Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy DOI Creative Commons
Xing Kang, Harry Cheuk-Hay Lau, Jun Yu

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 101478 - 101478

Published: April 1, 2024

Immunotherapy has emerged as a robust approach against cancer, yet its efficacy varied among individuals, accompanied by the occurrence of immune-related adverse events. As result, immunotherapy is far from satisfactory, and enormous efforts have been invested to develop strategies improve patient outcomes. The gut microbiome now well acknowledged for critical role in immunotherapy, with better understanding on host-microbes interaction context cancer treatment. Also, an increasing number trials conducted evaluate potential feasibility microbiome-targeting approaches enhance treatment patients. Here, metabolites (e.g., short-chain fatty acids, tryptophan metabolites) underlying mechanisms are explored. application that aim fecal microbiota transplantation, probiotics, dietary intervention) also elaborated, further discussion current challenges suggestions future research.

Language: Английский

Immunogenic cell stress and death DOI Open Access
Guido Kroemer,

Claudia Galassi,

Laurence Zitvogel

et al.

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 487 - 500

Published: Feb. 10, 2022

Language: Английский

Citations

870
Targeting the gut and tumor microbiota in cancer DOI
Elizabeth M. Park, Manoj Chelvanambi, Neal Bhutiani

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 690 - 703

Published: April 1, 2022

Language: Английский

Citations

333
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations DOI Creative Commons
Huiyuan Zhu, Dexi Bi, Youhua Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Jan. 17, 2022

The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate regimen that mimics the metabolism of fasting state to induce production ketone bodies. KD has long been established as remarkably successful dietary approach for treatment intractable epilepsy increasingly garnered research attention rapidly in past decade, subject emerging evidence promising therapeutic potential various diseases, besides epilepsy, from obesity malignancies. In this review, we summarize experimental and/or clinical efficacy safety different discuss possible mechanisms action based on recent advances understanding influence at cellular molecular levels. We emphasize may function through multiple mechanisms, which remain be further elucidated. challenges future directions implementation spectrum diseases have discussed. suggest that, with encouraging effects increasing insights into action, randomized controlled trials should conducted elucidate foundation use KD.

Language: Английский

Citations

245
Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes DOI Creative Commons

Nick Lung-Ngai Ting,

Harry Cheuk-Hay Lau, Jun Yu

et al.

Gut, Journal Year: 2022, Volume and Issue: 71(7), P. 1412 - 1425

Published: March 11, 2022

Despite the promising advances in novel cancer therapy such as immune checkpoint inhibitors (ICIs), limitations including therapeutic resistance and toxicity remain. In recent years, relationship between gut microbiota has been extensively studied. Accumulating evidence reveals role of defining efficacy toxicity. Unlike host genetics, can be easily modified via multiple strategies, faecal transplantation (FMT), probiotics antibiotics. Preclinical studies have identified mechanisms on how microbes influence treatment outcomes. Clinical trials also demonstrated potential modulation treatments. Herein, we review mechanistic insights microbial interactions with chemotherapy ICIs, particularly focusing interplay bacteria pharmacokinetics (eg, metabolism, enzymatic degradation) or pharmacodynamics immunomodulation) treatment. The translational basic findings clinical settings is then explored, using predictive biomarkers by antibiotics, probiotics, prebiotics, dietary modulations FMT. We further discuss current patients suggest essential directions for future study. era personalised medicine, it crucial to understand its cancer. Manipulating augment responses provide new into

Language: Английский

Citations

176
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications DOI Creative Commons
Lin-Yong Zhao,

Jia-Xin Mei,

Gang Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 13, 2023

Abstract In the past period, due to rapid development of next-generation sequencing technology, accumulating evidence has clarified complex role human microbiota in cancer and therapeutic response. More importantly, available seems indicate that modulating composition gut improve efficacy anti-cancer drugs may be feasible. However, intricate complexities exist, a deep comprehensive understanding how interacts with is critical realize its full potential treatment. The purpose this review summarize initial clues on molecular mechanisms regarding mutual effects between development, highlight relationship microbes immunotherapy, chemotherapy, radiation therapy surgery, which provide insights into formulation individualized strategies for management. addition, current emerging microbial interventions as well their clinical applications are summarized. Although many challenges remain now, great importance cannot overstated strategies, it necessary explore holistic approach incorporates modulation cancer.

Language: Английский

Citations

167
The Effects of Ketogenic Diet on the Immune System: A Meta-Analysis DOI Open Access
Nikolaos Tzenios,

Mary E. Tazanios,

Omasyarifa Binti Jamal Poh

et al.

Published: Dec. 21, 2022

Healthcare systems are mindful of the importance proper diet and nutrition in reducing risk various chronic diseases resulting hospitalizations. In this regard, they focusing on promoting intake foods comprising diets with health benefits, such as ketogenic diet. meta-analysis, a total 20 research studies effect immune system were analyzed. The obtained from three databases: Google Scholar, PubMed, Science Direct. From odd ratio similar outcome an improvement strength immunity between intervention control group was 0.76. On other hand, p-value for 0.09, 15 out being considered statistically significant. heterogeneity I2 = 15%, signifying low variability findings that is not by chance. Ketogenic indeed has positive effects immunity. Nonetheless, it can also result negative may harm human health.

Language: Английский

Citations

160
Targeting the gut microbiota for cancer therapy DOI
Miriam R. Fernandes, Poonam Aggarwal, Raquel Costa

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(12), P. 703 - 722

Published: Oct. 17, 2022

Language: Английский

Citations

154
Inflammation: the incubator of the tumor microenvironment DOI
Dominic Denk, Florian R. Greten

Trends in cancer, Journal Year: 2022, Volume and Issue: 8(11), P. 901 - 914

Published: July 28, 2022

Language: Английский

Citations

153
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application DOI
Sebastian J. Hofer, Didac Carmona‐Gutiérrez,

Melanie I. Mueller

et al.

EMBO Molecular Medicine, Journal Year: 2021, Volume and Issue: 14(1)

Published: Nov. 15, 2021

Language: Английский

Citations

143
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment DOI Creative Commons
Safae Terrisse, Lisa Derosa, Valerio Iebba

et al.

Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(9), P. 2778 - 2796

Published: May 7, 2021

Abstract The prognosis of early breast cancer (BC) relies on cell autonomous and immune parameters. impact the intestinal microbiome clinical outcome has not yet been evaluated. Shotgun metagenomics was used to determine composition fecal microbiota in 121 specimens from 76 BC patients, 45 whom were paired before after chemotherapy. These patients enrolled CANTO prospective study designed record side effects associated with management BC. We analyzed associations between baseline or post-chemotherapy plasma metabolomics prognosis, as well therapy-induced effects. examined relevance these findings immunocompetent mice colonized patient that subsequently challenged histo-compatible mouse conclude specific gut commensals are overabundant compared healthy individuals negatively modulated by chemotherapy, may influence weight gain neurological therapies. obtained adjuvant neoadjuvant settings warrant validation.

Language: Английский

Citations

127