Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

---

Gut microbiome and prostate cancer

International Journal of Urology, Journal Year: 2022, Volume and Issue: 29(8), P. 793 - 798

Published: April 6, 2022

The gut microbiome is linked to several diseases such as Alzheimer's disease, rheumatoid arthritis, and colon cancer. also associated with the modulation of immune function, resulting in a different response checkpoint therapy. differs according lifestyle, diet, sex, race, genetic background, country. Lifestyle, especially plays an important role development progression prostate Recent studies have revealed connection between A high-fat diet causes dysbiosis bacterial metabolites, short-chain fatty acids phospholipids that enter systemic circulation result promoting cancer growth. Additionally, microbiota can serve source testosterone, which affects progression. Men castration-resistant increased abundance bacteria androgenic functions. high-risk share specific microbial profile profiling could be potentially effective tool screen men Lifestyle modifications improve microbiome. Furthermore, altering using prebiotic or probiotic interventions may prevent delay development. Further study into "Gut-Prostate Axis" would help discovery new strategies for prevention, screening, treatment

Language: Английский

---

Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1701 - 1701

Published: June 13, 2023

Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, FM IBS frequently co-exist, which suggests common aetiology for the two diseases. The exact physiopathological mechanisms underlying both onset are unknown. Researchers have investigated possible causes, including alterations in gut microbiota, contain billions microorganisms human digestive tract. gut-brain axis has been proven to be link between microbiota central nervous system, can then control composition. In this review, we will discuss similarities IBS. Particularly, focus our attention on symptomatology overlap as well composition patients. We also briefly potential therapeutic approaches based manipulations that successfully used could employed patients relieve pain, ameliorate rehabilitation outcome, psychological distress symptoms.

Language: Английский

---

Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 2, 2023

Post-cholecystectomy diarrhea (PCD) is highly prevalent among outpatients with cholecystectomy, and gut microbiota alteration correlated it. However, how to what extent changed fecal bacteria contributes are still unrevealed. Humanized microbiome mice model by transplantation was established explore the diarrhea-inducible effects of microbiota. The role microbial bile acids (BAs) metabolites identified UPLC/MS underlying mechanisms were investigated selective inhibitors antagonists as probes. These transplanted PCD patients (PCD mice) exhibited significantly enhanced gastrointestinal motility elevated water content, compared these NonPCD HC. In analyzing microbiota, tryptophan metabolism enriched in microbiome. addition, overabundant serotonin serum colon, along biosynthesis gene reduced reuptake gene, expressed 5-HT receptors (5-HTRs) colon found, but not small intestine. Notably, diarrheal phenotypes depleted hydroxylase 1 inhibitor (LX1606) 5-HTRs (alosetron GR113808). Furthermore, increased secondary BAs DCA, HDCA LCA revealed feces they found responsible for stimulating level vitro vivo. Intriguingly, blocking BAs-conjugated TGR5/TRPA1 signaling pathway could alleviate PCD. conclusion, altered after cholecystectomy promoting which stimulates colonic increases motility.

Language: Английский

---

The influence of microbiota on ferroptosis in intestinal diseases

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Oct. 5, 2023

Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised antioxidant defenses. Multiple metabolic pathways, including iron metabolism, as well systems, contribute to the execution ferroptosis. The gut microbiota exerts regulatory effects ferroptosis through its microbial composition, biological functions, metabolites. Notably, most pathogenic bacteria tend promote ferroptosis, thereby inducing or exacerbating diseases, while probiotics have been shown protect against death. Given colonization in gut, an intimate association found between intestinal diseases microbiota. This review consolidates essential aspects ferroptotic processes, emphasizing key molecules delineating intricate interplay Moreover, this underscores potential utility modulation regulating for treatment diseases.

