
Here,
we
focus
on
epidemiology,
progression,
biomarkers
with
particular
connection
lung
cancer.
Dissecting
cellular
molecular
players
in
disease,
aim
shed
light
role
smoking,
which
is
responsible
or
at
least
more
severe
symptoms
worse
patient
outcomes.
We
summarize
conditions,
as
well
EMT
fibroblasts
establishing
cancer-prone
microenvironment,
i.e.,
soil
'COPD-derived'
highlight
that
major
health
problem
can
be
alleviated
smoking
cessation,
diagnosis,
abandonment
usage
biomass
fuels
global
basis.
