Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases DOI Creative Commons
Hamid M. Abdolmaleky, Jin‐Rong Zhou

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 985 - 985

Published: Aug. 14, 2024

Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve

Language: Английский

The gut microbiota–brain axis in behaviour and brain disorders DOI
Lívia H. Morais, Henry L. Schreiber, Sarkis K. Mazmanian

et al.

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255

Published: Oct. 22, 2020

Language: Английский

Citations

1472
Gut microbiota-derived metabolites as central regulators in metabolic disorders DOI Creative Commons
Allison Agus, Karine Clément, Harry Sokol

et al.

Gut, Journal Year: 2020, Volume and Issue: 70(6), P. 1174 - 1182

Published: Dec. 3, 2020

Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is crucial actor that can interact with the host by production of diverse reservoir metabolites, from exogenous dietary substrates or endogenous compounds. are associated alterations in composition and function microbiota. Specific classes microbiota-derived notably bile acids, short-chain fatty branched-chain amino trimethylamine N-oxide, tryptophan indole derivatives, have been implicated pathogenesis metabolic disorders. This review aims define key metabolites altered diseases role pathogenesis. They potential biomarkers for early diagnosis prognosis as well promising targets development novel therapeutic tools

Language: Английский

Citations

857
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice DOI Creative Commons

Lingyan Ma,

Yinhua Ni, Zhe Wang

et al.

Gut Microbes, Journal Year: 2020, Volume and Issue: 12(1), P. 1832857 - 1832857

Published: Nov. 5, 2020

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients aging-associated diseases metabolic dysfunction. However, mechanism spermidine on obesity remains unclear. Here, we show intake negatively correlated both humans mice. Spermidine supplementation causes significant loss weight improves insulin resistance diet-induced obese (DIO) These effects are alleviation endotoxemia enhancement function, which might be mediated through pathway TLR4-mediated microbial signaling transduction. Moreover, alteration microbiota composition function. Microbiota depletion compromises while transplantation spermidine-altered confers protection against obesity. changes partly driven by SCFA-producing bacterium, Lachnospiraceae NK4A136 group, was decreased subjects subsequently increased spermidine. Notably, change group significantly enhanced induced Our results indicate may serve viable therapy for

Language: Английский

Citations

398
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments DOI Creative Commons

Rexiati Ruze,

Tiantong Liu,

Xi Zou

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: April 21, 2023

The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing worldwide. Sharing powerful genetic environmental features in their pathogenesis, amplifies the impact susceptibility factors on DM. ectopic expansion adipose tissue excessive accumulation certain nutrients metabolites sabotage metabolic balance via insulin resistance, dysfunctional autophagy, microbiome-gut-brain axis, further exacerbating dysregulation immunometabolism through low-grade systemic inflammation, leading to an accelerated loss functional β-cells gradual elevation blood glucose. Given these intricate connections, most available treatments type 2 DM (T2DM) have a mutual effect each other. For example, anti-obesity drugs can be anti-diabetic some extent, medicines, contrast, shown increase body weight, such as insulin. Meanwhile, surgical procedures, especially bariatric surgery, are more effective for both T2DM. Besides guaranteeing availability accessibility all diagnostic therapeutic tools, clinical experimental investigations pathogenesis two diseases warranted improve efficacy safety newly developed treatments.

Language: Английский

Citations

337
Role of Insulin Resistance in MAFLD DOI Open Access

Yoshitaka Sakurai,

Naoto Kubota, Toshimasa Yamauchi

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 4156 - 4156

Published: April 16, 2021

Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as dysfunction-associated (MAFLD). Metabolic this context encompasses obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and syndrome, with insulin resistance common pathophysiology. Imbalance between energy intake expenditure results various tissues alteration gut microbiota, resulting fat accumulation liver. The role genetics also been revealed hepatic fibrosis. In process liver, intracellular damage well further potentiates inflammation, fibrosis, carcinogenesis. Increased lipogenic substrate supply from other tissues, zonation Irs1, factors, including ER stress, play crucial roles increased de novo lipogenesis MAFLD resistance. Herein, we provide an overview factors contributing systemic local progression MAFLD.

