Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 12, 2021

Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear factor kappa B (NF-kB), Janus kinase/signal transducers activators transcription (JAK-STAT), toll-like receptor (TLR) cGAS/STING, mitogen-activated protein kinase (MAPK); factors, including cytokines (e.g., interleukin (IL), interferon (IFN), necrosis (TNF)-α), chemokines C-C motif chemokine ligands (CCLs) C-X-C (CXCLs)), growth factors vascular endothelial (VEGF), transforming (TGF)-β), inflammasome; well metabolites prostaglandins, leukotrienes, thromboxane, specialized proresolving mediators (SPM), have been identified pivotal regulators initiation resolution inflammation. Nowadays, local irradiation, recombinant cytokines, neutralizing antibodies, small-molecule inhibitors, DC vaccines, oncolytic viruses, TLR agonists, SPM developed specifically modulate in cancer therapy, with some these already undergoing clinical trials. Herein, we discuss crosstalk between processes. We also highlight potential targets for harnessing cancer.

Language: Английский

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Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Sept. 21, 2020

Abstract NF-κB pathway consists of canonical and non-canonical pathways. The is activated by various stimuli, transducing a quick but transient transcriptional activity, to regulate the expression proinflammatory genes also serve as critical mediator for inflammatory response. Meanwhile, activation occurs through handful TNF receptor superfamily members. Since this involves protein synthesis, kinetics slow persistent, in concordance with its biological functions development immune cell lymphoid organ, homeostasis tightly controlled, highlighting vital roles ubiquitination these Emerging studies indicate that dysregulated activity causes inflammation-related diseases well cancers, has been long proposed potential target therapy diseases. This review attempts summarize our current knowledge updates on mechanisms regulation therapeutic application inhibition signaling cancer

Language: Английский

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Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks

Korean Journal of Family Medicine, Journal Year: 2020, Volume and Issue: 41(6), P. 365 - 373

Published: Nov. 20, 2020

One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, health risks posed by sedentary behaviors are not well known. The mean daily duration behavior is 8.3 hours among Korean 7.7 American adult population. Sedentary lifestyles spreading worldwide because a lack available spaces for exercise, increased occupational such as office work, penetration television video devices. Consequently, associated problems on rise. A lifestyle human body through various mechanisms. reduce lipoprotein lipase activity, muscle glucose, protein transporter impair lipid metabolism, diminish carbohydrate metabolism. Furthermore, it decreases cardiac output systemic blood flow while activating sympathetic nervous system, ultimately reducing insulin sensitivity vascular function. It also alters insulin-like growth factor axis circulation levels sex hormones, elevates incidence hormone-related cancers. Increased time impairs gravitostat, body's weight homeostat, gain, adiposity, elevated chronic inflammation caused risk factors cancer. have wide-ranging adverse impacts including all-cause mortality, cardiovascular disease cancer risk, metabolic disorders diabetes mellitus, hypertension, dyslipidemia; musculoskeletal arthralgia osteoporosis; depression; and, cognitive impairment. Therefore, increasing activity both important to promote public

Language: Английский

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Incidence of Programmed Cell Death 1 Inhibitor–Related Pneumonitis in Patients With Advanced Cancer

JAMA Oncology, Journal Year: 2016, Volume and Issue: 2(12), P. 1607 - 1607

Published: Aug. 19, 2016

Programmed cell death 1 (PD-1) inhibitor-related pneumonitis is a rare but clinically serious and potentially life-threatening adverse event. Little known about its incidence across different tumor types treatment regimens.To compare the of PD-1 among therapeutic regimens.A PubMed search through November 10, 2015, review references from relevant articles. For search, following keywords or corresponding Medical Subject Heading terms were used: nivolumab, pembrolizumab, inhibitor.Twenty-six original articles inhibitor trial results identified. Among them, 20 studies melanoma, non-small lung cancer (NSCLC), renal carcinoma (RCC) eligible for meta-analysis.The data extracted by primary reviewer then independently reviewed 2 secondary reviewers Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines. Comparisons based on marginal, exact generalized linear models with estimating equations.Incidence all-grade grade 3 higher pneumonitis-related deaths.Twenty single-tumor-type trials (12 melanoma studies, 5 NSCLC RCC studies) (a total 4496 unique patients) included in meta-analysis. The overall during monotherapy was 2.7% (95% CI, 1.9%-3.6%) 0.8% 0.4%-1.2%) pneumonitis. (4.1% vs 1.6%; P = .002) (1.8% 0.2%; < .001) compared melanoma. than not Four deaths observed patients group. Pneumonitis more frequent combination therapy (6.6% (1.5% therapy. Multivariable analyses demonstrated odds (odds ratio [OR], 1.43; 95% 1.08-1.89; .005) (OR, 2.85; 1.60-5.08; 1.59; 1.32-1.92; had significantly 2.04; 1.69-2.50; 2.86; 1.79- 4.35; .001).The These findings contribute to enhance awareness clinicians support further investigations meet clinical needs.

