Gut–Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome DOI Creative Commons
Salvatore Pezzino, Maria Sofia,

Gloria Faletra

et al.

Biology, Journal Year: 2022, Volume and Issue: 11(11), P. 1622 - 1622

Published: Nov. 6, 2022

Non-alcoholic fatty liver disease (NAFLD) is a prevalent, multifactorial, and poorly understood with an increasing incidence worldwide. NAFLD typically asymptomatic coupled other symptoms of metabolic syndrome. The prevalence rising in tandem the obesity. In Western hemisphere, one most prevalent causes transplantation. Recent research suggests that gut microbiome dysbiosis may play significant role pathogenesis by dysregulating gut–liver axis. so-called “gut–liver axis” refers to communication feedback loop between digestive system liver. Several pathological mechanisms characterized alteration axis, such as impairment barrier increase intestinal permeability which result endotoxemia inflammation, changes bile acid profiles metabolite levels produced microbiome. This review will explore axis disruption, mediated dysbiosis, on development.

Language: Английский

Enhancing Mental Health, Well-Being and Active Lifestyles of University Students by Means of Physical Activity and Exercise Research Programs DOI Creative Commons
Cornelia Herbert

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: April 25, 2022

Mental disorders (e.g., depression) and sedentary behavior are increasing, also among emerging adults. One particular target group of adults with high sitting times vulnerability to mental university students. In particular, anxiety depressive symptoms as well stress very common The present manuscript discusses whether physical activity exercise interventions can help promote the health such will summarize current scientific evidence based on this evidence, introduce an university-based research project that investigates if activity, acute bouts low- moderate intensity buffer perceived stress, alleviate strengthen well-being (psychologically physiologically) students by positively influencing symptoms, emotion perception, body awareness subjective including overall quality life. project, its concept, multimethod approach, first results from available studies discussed in relation care needs future developments. conducted within so far briefly summarized suggest related, important further comprising aerobic exercises may work best improve (alleviate stress) after a few weeks intervention. addition, certain types (yoga particular) seem be particularly effective changing perception bodily signals, cardiac processing immediately exercise. underscore importance systematic investigations combined examination psychological physiological factors active lifestyle

Language: Английский

Citations

111

Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment DOI Creative Commons
Anastasia V. Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 22, 2022

Atherosclerosis is a predecessor of numerous cardiovascular diseases (CVD), which often lead to morbidity and mortality. Despite the knowledge pathogenesis atherosclerosis, an essential gap in our understanding exact trigger mechanism. A wide range risk factors have been discovered; however, majority them are too general clarify launching mechanism atherogenesis. Some permanent (age, gender, genetic heritage) others can be modified [tobacco smoking, physical inactivity, poor nutrition, high blood pressure, type 2 diabetes (T2D), dyslipidemia, obesity]. All taken into account. In scope this review, attention focused on hypertension, considered most widespread among all modifiable for atherosclerosis development. Moreover, pressure investigated factor. The purpose review summarize data hypertension as factor development assessment.

Language: Английский

Citations

95

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder DOI Creative Commons

Ameer Luqman,

Adil Hassan,

Mehtab Ullah

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 26, 2024

The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such essential for sustaining host equilibrium, its impact on human health can be altered by variety factors such as external variables, social behavior, age, nutrition, genetics. Gut microbes’ imbalances are related to chronic diseases including cancer, obesity, digestive disorders. Globally, recent findings show that intestinal have significant role in the formation cardiovascular disease (CVD), which still primary cause fatalities. Atherosclerosis, hypertension, diabetes, inflammation, some inherited variables all risk variables. However, studies found correlations between metabolism, flora, dietary intake. Variations diversity changes their activity thought influence CVD etiology. Furthermore, microbiota acts an endocrine organ, producing bioactive metabolites TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), bile acids, substantial wellness multiple mechanisms. purpose this overview compile current evidence highlighting intricate links microbiota, metabolites, development CVD. It focuses how dysbiosis promotes heart failure, atherosclerosis. This review explores normal physiology potential techniques targeting bacteria treatment using various microbial metabolites. also examines significance treatment, supplements, prebiotics, probiotics, antibiotic therapies, fecal transplantation, innovative approach management As result, metabolic pathways become increasingly attractive targets intervention.

Language: Английский

Citations

42

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics DOI Open Access
Mónika Fekete,

Andrea Lehoczki,

Dávid Major

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789

Published: March 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Language: Английский

Citations

23

The global burden of disease attributable to high body mass index in 204 countries and territories: Findings from 1990 to 2019 and predictions to 2035 DOI
Yuhan Chen, Li Ma, Zhigang Han

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(9), P. 3998 - 4010

Published: July 3, 2024

Abstract Aim Our study aims to provide an updated estimate of age‐ and sex‐specific deaths disability‐adjusted life years (DALYs) associated with high body mass index (BMI) from 1990 2019 at the global, regional national levels, forecast global burden disease attributed BMI 2020 2035. Methods We used data for number deaths, DALYs, age‐standardized rate (per 100 000 population), percentage change population attributable fraction Global Burden Disease Study (GBD 2019) examine BMI. further applied autoregressive integrated moving average (ARIMA) model predict period 2020‐2035. Results From 2019, DALYs increased by 148% 155.86% men, 111.67% 121.78% women, respectively. In directly accounted 8.52% [95% uncertainty intervals (UI) 0.05, 0.12] all‐cause 5.89% (95% UI 0.04, 0.08) DALYs. The highest death rates were observed in men aged 65‐69 women 75‐79. DALY age group 60‐64 both sexes. Central Asia region [163.15 107.72, 223.58) per people] Oceania [4643.33 2835.66, 6902.6) people], Fiji [319.08 213.77, 444.96) Kiribati [10 000.58 6266.55, 14159.2) had rates, BMI‐related middle‐high socio‐demographic quintile middle quintile. are projected increase sexes rise 62.79 64.31 people, while 1946 2099.54 people. Conclusions High BMIs significantly contribute burden. 2035 highlights critical need address impact obesity on public health. provides policymakers up‐to‐date comprehensive information.

