Synaptic Mechanisms Regulating Mood State Transitions in Depression DOI Open Access
Puja K. Parekh, Shane B. Johnson, Conor Liston

et al.

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 581 - 601

Published: May 4, 2022

Depression is an episodic form of mental illness characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects stress and depression on synapse function, enhancing neurotransmission, increasing plasticity, generating new synapses in stress-sensitive brain regions. These properties are shared to varying degrees all known antidepressants, suggesting that synaptic remodeling could play a key role pathophysiology antidepressant function. Still, it unclear whether precisely how synaptogenesis contributes transitions. Here, we review evidence supporting emerging model which defined distinct distributed across multiple circuits, neurons assuming altered functional properties, configurations, and, importantly, reduced capacity for plasticity adaptation. act initially facilitating enabling reconfiguration this state. Subsequently, plays specific sustaining these changes over time.

Language: Английский

Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial DOI
Eleanor Cole, Angela Phillips, Brandon S. Bentzley

et al.

American Journal of Psychiatry, Journal Year: 2021, Volume and Issue: 179(2), P. 132 - 141

Published: Oct. 29, 2021

Depression is the leading cause of disability worldwide, and half patients with depression have treatment-resistant depression. Intermittent theta-burst stimulation (iTBS) approved by U.S. Food Drug Administration for treatment but limited suboptimal efficacy a 6-week duration. The authors addressed these limitations developing neuroscience-informed accelerated iTBS protocol, Stanford neuromodulation therapy (SNT; previously referred to as intelligent therapy, or SAINT). This protocol was associated remission rate ∼90% after 5 days open-label treatment. Here, report results sham-controlled double-blind trial SNT depression.Participants currently experiencing moderate severe depressive episodes were randomly assigned receive active sham SNT. Resting-state functional MRI used individually target region left dorsolateral prefrontal cortex most functionally anticorrelated subgenual anterior cingulate cortex. primary outcome score on Montgomery-Åsberg Rating Scale (MADRS) 4 weeks treatment.At planned interim analysis, 32 participants had been enrolled, 29 who continued meet inclusion criteria received either (N=14) (N=15) mean percent reduction from baseline in MADRS 52.5% group 11.1% group.SNT, high-dose functional-connectivity-guided targeting, more effective than Further trials are needed determine SNT's durability compare it other treatments.

Language: Английский

Citations

492
Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression DOI Open Access
Robin Cash, Anne Weigand, Andrew Zalesky

et al.

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 90(10), P. 689 - 700

Published: June 7, 2020

Language: Английский

Citations

263
Causal mapping of human brain function DOI
Shan Siddiqi, Konrad P. Körding, Josef Parvizi

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(6), P. 361 - 375

Published: April 20, 2022

Language: Английский

Citations

223
Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease DOI
Shan Siddiqi, Frédéric Schaper, Andreas Horn

et al.

Nature Human Behaviour, Journal Year: 2021, Volume and Issue: 5(12), P. 1707 - 1716

Published: July 8, 2021

Language: Английский

Citations

181
Opportunities of connectomic neuromodulation DOI Creative Commons
Andreas Horn, Michael Fox

NeuroImage, Journal Year: 2020, Volume and Issue: 221, P. 117180 - 117180

Published: July 20, 2020

The process of altering neural activity – neuromodulation has long been used to treat patients with brain disorders and answer scientific questions. Deep stimulation in particular provided clinical benefit over 150,000 patients. However, our understanding how impacts the is evolving. Instead focusing on local impact at site itself, we are considering remote regions connected site. Brain connectivity information derived from advanced magnetic resonance imaging data can be identify these connections better understand behavioral effects neuromodulation. In this article, review studies combining connectomics, highlighting opportunities where approach may prove particularly valuable. We focus deep stimulation, but show that same principles applied other forms neuromodulation, such as transcranial MRI-guided focused ultrasound. outline future perspectives provide testable hypotheses for work.

Language: Английский

Citations

155
Personalized connectivity‐guided DLPFC‐TMS for depression: Advancing computational feasibility, precision and reproducibility DOI
Robin Cash, Luca Cocchi, Jinglei Lv

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 42(13), P. 4155 - 4172

Published: Feb. 5, 2021

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory depression, however, therapeutic outcomes vary. Mounting evidence suggests that clinical response relates to functional connectivity with subgenual cingulate (SGC) at precise DLPFC site. Critically, SGC-related network architecture shows considerable interindividual variation across spatial extent DLPFC, indicating connectivity-based target personalization could potentially be necessary improve outcomes. However, date accurate has not appeared feasible, recent work intraindividual reproducibility optimal targets limited 3.5 cm. Here we developed reliable and methodologies compute individualized connectivity-guided targets. In resting-state MRI scans acquired 1,000 healthy adults, demonstrate that, using this approach, personalized can reliably robustly pinpointed, a median accuracy ~2 mm between repeated separate days. These remained highly stable, even after 1 year, distance coordinates only 2.7 mm. Interindividual in exceeded by factor up 6.85, suggesting did trivially converge group-average Moreover, were heritable, rTMS stable over time under genetic control. This computational framework provides capacity TMS computed high precision flexibly advance research other basic applications.

