Research Advances of Catheter Ablation Improving Renal Function Impairment in Patients with Atrial Fibrillation DOI

小玲 陈

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(09), P. 758 - 764

Published: Jan. 1, 2024

Language: Английский

Cellular and molecular cross‐talk in atrial fibrillation: The role of non‐cardiomyocytes in creating an arrhythmogenic substrate DOI Creative Commons
Zhenyu Dong, Ruben Coronel, Joris R. de Groot

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Atrial fibrillation (AF) is a complex arrhythmia. Various modulating factors influence its triggers and substrate. Fibroblasts, adipocytes, inflammatory cells the coagulation system can disrupt cardiomyocyte function. Cardiomyocytes fibroblasts release cytokines that promote local systemic inflammation, enhancing fibroblast activation extracellular matrix deposition, leading to myocardial fibrosis. Fibrosis essential for induction of reentrant arrhythmias, including AF. Adipocytes contribute arrhythmogenesis by secreting pro-inflammatory pro-fibrotic factors, exacerbating inflammation metabolic dysregulation. Inflammatory mediators activate system, which augments this vicious cycle producing promoting fibrosis arrhythmias at same time as increasing risk thrombosis. Understanding these interconnected roles in development progress atrial arrhythmogenic substrate may point potential novel therapeutic targets stabilise or antagonise eventually prevent This review examines role interplay between cardiomyocytes, fibroblasts, contributing AF initiation perpetuation.

Language: Английский

Citations

0
Nonatherosclerotic Cardiovascular Disease in Chronic Kidney Disease DOI

Nishigandha Pradhan,

Mirela Dobre

Cardiology Clinics, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID) DOI Creative Commons

Attila Kállai,

Anna Ungvari,

Dóra Csabán

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome DOI Creative Commons
Jia Song, Jiao Wu, Dexter Robichaux

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 108 - 108

Published: Jan. 5, 2024

High-protein diets (HPDs) offer health benefits, such as weight management and improved metabolic profiles. The effects of HPD on cardiac arrhythmogenesis remain unclear. Atrial fibrillation (AF), the most common arrhythmia, is associated with inflammasome activation. role Absent-in-Melanoma 2 (AIM2) in AF pathogenesis remains unexplored. In this study, we discovered that increased susceptibility to AF. To demonstrate involvement AIM2 signaling HPD-induced AF, wildtype (WT) Aim2−/− mice were fed normal-chow (NC) HPD, respectively. Four weeks later, activity was upregulated atria WT-HPD mice, but not Aim2−/−-HPD mice. vulnerability abnormal sarcoplasmic reticulum (SR) Ca2+-release events atrial myocytes. cytoplasmic double-strand (ds) DNA level, causing Genetic inhibition reduced dsDNA mitochondrial ROS production, SR These data suggest creates a substrate conducive development by activating AIM2-inflammasome, which oxidative stress along proarrhythmic Ca2+-release. Our imply targeting might constitute novel anti-AF strategy certain patient subpopulations.

Language: Английский

Citations

3
Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation DOI Creative Commons

Alisha Niskala,

Jordi Heijman, Dobromir Dobrev

et al.

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 15, 2024

Abstract Inflammatory signalling via the nod‐like receptor (NLR) family pyrin domain‐containing protein‐3 (NLRP3) inflammasome has recently been implicated in pathophysiology of atrial fibrillation (AF). However, precise role NLRP3 various cardiac cell types is poorly understood. Targeting components or products and preventing their proinflammatory consequences may constitute novel therapeutic treatment strategies for AF. In this review, we summarise current understanding AF pathogenesis. We first review pathway inflammatory cardiomyocytes, (myo)fibroblasts immune cells, such as neutrophils, macrophages monocytes. Because numerous compounds targeting are currently preclinical development, undergoing clinical evaluation other indications than AF, subsequently known therapeutics, colchicine canakinumab, evaluate potential treating

Language: Английский

Citations

3
Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-IbΔC-X mice with persistent atrial fibrillation DOI
Shuai Zhao, Mohit Hulsurkar, Satadru K. Lahiri

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: 190, P. 1 - 12

Published: March 19, 2024

Language: Английский

Citations

2
Inflammasome activation: unraveling the link between chronic kidney disease and atrial fibrillation DOI
Melis Sahinoz, T. Alp İkizler

Kidney International, Journal Year: 2024, Volume and Issue: 106(1), P. 6 - 9

Published: June 19, 2024

Language: Английский

Citations

2
ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome DOI

Zihan Chen,

Zaihua Cheng,

Congcong Ding

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Language: Английский

Citations

4
Association between changes in renal function and clinical outcomes in anticoagulated atrial fibrillation patients with marginal renal function. A nationwide observational cohort study DOI Creative Commons
Kyung-Yeon Lee, So‐Ryoung Lee, Eue‐Keun Choi

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 6, 2024

Background Renal function is one of the crucial components for determining dose and type oral anticoagulants in atrial fibrillation (AF) patients, also closely associated with risks stroke bleeding. This study aimed to assess renal changes their impact on clinical outcomes anticoagulated AF patients marginal function. Methods From a Korean claims database, baseline eGFR 45 <60 ml/min/1.73 m 2 were studied. Patients grouped by over two years—maintained, improved (eGFR >60 ), or worsened <45 )—the analyzed including ischemic stroke, major bleeding, end-stage disease (ESRD), all-cause death, composite outcomes. Results A total 5,126 included study: 2,170 (42.3%) maintained group, 2,276 (44.4%) 680 (13.1%) group The was older had more prevalent comorbidities than other groups. After multivariable adjustment, significantly higher bleeding (adjusted hazard ratio, 95% confidence interval; 1.46, 1.03–2.07, p = 0.035), ESRD (1.49, 1.24–1.80, < 0.001), death (9.29, 4.92–17.6, outcome (1.57, 1.36–1.83, 0.001). Conclusions In function, substantial proportion experienced decline below within years. ESRD, compared those who

Language: Английский

Citations

1
Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys DOI
Aiguo Zhang, Xuefei Wang, Mingming Fan

et al.

Toxicon, Journal Year: 2024, Volume and Issue: 249, P. 108078 - 108078

Published: Aug. 23, 2024

Language: Английский

Citations

1