Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Higher intake of dietary folate, especially natural coupled with a lower consumption folic acid supplements, was found to be associated biological age indicators.
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102235 - 102235
Published: Feb. 16, 2024
Language: Английский
Citations
12
Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 22, 2025
Language: Английский
Citations
1
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 12, 2025
Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types offer strong regenerative potential, making them promising for treating various diseases. However, issues with immune response survival limit effectiveness transplantation. This has led increased interest in cell-free therapy, particularly use exosomes, which is most studied form this approach. Exosomes are extracellular vesicles that contain proteins, lipids, nucleic acids play key role communication material exchange. Pyroptosis, death involved innate immunity, also associated many Studies have shown MSC-derived exosomes therapeutic potential range conditions by regulating inflammation pyroptosis. study explored modulating pyroptosis improve bone-related
Language: Английский
Citations
1
Science Advances, Journal Year: 2025, Volume and Issue: 11(11)
Published: March 14, 2025
Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) release inflammatory degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics, o -vanillin RG-7112, remove SnCs in human intervertebral discs (IVDs) reduce SASP release, but it is unknown whether they can treat LBP. sparc −/− mice, with LBP, were treated orally RG-7112 single or combination treatments. Treatment reduced LBP factor removed from IVD spinal cord. also lowered degeneration scores IVDs, improved vertebral bone quality, expression markers Together, our data suggest potential disease-modifying drugs for other painful disorders linked cell senescence.
Language: Английский
Citations
1
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: March 17, 2025
Abstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged a research hotspot, unveiling complex bidirectional communication between and brain. Studies indicate that brain can influence each other’s homeostasis via multiple pathways, yet there is dearth systematic reviews in this area. This review comprehensively examines interactions across three key areas: bone-derived factors on function, effects brain-related diseases or injuries (BRDI) health, concept skeletal interoception. Additionally, discusses innovative approaches biomaterial design inspired by mechanisms, aiming to facilitate through materiobiological aid treatment neurodegenerative bone-related diseases. Notably, integration artificial intelligence (AI) highlighted, showcasing AI’s role expediting formulation effective targeted strategies. In conclusion, offers vital insights into mechanisms suggests advanced harness these clinical practice. These offer promising avenues for preventing treating impacting skeleton brain, underscoring potential interdisciplinary enhancing human health.
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Obesity-induced bone loss affects the life quality of patients all over world. Irisin, one myokines, plays an essential role in and fat metabolism. Investigate effects irisin on metabolism via adipocytes marrow microenvironment. In this study, we fed fibronectin type III domain-containing protein 5 (FNDC5, precursor irisin) knockout mice (FNDC5-/-) with a high-fat diet (HFD) for 10 weeks. The mass was assessed by micro-CT analysis, histological staining, dynamic formation. vitro, lipogenic differentiation mesenchymal stem cells (BMSCs) assayed Oil Red O osteogenic alkaline phosphatase staining. Meanwhile, gene expression BMSC-differentiated RNA sequence involved pathway were determined western blot qRT-PCR performed. FNDC5-/- HFD showed increased body weight, content bone, decreased formation compared those standard (SD). inhibited BMSCs into alleviated inhibition osteogenesis derived from adipocyte supernatant. blocking experiment that reduced production interleukin 6 (IL-6) through downregulating TLR4/MyD88/NF-κB pathway. Immunofluorescence staining further confirmed IL-6 SD, which suffered serious loss. Irisin downregulates activation pathway, thereby reducing to enhance BMSCs. Thus, rescue BMSCs, initially IL-6, is potential therapeutic target mitigate obesity-induced osteoporosis.
Language: Английский
Citations
7
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 25, 2024
Osteoporotic fractures are characterized by abnormal inflammation, deterioration of the bone microenvironment, weakened mechanical properties, and difficulties in osteogenic differentiation. The chronic inflammatory state aging macrophages leads to delayed or non-healing fracture even formation defects. current bottleneck clinical treatment is achieve strong fixation comminuted fragments effective regulation complex microenvironment macrophages. Inspired cement gravel concrete infrastructure, a biomimetic glue with poly(lactic-co-glycolic acid) microspheres developed levodopa/oxidized chitosan hydrogel stabilized on an organic-inorganic framework nanohydroxyapatite, named DOPM. DOPM via morphological characterization techniques, vitro experiments marrow mesenchymal stromal cells, vivo aged SD rat model exhibiting osteoporotic exhibited excellent adhesion good biocompatibility, significant Transcriptomic analysis revealed that improved inhibiting NF-κB signaling pathway promoting macrophage polarization toward M2 macrophages, thus significantly accelerating defect repair regeneration. This glue, which enhances osteointegration reestablishes homeostasis has potential applications
Language: Английский
Citations
7
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 30, 2024
Natural polyphenols may have a role in counteracting oxidative stress, which is associated with aging and several bone-related diseases. Chlorogenic acid (CGA) naturally occurring polyphenolic compound formed by the esterification of caffeic quininic acids osteogenic, antioxidant, anti-inflammatory properties. This review discusses potential CGA to enhance osteogenesis increasing osteogenic capacity mesenchymal stem cells (MSCs), osteoblast survival, proliferation, differentiation, mineralization, as well its ability attenuate osteoclastogenesis enhancing osteoclast apoptosis impeding regeneration. can be involved bone remodeling acting directly on pro-osteoclasts/osteoblasts or indirectly osteoclasts activating nuclear factor kB (RANK)/RANK ligand (RANKL)/acting osteoprotegerin (OPG) system. Finally, we provide perspectives for using treat
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7411 - 7411
Published: July 5, 2024
Advancing age is associated with several age-related diseases (ARDs), musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic contributing towards considerable number patients, a deeper understanding bone aging the need hour. One underlying factors cellular senescence and its secretory phenotype (SASP). SASP comprises pro-inflammatory markers, cytokines chemokines that arrest cell growth development. The accumulation over years leads to chronic low-grade inflammation advancing age, also known as inflammaging. pathways molecular mechanisms focused on inflammaging are currently limited but increasingly being explored. Most genes, involved in coincide those cancer other ARDs like osteoarthritis (OA). Thus, exploring these using techniques sequencing, identifying combatting them most suitable approach crucial for healthy early detection ARDs. Several approaches can be used aid regeneration reduce bone. These may pharmacological, non-pharmacological lifestyle interventions. increasing evidence intricate relationship between aging, senescence, ARDs, anti-aging strategies marrow (BM).
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116571 - 116571
Published: April 26, 2024
Diabetes can lead to a disorder of bone-fat balance, significant cause osteoporosis due changes in environmental factors. Baicalin (Bai), an active ingredient Scutellaria baicalensis, has been confirmed possess antioxidant, hypoglycemic, and anti-osteoporotic effects. However, comprehensive understanding Bai's influence on diabetic (DOP), including its effects underlying mechanisms, remains elusive. This study investigated impact the equilibrium rats with DOP. The results indicated that Bai alleviated bone damage DOP by promoting osteogenesis inhibiting adipogenesis. Concurrently, through bioinformatics analysis, it was suggested mechanism action might involve P38-MAPK pathway. In vitro, found enhance development marrow mesenchymal stem cells (BMSCs) towards osteogenic lineages while suppressing their differentiation adipogenic lineages. It discovered promotion BMSC depends Additionally, synergistic effect mediated inhibitor suppressed differentiation. Our research indicates pathway play role osteogenic-adipogenic BMSCs, showcasing potential for treatment. highlights ability regulate between fat, presenting novel approach adressing
Language: Английский
Citations
5