Language: Английский

Citations

125
Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation DOI Creative Commons
Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg

et al.

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 191 - 208

Published: Oct. 5, 2022

Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain based on electromagnetic induction where fluctuating field induces small intracranial electric current in the brain. For more than 35 years, TMS has shown promise diagnosis and treatment of neurological psychiatric disorders adults. In this review, we provide brief introduction to with focus repetitive (rTMS) protocols, particularly theta-burst (TBS), relevant rTMS-derived metrics plasticity. We then discuss TMS-EEG technique, use neuronavigation TMS, neural substrate TBS measures plasticity, inter- intraindividual variability those measures, effects age genetic factors aftereffects, summarize alterations TMS-TBS plasticity major including autism spectrum disorder, schizophrenia, depression, traumatic injury, Alzheimer's disease, diabetes. Finally, translational studies their therapeutic implications.

Language: Английский

Citations

124
New and emerging approaches to treat psychiatric disorders DOI
Katherine W. Scangos, Matthew W. State, Andrew H. Miller

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(2), P. 317 - 333

Published: Feb. 1, 2023

Language: Английский

Citations

74
Functional Connectivity Mapping for rTMS Target Selection in Depression DOI
Immanuel Elbau, Charles J. Lynch, Jonathan Downar

et al.

American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(3), P. 230 - 240

Published: March 1, 2023

Objective: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize treatment targets. However, the efficacy of this approach is unclear, with conflicting findings and varying effect sizes across studies. Here, authors investigated site’s sgACC (sgACC-StimFC) on outcome rTMS in 295 patients major depression. Methods: The reliability accuracy estimating were validated data from individuals who underwent extensive MRI testing. Electric field modeling was used analyze associations between sgACC-StimFC clinical improvement using standardized assessments evaluate sources heterogeneity. Results: An imputation-based method provided reliable accurate estimates. Treatment responses weakly but robustly correlated (r=−0.16), only when stimulated identified electric modeling. Surprisingly, association driven by strong global signal fluctuations stemming a specific periodic respiratory pattern (r=−0.49). Conclusions: Functional individual differences outcomes, weaker than those observed previous studies accentuated subgroup distinct, respiration-related patterns their scans. These indicate that large representative sample depressive disorder, explained ∼3% variance which may limit utility existing sgACC-based targeting protocols. these also provide evidence for true—albeit small—effect highlight opportunities incorporating additional measures generate models response enhanced predictive power.

Language: Английский

Citations

70
A systematic review and meta-analysis of neuromodulation therapies for substance use disorders DOI Creative Commons

Dhvani Mehta,

Angela Praecht,

Heather Burrell Ward

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(4), P. 649 - 680

Published: Dec. 12, 2023

Abstract While pharmacological, behavioral and psychosocial treatments are available for substance use disorders (SUDs), they not always effective or well-tolerated. Neuromodulation (NM) methods, including repetitive transcranial magnetic stimulation (rTMS), direct current (tDCS) deep brain (DBS) may address SUDs by targeting addiction neurocircuitry. We evaluated the efficacy of NM to improve outcomes in SUDs. A systematic literature search was performed on MEDLINE, PsychINFO, PubMed databases a list terms four key concepts (SUD, rTMS, tDCS, DBS) applied. Ninety-four studies were identified that examined effects DBS (e.g., craving, consumption, relapse) amongst individuals with alcohol, tobacco, cannabis, stimulants, opioids. Meta-analyses alcohol tobacco using rTMS tDCS. found reduced as indicated medium large effect sizes (Hedge’s g > 0.5). Results most encouraging when multiple sessions applied, left dorsolateral prefrontal cortex (DLPFC) targeted. tDCS also produced drug though highly variable less robust than rTMS; right anodal DLPFC appeared be efficacious. typically small, uncontrolled studies, but showed promise reducing misuse substances. promising treatment Future should determine underlying neural mechanisms NM, further evaluate extended durations, accelerated administration protocols long-term biochemical verification use.

Language: Английский

Citations

53