Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

Progress in Neurobiology, Journal Year: 2018, Volume and Issue: 175, P. 1 - 19

Published: Dec. 24, 2018

The developing brain is sensitive to a variety of insults. Epidemiological studies have identified prenatal exposure infection as risk factor for range neurological disorders, including autism spectrum disorder and schizophrenia. Animal models corroborate this association been used probe the contribution gene-environment interactions etiology neurodevelopmental disorders. Here we review behavior phenotypes that characterized in MIA offspring, looked at interaction between maternal immune activation genetic factors or These include behaviors relevant autism, schizophrenia, other alterations anatomy, structural functional neuronal impairments. link these phenotypic changes not fully understood, but there increasing evidence induces prolonged offspring's which could underlie epigenetic turn may mediate changes. concepts will be discussed followed by summary pharmacological interventions tested model.

Language: Английский

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Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Nov. 22, 2019

In addition to its role in calcium homeostasis and bone formation, a modulatory of the active form vitamin D on cells immune system, particularly T lymphocytes, has been described. The effects production action several cytokines intensively investigated recent years. this connection, deficiency associated with autoimmune diseases, including type I diabetes mellitus (T1DM), multiple sclerosis (MS), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA). successful pregnancy, maternal response needs adapt accommodate semiallogeneic fetus. Disturbances tolerance are implicated infertility pregnancy complications such as miscarriages (RM) preeclampsia (PE). It is well known that subset regulatory (Tregs) exhibit potent suppressive activity have crucial curtailing destructive system during preventing diseases. Interestingly, common pregnant women, despite widespread use prenatal vitamins, adverse outcomes RM, PE, low birth weight linked levels pregnancy. Research shown diseases significant prevalence within female population, women disorders at higher risk for outcomes. Provocatively, dysregulation plays pathogenesis autoimmunity where these pathologies also D. This article reviews immunomodulatory particular, we will describe from conception until delivery, offspring neurodevelopment. review discuss an observational study which were measured antiphospholipid syndrome, frequently

Language: Английский

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Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: June 22, 2021

Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions with the genome epigenome over generations. While there have been clear successes in large-scale human genetic studies recent decades, is still a substantial amount of missing heritability to be elucidated for complex childhood disorders. Mounting evidence, primarily animals, suggests environmental exposures generate perpetuate altered across one more One putative mechanism these effects epigenetic regulation. This review highlights current epidemiologic literature supporting animal describe intergenerational transgenerational exposures. Both maternal paternal transmission patterns considered, attention paid attendant ethical, legal social implications.

Language: Английский

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The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer

Gene, Journal Year: 2018, Volume and Issue: 647, P. 235 - 243

Published: Jan. 6, 2018

Language: Английский

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Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 117, P. 253 - 278

Published: July 4, 2018

Language: Английский

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A Life History Approach to the Female Sexual Orientation Spectrum: Evolution, Development, Causal Mechanisms, and Health

Archives of Sexual Behavior, Journal Year: 2018, Volume and Issue: 48(5), P. 1273 - 1308

Published: Sept. 18, 2018

Language: Английский

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Micronutrients and Brain Development

Current Nutrition Reports, Journal Year: 2019, Volume and Issue: 8(2), P. 99 - 107

Published: April 5, 2019

Language: Английский

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Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

Food Chemistry Molecular Sciences, Journal Year: 2022, Volume and Issue: 6, P. 100155 - 100155

Published: Dec. 13, 2022

Chronic Non-Communicable Diseases (NCDs) have been considered a global health problem, characterized as diseases of multiple factors, which are developed throughout life, and regardless genetics risk factor important relevance, the increase in mortality attributed to disease environmental factors lifestyle one leads. Although reactive species (ROS/RNS) necessary for several physiological processes, their overproduction is directly related pathogenesis aggravation NCDs. In contrast, dietary polyphenols widely associated with minimizing oxidative stress inflammation. addition antioxidant power, also drawn attention being able modulate both gene expression modify epigenetic alterations, suggesting an essential involvement prevention and/or development some pathologies. Therefore, this review briefly explained mechanisms NCDs, followed by summary evidence interaction stress, well modulation involved management

Language: Английский

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Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort

Neurotoxicology and Teratology, Journal Year: 2023, Volume and Issue: 98, P. 107181 - 107181

Published: May 11, 2023

Exposure to perfluoroalkyl substances (PFAS) has been shown be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure child neurodevelopment is equivocal and scarce.

Language: Английский

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Epigenetic mechanisms underlying sex differences in the brain and behavior

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(1), P. 18 - 35

Published: Nov. 15, 2023

Sex differences are found across brain regions, behaviors, and diseases. Sexual differentiation of the is initiated prenatally but it continues throughout life, as a result interaction three major factors: gonadal hormones, sex chromosomes, environment. These factors thought to act, in part, via epigenetic mechanisms which control chromatin transcriptional states cells. In this review, we discuss evidence that underlie sex-specific neurobehavioral changes during critical organizational periods, estrous cycle, response diverse environments life. We further identify future directions for field will provide novel mechanistic insights into differences, inform disease treatments women's health particular, apply people genders.

Language: Английский

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