Uludağ Üniversitesi Tıp Fakültesi Dergisi,
Journal Year:
2023,
Volume and Issue:
49(3), P. 425 - 438
Published: Nov. 28, 2023
Glutatyon
(GSH)
ve
glutatyon
peroksidaz
4
(Glutathione
peroxidase
4;
GPX4)
gibi
lipid
onarım
sistemleriyle
kontrol
edilen
çoklu
doymamış
yağ
asidi
(polyunsaturated
fatty
acids;
PUFA)
biyosentezini
de
kapsayan,
bir
dizi
enzimatik
reaksiyon
ile
korele
olan
ölüm
tipine
ferroptoz
adı
verilir.
Ferroptoz
aynı
zamanda,
ferröz
(Fe+2)
demire
bağımlı
hücre
tipi
olarak
tanımlanmıştır.
Apoptoz,
piroptoz,
otofaji
diğer
yollarından
farklı
özellikler
gösterir.
sırasında
gözlemlenen
en
önemli
morfolojik
özellikler;
mitokondride
gözlenen
küçülme
membran
yoğunluğudur.
Biyokimyasal
ise,
içi
serbest
demir
miktarındaki
artış
peroksidasyonudur.
Ferroptoz,
nörodejeneratif
hastalıklar
kanser
hastalıkların
ortaya
çıkmasında
gelişiminde
rol
oynaması
nedeniyle
çok
sayıda
araştırmanın
odak
noktası
haline
gelmiştir.
Bu
yanı
sıra;
GPX4,
GSH
aktivitesinde
azalma
ortamda
reaktif
oksijen
türlerinin
(ROT)
birikimi
olaylar
birçok
enfeksiyon
hastalığında
da
süreci
görülebilmektedir.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3694 - 3694
Published: March 26, 2024
Metabolic-associated
fatty
liver
disease
(MAFLD)
includes
several
metabolic
dysfunctions
caused
by
dysregulation
in
the
brain–gut–liver
axis
and,
consequently,
increases
cardiovascular
risks
and
dysfunction.
In
MAFLD,
type
2
diabetes
mellitus,
obesity,
syndrome
are
frequently
present;
these
conditions
related
to
lipogenesis
systemic
inflammation.
This
study
aimed
review
connection
between
MAFLD.
The
inflammatory
process,
cellular
alterations
hepatocytes
stellate
cells,
hypercaloric
diet,
sedentarism
aggravate
prognosis
of
patients
with
Thus,
understand
modulation
physiopathology
it
is
necessary
include
organokines
involved
this
process
(adipokines,
myokines,
osteokines,
hepatokines)
their
clinical
relevance
project
future
perspectives
condition
bring
light
new
possibilities
therapeutic
approaches.
Adipokines
responsible
for
activation
distinct
signaling
different
tissues,
such
as
insulin
pro-inflammatory
cytokines,
which
important
balancing
substances
avoid
MAFLD
its
progression.
Myokines
improve
quantity
quality
adipose
contributing
avoiding
development
Finally,
hepatokines
decisive
improving
or
not
progression
through
regulation
anti-inflammatory
organokines.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116777 - 116777
Published: May 24, 2024
Neuroimmune
and
neurodegenerative
ailments
impose
a
substantial
societal
burden.
disorders
involve
the
intricate
regulatory
interactions
between
immune
system
central
nervous
system.
Prominent
examples
of
neuroimmune
encompass
multiple
sclerosis
neuromyelitis
optica.
Neurodegenerative
diseases
result
from
neuronal
degeneration
or
demyelination
in
brain
spinal
cord,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis.
The
precise
underlying
pathogenesis
these
conditions
remains
incompletely
understood.
Ferroptosis,
programmed
form
cell
death
characterised
by
lipid
peroxidation
iron
overload,
plays
pivotal
role
diseases.
In
this
review,
we
provide
detailed
overview
ferroptosis,
its
mechanisms,
pathways,
regulation
during
progression
Furthermore,
summarise
impact
ferroptosis
on
neuroimmune-related
cells
(T
cells,
B
neutrophils,
macrophages)
neural
(glial
neurons).