Language: Английский

---

The Postbiotic Properties of Butyrate in the Modulation of the Gut Microbiota: The Potential of Its Combination with Polyphenols and Dietary Fibers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6971 - 6971

Published: June 26, 2024

The gut microbiota is a diverse bacterial community consisting of approximately 2000 species, predominantly from five phyla: Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia. microbiota's species create distinct compounds that impact the host's health, including well-known short-chain fatty acids. These are produced through breakdown dietary fibers fermentation undigested carbohydrates by intestinal microbiota. main acids consist acetate, propionate, butyrate. concentration butyrate in mammalian intestines varies depending on diet. Its functions use as an energy source, cell differentiation, reduction inflammatory process intestine, defense against oxidative stress. It also plays epigenetic role histone deacetylases, thus helping to reduce risk colon cancer. Finally, affects gut-brain axis crossing brain-blood barrier, making it crucial determine right concentrations for both local peripheral effects. In recent years, there has been significant amount attention given polyphenols promoting human health. Polyphenols play roles protecting health can produce fermentation. This paper aims summarize information key summits related negative correlation between diversity chronic diseases guide future research determining specific activity carry out these vital functions.

Language: Английский

---

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 5, 2024

Increasing evidence links the gut microbiome and nervous system in health disease. This narrative review discusses current views on interaction between microbiota, intestinal epithelium, brain, provides an overview of communication routes signals bidirectional interactions microbiota including circulatory, immunological, neuroanatomical, neuroendocrine pathways. Similarities differences healthy humans mice exist that are relevant for translational gap non-human model systems patients. There is increasing spectrum metabolites neurotransmitters released and/or modulated by both homeostatic pathological conditions. Dysbiotic disruptions occur as consequences critical illnesses such cancer, cardiovascular chronic kidney disease but also neurological, mental, pain disorders, well ischemic traumatic brain injury. Changes (dysbiosis) a concomitant imbalance release mediators may be cause or consequence diseases central increasingly emerging to disruption physiological function, alterations nutrition intake, exposure hypoxic conditions others, observed disorders. Despite generally accepted importance microbiome, not fully understood. Elucidating these signaling pathways more detail offers novel mechanistic insight into pathophysiology multifaceted aspects

Language: Английский

---

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

Abstract Amino acid availability is monitored by animals to adapt their nutritional environment. Beyond gustatory receptors and systemic amino sensors, enteroendocrine cells (EECs) are believed directly percept dietary acids secrete regulatory peptides. However, the cellular machinery underlying acid-sensing EECs how EEC-derived hormones modulate feeding behavior remain elusive. Here, developing tools specifically manipulate EECs, we find that Drosophila neuropeptide F (NPF) from mated female inhibits feeding, similar human PYY. Mechanistically, L-Glutamate acts through metabotropic glutamate receptor mGluR decelerate calcium oscillations in thereby causing reduced NPF secretion via dense-core vesicles. Furthermore, two dopaminergic enteric neurons expressing NPFR perceive relay an anorexigenic signal brain. Thus, our findings provide mechanistic insights into assess food quality identify a conserved mode of action explains gut NPF/PYY modulates intake.

Language: Английский

---

Stress, microbiota, and the gut–brain axis in mental and digestive health

Medicina Clínica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

The gut–organ axis: Clinical aspects and immune mechanisms

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The gut-brain axis exemplifies the bidirectional connection between intestines and brain, as evidenced by impact of severe stress on gastrointestinal symptoms including abdominal pain diarrhea, conversely, influence discomfort mood. Clinical observations support notion connection, an increased prevalence inflammatory bowel disease (IBD) in patients with depression anxiety, well association changes gut microbiota neurological disorders such multiple sclerosis, Parkinson's disease, stroke Alzheimer's disease. brain communicate via complex mechanisms involving cytokines, immune cells, autonomic nerves, microbiota, which contribute to pathogenesis certain diseases. Two primary pathways mediate information exchange intestinal tract brain: signal transduction through bloodstream factors, bacterial metabolites neural pathways, neurotransmitters cytokines within nervous system interaction nerve cells beyond. In recent years, basic pathophysiology have been gradually elucidated. Beyond interaction, emerging evidence suggests extends other organs, liver lungs, intricate inter-organ communication pathways. An increasing number reports this clinical cross-organ interactions underscore potential for better understanding novel therapeutic strategies targeting inter-organs networks. Further clarification multiorgans premises transformative insights into strategies.

Language: Английский

---