Dry eye disease DOI Creative Commons

Annie L. Nguyen,

Ajay Kolluru,

Talia Beglarian

et al.

Taiwan Journal of Ophthalmology, Journal Year: 2023, Volume and Issue: 13(1), P. 3 - 12

Published: Jan. 1, 2023

Dry eye disease (DED) is a common chronic ocular disease. DED can have significant impact on visual function, causing disturbances to comfort, daily activities, and general quality of life. The varied nature makes it difficult point specific cause the syndrome. However, current literature agrees that inflammation cornea conjunctiva plays major role in its pathogenesis. Therapies targeted toward shown success treatment DED. purpose this review provide an overview prevalence inflammatory pathophysiology discussion available anti-inflammatory therapies including following: Nonsteroidal drugs, corticosteroids, other hormonal therapies, nonsteroidal immunomodulators, biological tear replacement, antibiotics, dietary supplements, tea tree oil, intense pulsed light.

Language: Английский

Mechanisms of blue light-induced eye hazard and protective measures: a review DOI Creative Commons
Xinli Ouyang, Jing Yang,

Zexin Hong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 130, P. 110577 - 110577

Published: Aug. 4, 2020

The risk of blue light exposure to human health has attracted increased research attention. Blue light, with relatively high energy, can cause irreversible photochemical damage eye tissue. Excessive the tends a series alterations, such as oxidative stress, mitochondrial apoptosis, inflammatory apoptosis and DNA damage, resulting in development dry disease, glaucoma, keratitis. Accordingly, physical protection, chemical pharmaceutical protective measures, gene therapy, other methods are widely used clinical treatment hazard. We reviewed studies on possible light-induced signaling pathways mechanisms summarized therapeutic approaches addressing

Language: Английский

Citations

161

Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review DOI Creative Commons
Audrey Cougnard‐Grégoire, Bénédicte M. J. Merle, Tariq Aslam

et al.

Ophthalmology and Therapy, Journal Year: 2023, Volume and Issue: 12(2), P. 755 - 788

Published: Feb. 18, 2023

Exposure to blue light has seriously increased in our environment since the arrival of emitting diodes (LEDs) and, recent years, proliferation digital devices rich light. This raises some questions about its potential deleterious effects on eye health. The aim this narrative review is provide an update ocular and discuss efficiency methods protection prevention against light-induced injury. search relevant English articles was conducted PubMed, Medline, Google Scholar databases until December 2022. Blue exposure provokes photochemical reactions most tissues, particular cornea, lens, retina. In vitro vivo studies have shown that certain exposures (depending wavelength or intensity) can cause temporary permanent damage structures eye, especially However, currently, there no evidence screen use LEDs normal are human Regarding protection, currently a beneficial effect blocking lenses for diseases, age-related macular degeneration (AMD). humans, pigments (composed lutein zeaxanthin) represent natural by filtering light, be through intake from foods food supplements. These nutrients associated with lower risk AMD cataract. Antioxidants such as vitamins C, E, zinc might also contribute preventing oxidative stress. Currently, at domestic intensity levels retinotoxic eye. toxicity long-term cumulative dose-response unknown.

Language: Английский

Citations

75

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options DOI Creative Commons
Laura M. Periman, Victor L. Perez, Daniel R. Saban

et al.

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2020, Volume and Issue: 36(3), P. 137 - 146

Published: March 16, 2020

Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When system excessively stimulated and/or immunoregulatory mechanisms are disrupted, balance between phases dysregulated chronic surface inflammation can result, leading dry eye disease (DED). According Tear Film Ocular Surface Society Dry Eye Workshop II definition, DED multifactorial disorder characterized by impairment loss tear homeostasis (hyperosmolarity), discomfort or pain, neurosensory abnormalities. Dysregulated responses result in damage, which further contributing factor pathology. Several therapeutics available break vicious circle prevent progression, including immunosuppressive agents (steroids) immunomodulators (cyclosporine lifitegrast). Given inflammatory nature DED, each these commonly used clinical practice. In this study, we review immunopathology molecular cellular actions current topical inform decision making.

Language: Английский

Citations

114

Digital Screen Use and Dry Eye: A Review DOI Creative Commons
Divy Mehra, Anat Galor

Asia-Pacific Journal of Ophthalmology, Journal Year: 2020, Volume and Issue: 9(6), P. 491 - 497

Published: Nov. 1, 2020

Prolonged and continuous daily use of digital screens, or visual display terminals (VDTs), has become the norm in occupational, educational, recreational settings. An increased global dependence on VDTs led to a rise associated complaints, including eye strain, ocular dryness, burning, blurred vision, irritation, name few. The principal causes for VDT-associated discomfort are abnormalities with oculomotor/vergence systems dry (DE). This review focuses latter, as advances research have identified symptomology surface parameters that shared between prolonged VDT users DE, particularly evaporative subtype. Several mechanisms been implicated blink anomalies, damaging light emission from modern devices, inflammatory changes. presence preexisting DE also explored an inciting exacerbating factor. We associations screens damage, therapeutic options, hoping raise awareness this entity goal reducing morbidity economic impact screen-associated disability.

