RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

Cell & Bioscience, Journal Year: 2020, Volume and Issue: 10(1)

Published: April 1, 2020

Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism angiogenesis. Compared with those other pathways, components PI3K/AKT/mTOR are complicated. regulatory mechanisms functions many human diseases, including ischaemic brain injury, neurodegenerative tumours. inhibitors include single-component dual inhibitors. Numerous PI3K have exhibited good results preclinical studies, some been clinically tested haematologic malignancies solid In this review, we briefly summarize research on discuss structural composition, activation, communication processes, pathogenesis diseases

Language: Английский

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Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2017, Volume and Issue: 55(7), P. 6076 - 6093

Published: Nov. 23, 2017

Language: Английский

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The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

Neurotoxicity Research, Journal Year: 2019, Volume and Issue: 35(3), P. 775 - 795

Published: Feb. 1, 2019

Language: Английский

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PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: April 15, 2021

Alzheimer’s disease (AD) and Parkinson’s (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, health problem economic burden caused by also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction biological processes such as cell proliferation, apoptosis metabolism. According to reports, it neurotoxicity mediates survival neurons through different substrates forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), caspase-9. Accumulating evidences indicate some natural products can play a neuroprotective role activating PI3K/AKT pathway, providing an effective resource for discovery potential therapeutic drugs. This article reviews relationship between AKT AD PD, discusses based on treat in recent years, hoping provide guidance reference this field. Further development Chinese herbal medicine is needed these diseases.

Language: Английский

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Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Genome Medicine, Journal Year: 2016, Volume and Issue: 8(1)

Published: Oct. 12, 2016

Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical genomic studies, molecular basis AD development progression remains elusive. To elucidate systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain samples across 19 cortical regions 125 individuals severity spectrum dementia neuropathology AD. We excluded specimens that evidenced other than characteristic For first time, performed pan-cortical region analysis, characterizing changes measure multiple measures neuropathological lesions (neuritic plaques neurofibrillary tangles) constructing region-specific co-expression networks. rank-ordered 44,692 probesets, 1558 co-expressed modules based upon their association traits. The neurobiological pathways identified through these analyses included actin cytoskeleton, axon guidance, nervous system development. Using public human single-cell RNA-sequencing data, computed cell type-specific marker genes for determined many abnormally expressed signatures network were specific to oligodendrocytes, astrocytes, neurons. Analysis on suggested that: changes, including those occurred early in disease, making them potential translational/treatment targets unlikely be mere bystander result degeneration; several closely linked compromise lesser traditional neuropathology. regional temporal lobe gyri as sites greatest earliest abnormalities. This transcriptomic analysis provides comprehensive assessment critical pathology offers new insights into mechanisms underlying selective vulnerability at different stages canonical

Language: Английский

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Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

Molecular Neurobiology, Journal Year: 2016, Volume and Issue: 54(8), P. 5815 - 5828

Published: Sept. 22, 2016

Language: Английский

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Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(7-8), P. 943 - 957

Published: April 26, 2023

Language: Английский

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Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2021, Volume and Issue: 59(1), P. 354 - 385

Published: Oct. 26, 2021

Language: Английский

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Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

Genes, Journal Year: 2023, Volume and Issue: 14(2), P. 272 - 272

Published: Jan. 20, 2023

The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration the epithelial-mesenchymal transition. Mechanical determined to a large extent by cytoskeleton. cytoskeleton is complex dynamic network composed microfilaments, intermediate filaments microtubules. These cellular structures confer both shape properties. architecture networks formed regulated several pathways, key one being Rho-kinase/ROCK signaling pathway. This review describes role ROCK (Rho-associated coiled-coil forming kinase) how it mediates effects on components that critical for behaviour.

Language: Английский

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PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107300 - 107300

Published: July 9, 2024

Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.

Language: Английский

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