Language: Английский

Citations

288
Gut microbiota markers associated with obesity and overweight in Italian adults DOI Creative Commons
Vanessa Palmas, Silvia Pisanu,

Veronica Madau

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: March 9, 2021

Abstract In the present study, we characterized distinctive signatures of gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both Sardinian origin. Fecal bacterial composition 46 OB (BMI = 36.6 ± 6.0; F/M 40/6) was analyzed compared to that NW subjects 21.6 2.1; 41/5), matched for sex, age smoking status, by using 16S rRNA gene sequencing on MiSeq Illumina platform. The microbial community exhibited a significant decrease in relative abundance several Bacteroidetes taxa (i.e. Flavobacteriaceae, Porphyromonadaceae, Sphingobacteriaceae, Flavobacterium, Rikenella spp ., Pedobacter Parabacteroides spp., Bacteroides spp.) when NW; instead, Firmicutes were significantly increased same (Lachnospiraceae, Gemellaceae, Paenibacillaceae, Streptococcaceae, Thermicanaceae, Gemella , Mitsuokella Streptococcus Acidaminococcus Eubacterium Ruminococcus Megamonas Thermicanus Megasphaera spp. Veillonella . ). Correlation analysis indicated body fatness waist circumference negatively correlated with taxa, while positively fat muscle mass and/or physical activity level. Furthermore, belonging Enterobacteriaceae family, known exhibit endotoxic activity, group NW. results extend our knowledge GM profiles Italian OB, identifying novel linking obesity intestine.

Language: Английский

Citations

278
Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration DOI Creative Commons
Angelika Więckowska‐Gacek, Anna Mietelska‐Porowska, Małgorzata Wydrych

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 70, P. 101397 - 101397

Published: June 30, 2021

An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor Alzheimer's disease (AD) but holistic view interacting processes through which such may contribute to AD pathogenesis missing. We addressed this need extensive analysis published studies investigating effects western (WD) on development humans laboratory animals. reviewed WD-induced systemic alterations comprising metabolic changes, induction obesity adipose tissue inflammation, gut microbiota dysbiosis acceleration low-grade inflammation. Next we provide an overview evidence demonstrating that WD-associated drive impairment blood-brain barrier (BBB) neuroinflammation paralleled by accumulation toxic amyloid. Later these changes are followed dysfunction synaptic transmission, neurodegeneration finally memory cognitive impairment. conclude WD can trigger inflammaging, BBB induced inflammation play central role process. Moreover, concurrence Aβ dyshomeostasis, reciprocal interactions vicious cycle neurodegeneration, contradicts as primary AD. Given 2019 World Health Organization recommended focusing modifiable factors prevention, sequential, complex pathomechanisms initiated WD, lead from peripheral disturbances support future prevention strategies.

Language: Английский

Citations

242
Short-chain fatty acids in diseases DOI Creative Commons
Dan Zhang,

Yong‐Ping Jian,

Yuning Zhang

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Abstract Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in gastrointestinal tract. The absorption SCFAs is mediated substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled 1, which promote cellular metabolism. An increasing number studies have implicated microorganisms crucial executors diet-based microbial influence on host. important fuels for intestinal epithelial cells (IECs) represent a major carbon flux from diet, that decomposed gut microbiota. play vital role multiple molecular biological processes, promoting secretion glucagon-like peptide-1 IECs to inhibit elevation blood glucose, expression G protein-coupled receptors GPR41 GPR43, inhibiting histone deacetylases, participate regulation proliferation, differentiation, function IECs. affect motility, barrier function, host Furthermore, regulatory roles local, intermediate, peripheral metabolisms. Acetate, propionate, butyrate SCFAs, they involved immunity, apoptosis, inflammation, lipid Herein, we review diverse functional this class reflect their ability intestine, metabolic, other diseases.

Language: Английский

Citations

208
Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome DOI
Benoît Chassaing, Charlene Compher,

Brittaney Bonhomme

et al.

Gastroenterology, Journal Year: 2021, Volume and Issue: 162(3), P. 743 - 756

Published: Nov. 11, 2021

Language: Английский

Citations

203
Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection DOI Creative Commons

Shruti Shandilya,

Sandeep Kumar, Niraj Kumar Jha

et al.

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 38, P. 223 - 244

Published: Sept. 17, 2021

Recent research on the implications of gut microbiota brain functions has helped to gather important information relationship between them. Pathogenesis neurological disorders is found be associated with dysregulation gut-brain axis. Some bacteria metabolites are directly increase in reactive oxygen species levels, one most risk factors neurodegeneration. Besides their morbid association, also play a significant role reducing onset these life-threatening disorders.Studies done recent past raises two link and brain: "gut microbiota-oxidative stress-neurodegeneration" microbiota-antioxidant-neuroprotection. This review aims gives deep insight our readers, collective studies done, focusing mediated oxidative stress involved neurodegeneration along focus those showing involvement neuroprotection.This focused three main key concepts. Firstly, mounting evidences from clinical preclinical arenas shows influence resulting dysfunctional processes. Therefore, we describe potential influencing vulnerability stress, budding causative Alzheimer's Parkinson's disease. Secondly, contributing roles been observed attenuating inflammation via its own or by producing secondary and, modulation population antioxidative anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput silico tools databases correlation microbiome, health, thus providing fascinating perspective new avenues for therapeutic options.

Language: Английский

Citations

190