Language: Английский

Citations

102

Recent advances of exosomes in immune-mediated eye diseases DOI Creative Commons
Na Li, Lu Zhao, Yankai Wei

et al.

Stem Cell Research & Therapy, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 30, 2019

Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora physiological pathological processes. Particularly, mounting evidence indicates that immunologically active can regulate both innate adaptive immune responses. Herein, we review recent advances the research several immune-mediated eye diseases, including Sjögren's syndrome (SS) dry eye, corneal allograft rejection, autoimmune uveitis, age-related macular degeneration (AMD). Additionally, discuss potential novel biomarkers drug delivery for diagnosis treatment diseases.

Language: Английский

Citations

83

Use of digital displays and ocular surface alterations: A review DOI
Cristian Talens‐Estarelles, José Vicente García‐Marqués, Alejandro Cerviño

et al.

The Ocular Surface, Journal Year: 2020, Volume and Issue: 19, P. 252 - 265

Published: Oct. 11, 2020

Language: Английский

Citations

74

Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels DOI
Pei‐Hsuan Lin,

Hong‐Jyuan Jian,

Yujia Li

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 141, P. 140 - 150

Published: Jan. 23, 2022

Language: Английский

Citations

66

Dopamine‐Based High‐Transparent Hydrogel as Bioadhesive for Sutureless Ocular Tissue Repair DOI Open Access

Yuna Qian,

Kejia Xu, Liangliang Shen

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: Aug. 4, 2023

Abstract Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed gelatin methacryloyl (GelMA) dopamine methacrylamide (DMA) developed by in situ oxidative free‐radical polymerization. This overcomes fundamental weakness mussel‐inspired adhesive copolymers clinical practice combining multiple favorable properties, including high light transmission, mechanical strength, biocompatibility. DMA significantly enhances corneal epithelial cells proliferation, migration on GelMA, prevents accumulation reactive oxygen species (ROS) cells. In rabbit models conjunctiva transplantation, able to decrease inflammatory response fibrosis formation induced suture surgical trauma. addition, stromal defect model reveals that Gel/DMA could effectively seal defects, accelerates re‐epithelialization, promotes wound healing. Thus, given advantages bioactivity simple preparation, represents promising strategy suture‐free repair.

Language: Английский

Citations

32

ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye DOI Creative Commons

Jingqing Mu,

Xiangyu Ding,

Yapeng Song

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Sjögren's syndrome‐related dry eye (SSDE) is a severe subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to glands for SSDE therapy safely and sustainably poses challenges in clinical practice. Herein, ROS‐responsive microneedle patch with detachable functionality (CE‐MN) developed enable straightforward minimally invasive administration gland area penetrating periocular skin. CE‐MN loaded cyclosporin A anti‐inflammatory drug epigallocatechin gallate, latter also serving as cross‐linker matrix. Poly(N‐isopropylacrylamide‐co‐butylacrylate), temperature‐sensitive polymer utilized fabricate separable layers that allow controlled detachment of base from needle, reducing patient discomfort. capable modulating release responding ROS, facilitating on‐demand release, accumulation Compared traditional drops, facilitated long‐acting delivery more than 48 h, demonstrating potent effects an mouse model scavenging ROS inhibiting proliferation Th1, Th17 cells, macrophages. Overall, this potentially offers novel approach treating other ocular chronic diseases.

Language: Английский

Citations

1

hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye DOI Creative Commons
Chaoqun Yu, Peng Chen, Jing Xu

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Sept. 3, 2020

Abstract The present study was set out to address the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles (hADSC-Evs) in a mouse model dry eye disease and investigate underlying mechanisms involved. hADSC-Evs drops were topically administered mice that subjected desiccating stress (DS). Clinical parameters ocular surface damage assessed with fluorescein staining, tear production PAS staining. For vitro studies, cell viability assay TUNEL staining performed corneal epithelial (HCECs) treated under hyperosmotic media. In addition, immunofluorescent Real-time PCR (qRT-PCR) Western blots used evaluated NLRP3, ASC, caspase-1, IL-1β expression levels. Compared vehicle control mice, topical showed decreased defects, increased production, goblet loss, as well reduced inflammatory cytokines production. vitro, could protect HCECs against stress-induced apoptosis. Mechanistically, treatment suppressed DS induced rises NLRP3 inflammasome formation, caspase-1 activation maturation. conclusion, effectively suppress response alleviate disease.

Language: Английский

Citations

57