Finally,
explore
potential
therapeutic
implications
inhibitors
diverse
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
324, P. 117787 - 117787
Published: Jan. 21, 2024
Ulcerative
colitis
(UC)
is
a
chronic
idiopathic
intestinal
disease
of
unknown
cause
and
has
been
classified
as
one
the
modern
intractable
diseases
by
World
Health
Organization
(WHO).
Ferroptosis,
an
iron-ion-dependent
mode
programmed
cell
death,
closely
related
to
iron
metabolism,
lipid
peroxidation,
imbalance
antioxidant
system,
plays
important
role
in
development
UC.
In
this
paper,
we
will
review
regulatory
pathways
ferroptosis,
relationship
between
ferroptosis
pathogenesis
UC,
treatment
UC
TCM
from
perspective
inhibition,
summarize
mechanism
action
active
ingredients
compounds
improve
through
look
forward
prospect
application
inhibition
This
paper
aims
elucidate
combinations
inhibiting
ferroptosis.
The
have
significant
advantages
multi-targets
multi-pathways,
current
research
hotspot
prevention
so
key
direction
for
future
research.
keywords
"ferroptosis",
"ulcerative
colitis"
"TCM"
were
searched
Pubmed,
CNKI,
Wed
Science
databases.
Papers
clinical
trials
pharmacological
up
August
2023
screened
inclusion.
Combined
with
theory
TCM,
systematically
summarized
effects
thus
preventing
A
large
number
studies
shown
that
inhibit
inflammatory
response
oxidative
stress
course
mainly
interfering
correcting
metabolism
peroxidative
accumulation,
regulating
processes
glutathione
(GSH)
peroxidase
4
(GPX4),
colonic
mucosal
damage
promote
repair
tissue.
Since
study
still
exploratory
stage,
many
issues
deserve
attention
future.
reviews
prevent
treat
future,
should
also
further
increase
experimental
explore
whether
more
medicines
can
play
therapeutic
genes
targeting
seek
therapies
We
believe
use
regulate
treatment.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 56 - 56
Published: Jan. 6, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
prevalent
chronic
condition
marked
by
excessive
lipid
accumulation
in
hepatic
tissue.
This
disorder
can
lead
to
range
of
pathological
outcomes,
including
metabolic
steatohepatitis
(MASH)
and
cirrhosis.
Despite
extensive
research,
the
molecular
mechanisms
driving
MASLD
initiation
progression
remain
incompletely
understood.
Oxidative
stress
peroxidation
are
pivotal
"multiple
parallel
hit
model",
contributing
cell
death
tissue
damage.
Gut
microbiota
plays
substantial
role
modulating
oxidative
through
multiple
pathways:
impairing
intestinal
barrier,
which
results
bacterial
translocation
inflammation;
modifying
bile
acid
structure,
impacts
signaling
cascades
involved
lipidic
metabolism;
influencing
hepatocytes'
ferroptosis,
form
programmed
death;
regulating
trimethylamine
N-oxide
(TMAO)
activating
platelet
function,
both
recently
identified
as
pathogenetic
factors
MASH
progression.
Moreover,
various
exogenous
impact
gut
its
involvement
MASLD-related
stress,
such
air
pollution,
physical
activity,
cigarette
smoke,
alcohol,
dietary
patterns.
manuscript
aims
provide
state-of-the-art
overview
focused
on
intricate
interplay
between
microbiota,
peroxidation,
pathogenesis,
offering
insights
into
potential
strategies
prevent
associated
complications.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(12)
Published: Nov. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: May 15, 2024
Abstract
Ferroptosis
is
a
novel
form
of
lipid
peroxidation-driven,
iron-dependent
programmed
cell
death.
Various
metabolic
pathways,
including
those
involved
in
and
iron
metabolism,
contribute
to
ferroptosis
regulation.
The
gut
microbiota
not
only
supplies
nutrients
energy
the
host,
but
also
plays
crucial
role
immune
modulation
balance.
In
this
review,
we
explore
pathways
associated
with
impact
on
host
metabolism.
We
subsequently
summarize
recent
studies
influence
regulation
by
discuss
potential
mechanisms
through
which
affects
ferroptosis.
Additionally,
conduct
bibliometric
analysis
relationship
between
context
chronic
kidney
disease.
This
can
provide
new
insights
into
current
research
status
future
microbiota.