Language: Английский

Citations

18

A systematic umbrella review and meta-meta-analysis of eHealth and mHealth interventions for improving lifestyle behaviours DOI Creative Commons
Ben Singh, Mavra Ahmed, Amanda E. Staiano

et al.

npj Digital Medicine, Journal Year: 2024, Volume and Issue: 7(1)

Published: July 5, 2024

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness e- and m-Health interventions designed improve physical activity, sedentary behaviour, healthy eating sleep. Nine electronic databases were searched for eligible studies published from inception 1 June 2023. Systematic reviews with meta-analyses RCTs that evaluate sleep in any adult population included. Forty-seven included, comprising 507 206,873 participants. Interventions involved mobile apps, web-based SMS interventions, 14 focused on 3 diet, 4 26 evaluating multiple behaviours. Meta-meta-analyses showed resulted improvements steps/day (mean difference, MD = 1329 [95% CI 593.9, 2065.7] steps/day), moderate-to-vigorous activity (MD 55.1 13.8, 96.4] min/week), total 44.8 21.6, 67.9] behaviour -426.3 -850.2, -2.3] fruit vegetable consumption 0.57 0.11, 1.02] servings/day), energy intake -102.9 kcals/day), saturated fat -5.5 grams/day), bodyweight -1.89 -2.42, -1.36] kg). Analyses based standardised mean differences (SMD) quality (SMD 0.56, 95% 0.40, 0.72) insomnia severity -0.90, -1.14, -0.65). Most subgroup analyses not significant, suggesting a variety are effective across diverse age health populations. These offer scalable accessible approaches help individuals adopt sustain healthier behaviours, implications broader public healthcare challenges.

Language: Английский

Citations

17

Estatística Cardiovascular – Brasil 2023 DOI Creative Commons
Gláucia Maria Moraes de Oliveira, Luísa Campos Caldeira Brant, Carísi Anne Polanczyk

et al.

Arquivos Brasileiros de Cardiologia, Journal Year: 2024, Volume and Issue: 121(2)

Published: Feb. 1, 2024

SOBRE ESTE DOCUMENTO A publicação Estatística Cardiovascular – Brasil tem por objetivo fornecer uma compilação anual dos dados e das pesquisas sobre a epidemiologia DCV no Brasil. Este documento congrega as estatísticas oficiais do Ministério da Saúde outras entidades governamentais ao lado de projeto GBD, coordenado pelo IHME Universidade Washington. Além disso, incorpora derivados várias fontes estudos científicos, inclusive coortes registros, relacionados às fatores risco [...]

Citations

16

Associations between 24-h movement behaviors and indicators of mental health and well-being across the lifespan: a systematic review DOI Creative Commons
Claire I. Groves, Christopher Huong, Carah D. Porter

et al.

Journal of Activity Sedentary and Sleep Behaviors, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 14, 2024

Abstract Researchers have adopted a variety of analytical techniques to examine the collective influence 24-h movement behaviors (i.e., physical activity, sedentary behaviors, sleep) on mental health, but efforts synthesize this growing body literature been limited studies children and youth. This systematic review investigated how combinations relate indicators ill-being well-being across lifespan. A search MEDLINE, PsycINFO, Embase, SPORTDiscus was conducted. Studies were included if they reported all three behaviors; an indicator or well-being; published in English after January 2009. Samples both clinical non-clinical populations included. total 73 ( n = 58 cross-sectional; 15 longitudinal) met our inclusion criteria, which 47 children/youth 26 adults. Seven approaches used: guideline adherence (total specific combinations), compositions, isotemporal substitution, profile/cluster analyses, Goldilocks method rest-activity rhythmicity. More associations for 127 children/youth; 53 adults) than 54 adults). Across lifespan, favorable benefits most consistently observed when components guidelines met. Movement compositions more often associated with health youth Beneficial behavior replaced sleep activity. Other analytic indicated that engaging healthier consistent patterns (emphasizing adequate sleep, maximizing minimizing behaviors) better health. Favorable less longitudinal studies. Collectively, these findings provide further support adopting integrative whole day approach promote prevent manage over status quo focusing isolation. literature, however, is still emerging—for adults particular—and work required make stronger inferences.

Language: Английский

Citations

16

Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis DOI
Veerle Knoop, B. Cloots, Axelle Costenoble

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 67, P. 101261 - 101261

Published: Feb. 6, 2021

Language: Английский

Citations

56

Early-onset colorectal cancer: Current insights and future directions DOI Open Access
Claudia Wing‐Kwan Wu, Rashid N. Lui

World Journal of Gastrointestinal Oncology, Journal Year: 2022, Volume and Issue: 14(1), P. 230 - 241

Published: Jan. 10, 2022

Early-onset colorectal cancer (EOCRC) has seen an alarming rise worldwide over the past two decades. The reason for this global trend is poorly understood. EOCRC appears to have its own unique clinical and molecular features when compared with late-onset cancer. Younger patients appear more distal or rectal disease, a advanced stage of disease at presentation, unfavorable histological features. Identifying risk factors first step in mitigating rising burden disease. Here we summarize several noteworthy biological environmental exposures that are postulated be responsible culprits. This can hopefully translate practice development better stratification tool identifying high-risk individuals early screening, areas needed further research curb trend.

Language: Английский

Citations

52