Seminars in Liver Disease,
Journal Year:
2022,
Volume and Issue:
42(02), P. 113 - 121
Published: March 9, 2022
Circadian
rhythms
are
approximately
24-hour
cycles
of
variation
in
physiological
processes,
gene
expression,
and
behavior.
They
result
from
the
interplay
internal
biological
clocks
with
daily
environmental
rhythms,
including
light/dark
feeding/fasting.
Note
that
liver
metabolic
processes
have
been
known
for
almost
100
years.
Modern
studies
reveal
that,
like
metabolism,
hepatic
expression
is
highly
rhythmic.
Genetic
or
changes
can
disrupt
circadian
liver,
leading
to
disorders
hepatocellular
carcinoma.
In
this
review,
we
summarize
current
understanding
mechanisms
regulating
rhythmic
highlighting
roles
transcription
factors
comprise
core
clock
molecular
as
well
noncanonical
regulators.
We
emphasize
plasticity
it
responds
multiple
inputs
external
environments
potential
medicine
impact
liver-related
diseases.
Science Immunology,
Journal Year:
2022,
Volume and Issue:
7(72)
Published: June 3, 2022
The
immune
system
is
highly
time-of-day
dependent.
Pioneering
studies
in
the
1960s
were
first
to
identify
responses
be
under
a
circadian
control.
Only
last
decade,
however,
have
molecular
factors
governing
rhythms
been
identified.
These
revealed
complex
picture
of
interconnectivity
rhythmicity
within
cells
with
that
their
environment.
Here,
we
provide
global
overview
system,
focusing
on
recent
advances
rapidly
expanding
field
immunology.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(24), P. 5196 - 5196
Published: Dec. 7, 2022
Research
shows
that
reduced
sleep
duration
is
related
to
an
increased
risk
of
obesity.
The
relationship
between
deprivation
and
obesity,
type
2
diabetes,
other
chronic
diseases
may
be
the
imbalance
appetite
regulation.
To
comprehensively
illustrate
specific
regulation,
this
review
introduces
pathophysiology
deprivation,
research
cutting
edge
animal
models,
central
regulatory
mechanism
under
deprivation.
This
paper
summarizes
changes
in
appetite-related
hormones
orexin,
ghrelin,
leptin,
insulin
secretion
caused
by
long-term
based
on
epidemiology
data
studies
have
established
models.
Moreover,
analyzes
potential
associations
regulation
providing
more
clues
further
new
strategies
access
obesity
metabolic
disease.
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(6), P. 112588 - 112588
Published: June 1, 2023
Physiology
is
regulated
by
interconnected
cell
and
tissue
circadian
clocks.
Disruption
of
the
rhythms
generated
concerted
activity
these
clocks
associated
with
metabolic
disease.
Here
we
tested
interactions
between
in
two
critical
components
organismal
metabolism,
liver
skeletal
muscle,
rescuing
clock
function
either
each
organ
separately
or
both
organs
simultaneously
otherwise
clock-less
mice.
Experiments
showed
that
individual
are
partially
sufficient
for
glucose
yet
connections
coupled
to
daily
feeding
support
systemic
tolerance.
This
synergy
relies
part
on
local
transcriptional
control
machinery,
feeding-responsive
signals
such
as
insulin,
cycles
connect
muscle
liver.
We
posit
spatiotemporal
mechanisms
play
an
essential
role
maintenance
homeostasis
disrupting
this
diurnal
coordination
can
contribute
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 11, 2023
The
biological
clock
system
is
an
intrinsic
timekeeping
device
that
integrates
internal
physiology
and
external
cues.
Maintaining
a
healthy
crucial
for
life.
Disruptions
to
the
body’s
can
lead
disturbances
in
sleep-wake
cycle
abnormalities
hormone
regulation,
blood
pressure,
heart
rate,
other
vital
processes.
Long-term
have
been
linked
development
of
various
common
major
diseases,
including
cardiovascular
metabolic
disorders,
tumors,
neuropsychiatric
conditions,
so
on.
External
factors,
such
as
diurnal
rhythm
light,
significant
impact
on
clock.
Additionally,
important
non-photic
zeitgeber,
exercise
regulate
rhythms
certain
extent,
making
it
possible
become
non-drug
intervention
preventing
treating
circadian
disorders.
This
comprehensive
review
encompasses
behavioral,
physiological,
molecular
perspectives
provide
deeper
understanding
how
influences
its
association
with
related
diseases.
Endocrinology,
Journal Year:
2023,
Volume and Issue:
164(6)
Published: April 17, 2023
REV-ERB
nuclear
receptors
are
potent
transcriptional
repressors
that
play
an
important
role
in
the
core
mammalian
molecular
clock
and
metabolism.
Deletion
of
both
REV-ERBα
its
largely
redundant
isoform
REV-ERBβ
a
murine
tissue-specific
manner
have
shed
light
on
their
specific
functions
mechanisms
circadian
This
review
highlights
recent
findings
establish
REV-ERBs
as
crucial
timekeepers
variety
tissues,
regulating
overlapping
distinct
processes
maintain
normal
physiology
protect
from
metabolic
dysfunction.
Science,
Journal Year:
2024,
Volume and Issue:
386(6722), P. 673 - 677
Published: Nov. 7, 2024
Circadian
desynchrony
induced
by
shiftwork
or
jet
lag
is
detrimental
to
metabolic
health,
but
how
synchronous
desynchronous
signals
are
transmitted
among
tissues
unknown.
We
report
that
liver
molecular
clock
dysfunction
signaled
the
brain
through
hepatic
vagal
afferent
nerve
(HVAN),
leading
altered
food
intake
patterns
corrected
ablation
of
HVAN.
Hepatic
branch
vagotomy
also
prevents
disruptions
high-fat
diet
feeding
and
reduces
body
weight
gain.
Our
findings
reveal
a
homeostatic
feedback
signal
relies
on
communication
between
control
circadian
patterns.
This
identifies
vagus
as
potential
therapeutic
target
for
obesity
in
setting
chronodisruption.