Language: Английский

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Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 11, 2021

Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases animals and man. The gut epithelium efficient barrier that prevents absorption liposaccharide (LPS). Structural changes to intestinal response dietary alterations allow LPS enter bloodstream, resulting increase plasma levels (termed endotoxemia). activates Toll-like receptor-4 (TLR4) leading production numerous pro-inflammatory cytokines and, hence, low-grade systemic inflammation. Thus, can lead several inflammatory conditions. Obesity, diabetes, non-alcoholic fatty liver disease (NAFLD) also cause permeability potential pharmacological interventions could be used reduce inflammation associated with endotoxemia.

Language: Английский

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Epidemiology of Glioblastoma Multiforme–Literature Review

Cancers, Journal Year: 2022, Volume and Issue: 14(10), P. 2412 - 2412

Published: May 13, 2022

Glioblastoma multiforme (GBM) is one of the most aggressive malignancies, with a median overall survival approximately 15 months. In this review, we analyze pathogenesis GBM, as well epidemiological data, by age, gender, and tumor location. The data indicate that GBM higher-grade primary brain significantly more common in men. risk being diagnosed glioma increases remains low, despite medical advances. addition, it difficult to determine clearly how influenced stimulants, certain medications (e.g., NSAIDs), cell phone use, exposure heavy metals.

Language: Английский

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NF‐κB signaling in inflammation and cancer

MedComm, Journal Year: 2021, Volume and Issue: 2(4), P. 618 - 653

Published: Dec. 1, 2021

Abstract Since nuclear factor of κ‐light chain enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism NF‐κB for 35 years, which lead significant progress. Meanwhile, molecular mechanisms activation also illuminated, cascades signaling events leading activity key components pathway are identified. It has suggested plays an important role human diseases, especially inflammation‐related diseases. These studies make attractive target disease treatment. This review aims summarize knowledge family members NF‐κB, as well basic activation. We will effects dysregulated on inflammation, tumorigenesis, tumor microenvironment. The progression translational study drug development targeting inflammatory diseases cancer treatment potential obstacles be discussed. Further investigations precise functions physiological pathological settings underlying urgent need develop drugs treatment, with minimal side effects.

Language: Английский

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Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Nutrients, Journal Year: 2019, Volume and Issue: 11(8), P. 1873 - 1873

Published: Aug. 12, 2019

There are over 1,000,000 publications on diet and health 480,000 references inflammation in the National Library of Medicine database. In addition, there have now been 30,000 peer-reviewed articles published relationship between diet, inflammation, outcomes. Based this voluminous literature, it is recognized that low-grade, chronic systemic associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory musculoskeletal disorders, as well impaired neurodevelopment adverse mental Dietary components modulate inflammatory status. recent years, Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize potential habitual diet. Subsequently, large rapidly growing body research investigating associations potential, determined by DII, risk wide range NCDs has emerged. narrative review, we examine current state science regarding relationships DII cancer, cardiometabolic, diseases, neurodevelopment, We synthesize findings from studies, discuss underlying mechanisms, look future novel applications adult children's (C-DII) scores new avenues investigation field nutritional research.

Language: Английский

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Inflammation, Cancer and Immunity—Implication of TRPV1 Channel

Frontiers in Oncology, Journal Year: 2019, Volume and Issue: 9

Published: Oct. 16, 2019

Process of inflammation and complex interactions between immune cancer cells within tumor microenvironment are known to drive shape the outcome neoplastic disease. Recent studies increasingly show that ion channels can be used as potential targets modulate response treat inflammatory disorders cancer. The action both innate adaptive is tightly regulated by ionic signals provided a network distinct channels. TRPV1 channel, capsaicin receptor, was recently documented expressed on system but also aberrantly in several types. It activated heat, protons, proinflammatory cytokines associated with pain inflammation. channel not only involved calcium signaling fundamental for many cellular processes takes part cell-environment crosstalk influencing cell behavior. Furthermore, studies, activation anti-cancer effects. Therefore, provides link process inflammation, immunity offers new treatment possibilities. Nevertheless, cases, results regarding contradictory need further refinement. In this review we present summary data related role immunity, limitations directions future research.

Language: Английский

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Interplay between inflammation and cancer

Advances in protein chemistry and structural biology, Journal Year: 2019, Volume and Issue: unknown, P. 199 - 245

Published: Nov. 26, 2019

Language: Английский

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